Results 151 to 160 of about 6,255 (195)

Design, Synthesis, and Biological Evaluation of Anthracene Derivatives as Potent Antioxidants: Experimental, DFT, and Docking Studies

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
A series of anthracene‐based derivatives exhibited exceptional antioxidant activity, with IC50 values surpassing ascorbic acid. DFT and molecular docking studies revealed efficient charge transfer and strong Keap1/Nrf2 binding, highlighting their potential as promising therapeutic agents against oxidative stress.
Mohamed R. Elmorsy, Menna Moustafa, Hassan A. Etman, Nashwa M. El‐Metwaly, Safa A. Badawy   +4 more
wiley   +1 more source

Dynamic Covalent Functionalization of DNA Origami via Iminoboronate Chemistry. [PDF]

J Am Chem Soc
Postigo A, Guerreiro E, Ruiz J, Navarrete-Burgos MS, Verstraeten W, Göpfrich K, Hernández-Ainsa S, Del Barrio J.   +7 more
europepmc   +1 more source

Design, Synthesis, Antimycobacterial Evaluation, and In Silico Investigation of Benzisothiazole‐Based Hydrazide Derivatives as Potential Anti‐Tuberculosis Agents

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
A novel series of benzisothiazole‐based hydrazide derivatives was designed, synthesized, and evaluated for antitubercular activity. Compound 8k emerged as the most potent candidate (MIC = 0.25 μg/mL) with a high selectivity index (SI = 42) and bactericidal activity. Molecular docking and 100 ns simulations identified InhA as the probable target.
Vivek Sharma, Arun Sharma, Ruchi Poria, Pardeep Kumar   +3 more
wiley   +1 more source

Chemoenzymatic Diazo Synthesis Enabled by Enzymatic Halide Recycling with Vanadium-Dependent Haloperoxidases. [PDF]

J Am Chem Soc
Sharma M, Li Y, McWhorter KL, Alvarez TV, Layug L, Khambatti A, Davis KM, Biegasiewicz KF.   +7 more
europepmc   +1 more source

From Fragments to Function: Novel Hydrazone Derivatives as Monoamine Oxidase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Twelve N‐acylhydrazone derivatives (5a–f, 6a–f) were synthesized and characterized. Compounds displayed potent submicromolar inhibition against both MAO‐A and MAO‐B. Compound 6e exhibited the strongest activity (IC50 = 0.073 μM for MAO‐A; 0.064 μM for MAO‐B). Kinetic and docking analyses confirmed reversible, competitive inhibition via FAD interaction.
Hasan Erdinç Sellitepe, Ahmet Buğra Aksel, Ezgi Pehlivanlar Yavrucu, Hilal Zıvalı, Begüm Nurpelin Sağlık Özkan, İnci Selin Doğan   +5 more
wiley   +1 more source

Unlocking the Potential of Isatin Scaffolds in Acetylcholinesterase Inhibition. [PDF]

Arch Pharm (Weinheim)
Tharwat T, El-Nassan HB, Adly ME, Kamel MM.   +3 more
europepmc   +1 more source

Medicinal and Crop Protection Chemistry: Breaking Barriers, Building Synergies

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
A unified view of medicinal and crop protection chemistry reveals shared scientific progress, common challenges, and new opportunities for cross‐disciplinary collaboration. Bridging expertise across both fields could accelerate innovation and actively encourage more sustainable solutions.
Giulia Cazzaniga, Giusy L. Fratello, Alexander T. Apostle, Roberto Orru, David M. Barber, Silvia Gazzola   +5 more
wiley   +1 more source

Novel Nitroxide-Substituted Hydrazone Switch: Experimental and Theoretical Insights into Photoswitching Behavior. [PDF]

ACS Org Inorg Au
Kotásková L, Nemec I, Herchel R, Santana VT, Neugebauer P.   +4 more
europepmc   +1 more source

Visible-light induced trifluoromethylation/cyclization cascade to access CF₃-containing pyrazolones by EDA complex. [PDF]

RSC Adv
Liu Z, Hu M, Gao S, Wei P, Zhao M, Sun Y, Zhang ZH.   +6 more
europepmc   +1 more source

Structural Modifications of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): New Horizons in Antimicrobial Drug Discovery. [PDF]

Arch Pharm (Weinheim)
Koçak Aslan E, Karagüzel A, Gündüz MG.   +2 more
europepmc   +1 more source