Results 161 to 170 of about 10,379 (265)

The Dithiirane–Thiosulfine Equilibrium Revisited—A Computational Study of Structure, Thermodynamics and Kinetics

Journal of Physical Organic Chemistry, Volume 39, Issue 6, June 2026.
The dithiirane–thiosulfine equilibrium has been revisited by means of modern computational chemistry tools to shed light on whether stable thiosulfines might be isolated. ABSTRACT Thiosulfines as reactive S‐centered 1,3‐dipoles undergoing (3 + 2)‐cycloadditions are still of interest in the chemistry of sulfur‐rich heterocycles.
Dirk Buddensiek, Thomas Behrens
wiley   +1 more source

Synthesis, cholinesterase/MAO-A inhibition, antioxidant potential and detailed computational analysis of 3,5-difluorobenzenesulfonate-tagged ethoxyvanillin hydrazones. [PDF]

RSC Adv
Fatima A, Noreen F, Şenol H, Taslimi P, Ismail MA, Alharthy RD, Rasool A, Zaki MEA, Gomha SM, Shafiq Z.   +9 more
europepmc   +1 more source

Recent Advances in Photoelectrochemical Water Splitting Enabled by Covalent Organic Frameworks

Small Structures, Volume 7, Issue 6, June 2026.
This review highlights the potential of 2D covalent organic frameworks (COFs) as tunable and porous photoactive catalysts for solar‐driven water splitting. It discusses COF design principles and emerging photoelectrocatalytic performance, with special emphasis on film fabrication and deposition strategies critical for integrating COFs into efficient ...
Roman Guntermann, Shuo Sun, Jonathan Kampmann, Dana D. Medina   +3 more
wiley   +1 more source

Impact of Structural Features on the Antioxidant Activity of Organofluorine Diaryl Hydrazones. [PDF]

Molecules
Zsengellér ZK, Mastyugin M, Fusco AR, Vlocskó BR, Ferguson C, Pintye D, Nasim H, Salahuddin S, Young BC, Török B, Török M.   +10 more
europepmc   +1 more source

Chemoenzymatic Triazolopyridine Synthesis Enabled by Cryptic Diazo Formation by Vanadium-Dependent Haloperoxidases. [PDF]

Org Lett
Sharma M, Biegasiewicz KF.
europepmc   +1 more source

Thermally Bistable Stiff Stilbene Photoswitches and Polymer Applications

The Chemical Record, Volume 26, Issue 6, June 2026.
Thermally stable photoswitches offer new opportunities for controlling polymer structures and functions under nonequilibrium conditions. This Personal Account highlights stiff stilbene (SS) and sterically hindered stiff stilbene (HSS) photoswitches, which combine large structural changes with exceptional thermal bistability.
Keiichi Imato
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of N-Acyl-Hydrazone-Linked Quinazolinone Derivatives with Antioxidant, Antimicrobial, and Anticancer Potential. [PDF]

Pharmaceuticals (Basel)
Coandă M, Drăghici C, Pintilie L, Kapronczai EE, Chiriță C, Marinaș IC, Ancuceanu RV, Zarafu I, Ioniță P, Crăciun DI, Hudiță A, Gălățeanu B, Limban C, Nuță DC.   +13 more
europepmc   +1 more source

Senescent BMSC‐Derived Thbs1 Drives Inflammaging and Impairs Bone Regeneration by Suppressing PINK1/Parkin‐Mediated Mitophagy in Macrophages

Aging Cell, Volume 25, Issue 6, June 2026.
Aging BMSC‐derived Thbs1 activates the macrophage TGF‐β/Smad3 pathway to transcriptionally repress Pink1, impairing mitophagy and causing mitochondrial ROS accumulation. This redox imbalance drives M1 polarization and IL‐6 secretion. IL‐6 feeds back to BMSCs via the JAK/STAT3 pathway to inhibit osteogenesis and upregulate Thbs1, establishing a self ...
Yifeng Xing, Jingjing Su, Yanjun Lin, Nengwen Huang, Sihui Zhang, Yuwei Zhou, Jie Lu, Weiping Chen, Kaixun He, Wenxiu Yuan, Yang Li, Geyuan Zheng, Pengyuan Hu, Dong Wu, Yanjing Ou, Jiang Chen   +15 more
wiley   +1 more source

Visible-light induced trifluoromethylation/cyclization cascade to access CF₃-containing pyrazolones by EDA complex. [PDF]

RSC Adv
Liu Z, Hu M, Gao S, Wei P, Zhao M, Sun Y, Zhang ZH.   +6 more
europepmc   +1 more source

Cruzain Inhibitors for Chagas Disease: Anticorrelated Optimisation Landscapes and the Multiparametric Path to Clinical Candidates

Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.
Three decades of cruzain‐targeted drug discovery have yielded 215 sub‐micromolar inhibitors but no clinical candidates. This review diagnoses a systemic translational failure driven by single‐parameter optimisation and proposes a multiparametric framework integrating enzymatic potency, cathepsin selectivity, intracellular exposure, and metabolic ...
Caroline Rodrigues Chaves dos Reis, Hellen Valério Chaves Moura de Souza, Lidia Corrêa Parra, Guilber Valério Chaves Moura de Souza, Bruna Costa Zorzanelli, Nubia Boechat, Lucas Villas Bôas Hoelz, Tácio Vinício Amorim Fernandes   +7 more
wiley   +1 more source