Results 141 to 150 of about 6,255 (195)

Cancer Vaccine Development: Toward Artificial Intelligence‐Assisted Personalized Cell Membrane Nanovaccine

Small, Volume 22, Issue 49, 1 September 2026.
Cancer nanovaccines have emerged as promising alternatives to conventional cancer vaccines, which have shown limited clinical efficacy. In particular, cell membrane nanoparticle‐based nanovaccines can offer high biocompatibility and immunogenicity while preserving tumor antigens, including antigen repertoires.
Munsik Kim, Ilkoo Noh
wiley   +1 more source

Synthesis, cholinesterase/MAO-A inhibition, antioxidant potential and detailed computational analysis of 3,5-difluorobenzenesulfonate-tagged ethoxyvanillin hydrazones. [PDF]

RSC Adv
Fatima A, Noreen F, Şenol H, Taslimi P, Ismail MA, Alharthy RD, Rasool A, Zaki MEA, Gomha SM, Shafiq Z.   +9 more
europepmc   +1 more source

Volatile Organic Compounds in Rainwater: A New Frontier in Atmosphere–Biosphere Interactions

Journal of Geophysical Research: Biogeosciences, Volume 131, Issue 9, September 2026.
Abstract Rainwater is a key vector of atmospheric deposition, linking the atmosphere with terrestrial and aquatic ecosystems. While the inorganic chemistry of precipitation (dominated by sulfate, nitrate, ammonium, and trace metals) has been extensively studied, organic compounds in rainwater have received less attention, and Volatile Organic Compounds
Ana M. Yáñez‐Serrano, Teresa Moreno, Maria Izquierdo, Jorge Pey, Roger Seco, Andrés Alastuey, Josep Peñuelas   +6 more
wiley   +1 more source

Impact of Structural Features on the Antioxidant Activity of Organofluorine Diaryl Hydrazones. [PDF]

Molecules
Zsengellér ZK, Mastyugin M, Fusco AR, Vlocskó BR, Ferguson C, Pintye D, Nasim H, Salahuddin S, Young BC, Török B, Török M.   +10 more
europepmc   +1 more source

KAT6A–inhibitor co‐crystal structures: tackling a challenging crystallization target via two alternative approaches

Acta Crystallographica Section D, Volume 82, Issue 9, Page 1111-1124, September 2026.
We report a novel cysteine‐to‐serine surface‐mutation approach to determine co‐crystal structures of KAT6A with small‐molecule inhibitors and compare it with the previously published MYSTcryst approach which uses mutated KAT8 as a surrogate for KAT6A.
Vera Puetter, Léa Bouché, Katrin Nowak-Reppel, Steven J. Ferrara, Stefan N. Gradl, Daniel Korr, Craig A. Strathdee, Antonius ter Laak, Roman C. Hillig   +8 more
wiley   +1 more source

Chemoenzymatic Triazolopyridine Synthesis Enabled by Cryptic Diazo Formation by Vanadium-Dependent Haloperoxidases. [PDF]

Org Lett
Sharma M, Biegasiewicz KF.
europepmc   +1 more source

Apigenin Alleviates Pyroptosis in Lung Adenocarcinoma Cells by Modulating TNF‐α/NF‐κB Signaling and AIM2 Inflammasome Activation

Thoracic Cancer, Volume 17, Issue 17, September 2026.
Apigenin attenuated CCCP/FeSO4‐induced injury and pyroptosis‐associated molecular changes in A549 cells by suppressing TNF‐α/NF‐κB signaling and reducing AIM2/ASC‐associated protein expression. Integrated network pharmacology, molecular docking, molecular dynamics simulations, and LUAD transcriptomic analyses further prioritized TNF and AIM2 as ...
Kairui Zhu, Yulong Mu, Zhenguo Su, Zhen Yue, Dongyang Wu, Guiwu Qu, Chenyang Jiang, Qing Li, Youjie Li, Ning Xie   +9 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of N-Acyl-Hydrazone-Linked Quinazolinone Derivatives with Antioxidant, Antimicrobial, and Anticancer Potential. [PDF]

Pharmaceuticals (Basel)
Coandă M, Drăghici C, Pintilie L, Kapronczai EE, Chiriță C, Marinaș IC, Ancuceanu RV, Zarafu I, Ioniță P, Crăciun DI, Hudiță A, Gălățeanu B, Limban C, Nuță DC.   +13 more
europepmc   +1 more source

Investigation of the In Vitro and In Silico Anticancer Potential of Novel 4‐Arylthiazole‐Hydrazone Derivatives

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
The synthesized compounds exhibited excellent cytotoxicity on MCF‐7, breast cancer cell line with selective profile especially 2d with IC50 value of 0.12 μM. Three compounds 2c, 2d, and 2h caused almost as much apoptosis induction as cisplatin. Compound 2d exhibited caspase‐3 activation at standard drug level.
Zeynep Zişan Demirci, Erol Akgün, Gülşen Akalın Çiftçi, Leyla Yurttaş   +3 more
wiley   +1 more source

Design, synthesis, and quantitative structure-activity modeling of indole-3-pyrimidine hydrazone derivatives as novel antifungal agents. [PDF]

Pest Manag Sci
Zhang H, Wu Y, Guo T, Xiao L, Chen C, Lei Y, Fan L, Zhao X, Shi L, Peng J.   +9 more
europepmc   +1 more source