Results 131 to 140 of about 6,255 (195)

eCyclopropanation - a safe and scalable electrochemical route to cyclopropanes. [PDF]

Chem Sci
Walsh JM, Galzignato M, Hattori S, Triacca M, Lam K.   +4 more
europepmc   +1 more source

Flow Synthesis of Muscone‐Macrocycles Using the Eschenmoser Rearrangement as a Key Step

Helvetica Chimica Acta, Volume 109, Issue 9, September 2026.
A two‐step flow process, comprising the formation of hydrazones followed by Eschenmoser fragmentation, enables the efficient synthesis of macrocyclic ketones, which serve as precursors for exaltone and muscone. ABSTRACT Hydrazone formation followed by Eschenmoser fragmentation are key steps in the synthesis of muscone‐type macrocycles.
Merlin Hauer, Oliver Fifield, Florian Fricke, Alexandra Seeman, Ian R. Baxendale, Johannes Panten, Andreas Kirschning   +6 more
wiley   +1 more source

A general aqueous synthetic strategy towards 1-benzylTHIQs enabled by umpolung hydrazone. [PDF]

Chem Sci
Kaur M, Chen EFW, Salgado JM, Cheng R, Li CJ.   +4 more
europepmc   +1 more source

Fisetin Attenuates Amyloid‐Beta‐Induced Neurotoxicity in Human Neuroblastoma SH‐SY5Y Cells: Integrating In Silico Target Prediction and In Vitro Validation

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
The in‐silico data showed that fisetin binds stably with the autophagy receptors and synaptic density regulators. Further, in‐vitro data confirmed the restoration of Aβ1‐42 disrupted autophagy by fisetin. Fisetin restored the oxidative stress and ion channels, along with a reduction of AChE activity.
Charu Jaiswal, Ishika Singh, Abhishek Kumar Singh   +2 more
wiley   +1 more source

Synthesis and structure-activity relationships of indole-3-butyric acid-based hydrazones: predicting their antibacterial and antioxidant potential through integrated experimental, molecular docking and DFT studies. [PDF]

RSC Adv
Azam M, Mashhood T, Bano S, Ibrahim M, Nadeem S, Zulfiqar H, Al-Shaalan NH, Alharthi S, Amin MA, Khan MU.   +9 more
europepmc   +1 more source

Quinoline and Phthalimide Substituted Silicon Phthalocyanines as Multi‐Target Inhibitors of Cholinesterases and Carbonic Anhydrases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Two novel axially substituted silicon phthalocyanines were synthesized and characterized. Compound 2a exhibited significantly enhanced inhibition of AChE, BChE, hCA I and hCA II, supported by molecular docking and SAR analysis, highlighting its potential as a multifunctional enzyme inhibitor with promising biological activity.
Seda Ünlü, Zeynep Köksal, Kevser Kübra Kırboğa, Fikriye Tuncel Elmalı   +3 more
wiley   +1 more source

Biological Activity and Structure-Activity Relationship of Mono- and Bis-Derivatives of 3-(Arylamino)propanehydrazides. [PDF]

Biomolecules
Tumosienė I, Jonuškienė I, Petrašauskienė N, Kantminienė K.   +3 more
europepmc   +1 more source

Improving Proteolysis‐Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen, Jiayan Jiao, Huiling Yang, Tao He   +3 more
wiley   +1 more source

Emerging Chemical Upcycling and Repurposing Strategies for Waste Pharmaceuticals

ChemistrySelect, Volume 11, Issue 36, 22 September 2026.
What could be done with pharmaceutical waste from a circular chemistry perspective? A literature survey was conducted using the terms “recycling”, “upcycling”, “reuse”, “repurposing”, “pharmaceutical”, “expired drug”, “expired medicine”, “unused drug” and “unused medicine” in the databases Scopus, Web of Science and Periódicos CAPES to answer this ...
Letícia Ribeiro Magalhães, Lourena Mafra Veríssimo, Euzébio Guimarães Barbosa, Alessandro Kappel Jordão   +3 more
wiley   +1 more source

Antitumor and proliferative modulation by N- and O-heterocycles: a comprehensive review of cell growth regulation. [PDF]

Front Chem
Chinibayeva N, Unerbaeva Z, Shepilov D, Berganayeva G, Liu J, Pu X, Nurmahanova A, Zhaksylykova G, Sydykbayeva S, Dyusebaeva M.   +9 more
europepmc   +1 more source