Results 111 to 120 of about 6,087 (217)
Human Pharmacokinetic Prediction of Antibody‐Drug Conjugates Using Human FcRn Transgenic Mice
Clinical and Translational Science, Volume 19, Issue 8, August 2026.ABSTRACT Antibody‐drug conjugates (ADCs) have progressed significantly in recent years, particularly in the oncology field. However, predicting human pharmacokinetics (PK) of ADCs in the early stages of drug development remains challenging. Human neonatal Fc receptor (FcRn) transgenic mice have been established as a reliable pre‐clinical PK model for ...
Keitaro Nakagawa, Kenta Haraya
wiley +1 more source
Substrate‐specific mitochondrial dysfunction and metabolomic profiles in type 2 diabetic rat hearts
Experimental Physiology, Volume 111, Issue 8, Page 3635-3647, 1 August 2026.Abstract Type 2 diabetes (T2D) greatly alters cardiac fuel handling, yet how mitochondrial function adapts to the diabetic substrate environment remains unclear. This study investigated substrate‐specific cardiac mitochondrial bioenergetics from a T2D rat model induced by a high‐fat diet and low‐dose streptozotocin.
Toan Pham
wiley +1 more source
Employing Nanotechnology to Enhance Ethanol Production in Two Synechococcus elongatus Strains
ChemBioChem, Volume 27, Issue 14, 29 July 2026.Here, we report on how bacterial microcompartment technology can be used to improve bioproduction in cyanobacteria. Fusion of encapsulation peptides to the two enzymes of the ethanol biosynthetic pathway increased ethanol titres up to 84 times. 1.31 g L−1 of ethanol was produced in 6 days.
Alexandra M. Schirmacher +3 more
wiley +1 more source
Funktionalisierung von Peptiden auf der festen Phase im späten Synthesestadium
Angewandte Chemie, Volume 138, Issue 31, 27 July 2026.Peptidmodifikationen sind für die Kontrolle der Eigenschaften von Peptidwirkstoffen von entscheidender Bedeutung. Daher sind Strategien, die einen effizienten und schnellen Einbau nicht‐kanonischer Modifikationen in Peptide in Parallelformaten ermöglichen, sehr gefragt.
Marius Werner +2 more
wiley +1 more source
Angewandte Chemie, Volume 138, Issue 31, 27 July 2026.Der peri‐benzo[a]fluoranthenthioindigo (PBFT) Photoschalter kann direkt durch Nahinfrarot‐Licht mit Wellenlängen bis zu 900 nm angeregt werden. Er bietet ein hochperformantes Eigenschaftsprofil mit kontrastreichen Farbänderungen zwischen blassgrün und tiefblau.
Elias Ciekalski, Henry Dube
wiley +1 more source
Late‐Stage Functionalization of Peptides on the Solid Phase
Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner +2 more
wiley +1 more source
A Reversible 900 nm Near‐Infrared Photoswitch for Invisibly Writable 2D and 3D Displays
Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.The peri‐benzo[a]fluoranthenethioindigo (PBFT) photoswitch enables direct excitation with near‐infrared light up to 900 nm wavelengths. It delivers a high‐performance property profile including high‐contrast color changes between bright green and deep blue.
Elias Ciekalski, Henry Dube
wiley +1 more source
The Chemical Smiler: CHEMICal Abstraction Leading to SMILEs of Reference
Journal of Computational Chemistry, Volume 47, Issue 19, 15 July 2026.Chemical notations allow computers to screen millions of substances, to retrieve experimental or regulatory information. But how to make the notations comparable by making them not only standard, but also focused on the structural details of interest? The CHEMICAL SMILER can do it.
Davide Luciani +2 more
wiley +1 more source
Novel Cinnamaldehyde Hydrazones: Design, In Silico Evaluation, Synthesis, and Cytotoxic Activity. [PDF]
MoleculesNikolova-Mladenova B +2 more
europepmc +1 more source
ChemMedChem, Volume 21, Issue 13, 14 July 2026.Hybrid diazo‐ and pyrazole‐carboxamide benzenesulfonamides emerge as highly potent and selective inhibitors of tumor‐associated carbonic anhydrases. A 3,4‐dichloro‐substituted derivative achieves sub‐2 nM inhibition of hCA IX and displays promising anticancer activity, revealing a valuable scaffold for the development of next‐generation cancer‐targeted
Suleyman Akocak +8 more
wiley +1 more source