Results 91 to 100 of about 10,379 (265)

N′-[(E)-4-Chlorobenzylidene]-2-(2,3-dimethylanilino)benzohydrazide

IUCrData, 2017
In the title compound, C22H20ClN3O, the dihedral angle between the planes of the chlorophenyl and dimethylphenyl rings is 66.50 (9)°. These rings make dihedral angles 47.79 (8) and 69.24 (9)°, respectively, with the central benzene ring.
Jerry P. Jasinski, Mehmet Akkurt, Shaaban K. Mohamed, Evan M. Dunkley, Mustafa R. Albayati   +4 more
doaj   +1 more source

Heteropolyacids in synthesis of benzoyl hydrazone derivatives

Bulletin of the Chemical Society of Ethiopia, 2009
Keggin type of heteropolyacids as green reusable and efficient catalyst was used in the synthesis of benzoyl hydrazones from reaction of benzoic acid hydrazide and aldehyde and ketone derivatives.
Sodeh Sadjadi, Majid M. Heravi, Negar Mokhtari Haj, Hossein A.Oskooie, Rahim Hekmat Shoar, Fatemeh F. Bamoharram   +5 more
doaj  

COPPER CHELATION BY SYRINGIC HYDRAZONES: A PROMISING STRATEGY FOR COMBATING OXIDATIVE STRESS-RELATED DISEASES

Studia Universitatis Babes-Bolyai Chemia
Oxidative stress is a critical factor in vascular damage and the development of diseases such as atherosclerosis. This study investigates the complexation properties of two syringic hydrazones, (E)-4-Hydroxy-3,5-dimethoxybenzaldehyde -1,3-benzothiazol-2-
Nadji BELKHEIRI
doaj   +1 more source

Novel chelators based on adamantane-derived semicarbazones and hydrazones that target multiple hallmarks of Alzheimer's disease

, 2018
Alzheimer's disease (AD) is characterized by multiple pathological hallmarks, including β-amyloid aggregation, oxidative stress, and metal dys-homeostasis.
Nady Braidy, Duraippandi Palanimuthu, Patric J. Jansson, Bernhardt, Paul V, Braidy, Nady, Richardson, Des R., Palanimuthu, Duraippandi, Wu, Zhixuan, Bernhardt, Paul V., Des R. Richardson, Zhixuan Wu, Richardson, Des R, Danuta S. Kalinowski, Jansson, Patric J, Jansson, Patric J., Kalinowski, Danuta S., Kalinowski, Danuta S, Paul V. Bernhardt   +17 more
core   +1 more source

SYNTHESIS, ANTILESHMANIA AND CYTOTOXIC ACTIVITY OF HYDRAZONES FROM NATURAL ALDEHYDES

, 2020
Leishmaniasis is endemic anthropozoonosis considered to be a severe public health problem. The treatment with pentavalent antimonials presents high toxicity motivating the search for effective and less toxic drugs.
Arlan de Assis Gonsalves (4869556), Sabrina Maria Portela Carneiro (8590071), Marcília Pinheiro da Costa (8590080), Lucas Pereira Lima da Cruz (8590068), Fernando Aécio de Amorim Carvalho (8590077), Michel Muálem de Moraes Alves (8590074), Cíntia Marques Corrêa (8590083), Cleônia Roberta Melo Araújo (4869559), Valéria Carlos de Sousa (8590065), Débora Caroline Marques de Souza (6674195)   +9 more
core   +1 more source

Evaluation of DNA/Chromosome Integrity and Cell Death in Human Metabolically Noncompetent and Competent Cells Exposed to N′‐(3,5‐Difluorobenzylidene)Pyridine‐4‐Carbohydrazide

Journal of Applied Toxicology, EarlyView.
ABSTRACT The N‐acylhydrazone scaffold is recognized as a privileged structure for the design of bioactive substances with increasing applications in medicinal chemistry research. Ensuring the safety of newly developed molecules is a critical step for both human health and environmental protection. Accordingly, this study aimed to evaluate the cytotoxic
Larissa Ribeiro Canuto Santos, Jéssica Natalia Barbosa de Almeida, Camila Cavalleiro Frias, Wanda Pereira Almeida, Edson Luis Maistro   +4 more
wiley   +1 more source

New Hydrazone Derivatives Featuring Isatin and Piperazine Moieties: Synthesis, Cytotoxicity Evaluation, and Molecular Modeling Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT In this study, ten novel compounds (IPH1–IPH10) were designed by integrating three pharmacophores (isatin, piperazine, and hydrazone) commonly found in the molecular structures of anticancer agents. The target molecules were obtained by the reaction of in‐house prepared 4‐(4‐(pyridin/pyrimidin‐2‐yl)piperazin‐1‐yl)benzohydrazide with various ...
Semiha Köprü, Münevver Baran, Miyase Gözde Gündüz, Şengül Dilem Doğan   +3 more
wiley   +1 more source

Chelating agents as potential antitumorals: alfa-(N)-heterocyclic hydrazones and bis-alfa-(N)-heterocyclic hydrazones

, 1997
A number of pyruvic acid and methylpyruvate alpha-(N)-heterocyclic hydrazones has been synthesized. Bis-heterocyclic hydrazones were obtained from reaction with pyruvic carboxaldehyde.
SAVINI, LUISA, MASSARELLI, PAOLA, PELLERANO, CESARE, CHIASSERINI, LUISA, NENCINI, CRISTINA   +4 more
core  

Poly(O‐Propargyl‐N‐Amino Carbamate), a Reactive Polymer to Underpin Biomedical Applications of Poly(acetylene)s

Macromolecular Rapid Communications, EarlyView.
We report here a new methodology to prepare functional poly(acetylene)s under aqueous conditions. This methodology is underpinned by poly(O‐propargyl‐N‐amino carbamate) (P1), a reactive poly(acetylene) carrying acyl hydrazines. Thus, P1 reacts with aldehydes to give functional poly(acetylene)s, including cationic, hydrophobic, and sugar‐loaded poly ...
Tom Leigh, Greta Bellio, Daniel Crisan, Amit Deb, Alba Ramil‐Bouzas, Andrey Romanyuk, Ivan Torreiro‐Leon, Ana Rey‐Rico, Paco Fernandez‐Trillo   +8 more
wiley   +1 more source

A VERSATILE HYDRAZONES SCHIFF BASE AND METAL COMPLEXES OF PHARMACOLOGICAL APPLICATION AND BIOLOGICAL ACTIVITIES: A REVIEW

, 2017
The development of hydrazones Schiff base have been shown a wide variety of biological activities viz. antimicrobial, anticonvulsant, antidepressant, anti‑inflammatory, analgesic, antiplatelet, antimalarial, anticancer, antifungal, antitubercular ...
Gajanan Dongare
core   +1 more source