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Furagin Derivatives—Nitrofuran‐Based Hydrazones as Potential Dual Inhibitors of Thioredoxin Reductase and Carbonic Anhydrases

open access: yesChemMedChem, Volume 21, Issue 13, 14 July 2026.
Nitrofuran‐based hydrazones derived from furagin are developed as dual inhibitors of thioredoxin reductase 1 and cancer‐associated carbonic anhydrases IX and XII. The series shows selective enzyme inhibition with reduced off‐target carbonic anhydrase (CA) I/II activity, while lead compound 7g exhibits potent TrxR1 inhibition and moderate anticancer ...
Aleksandrs Pustenko   +6 more
wiley   +1 more source

Catalytic Methods for the Transfer of Nonstabilized Carbenes. [PDF]

open access: yesACS Catal
Arnold ES   +2 more
europepmc   +1 more source

Impact of Structural Features on the Antioxidant Activity of Organofluorine Diaryl Hydrazones. [PDF]

open access: yesMolecules
Zsengellér ZK   +10 more
europepmc   +1 more source

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