Results 21 to 30 of about 50,011 (341)

Benzothiazolyl and Benzoxazoyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53.

Journal of Medicinal Chemistry, 2021
We identified a set of thiosemicarbazone (TSC) metal ion chelators that reactivate specific zinc-deficient p53 mutants using a mechanism called zinc metallochaperones (ZMCs) that restore zinc binding by shuttling zinc into cells.
John Gilleran, Xin Yu, Alan J Blayney, A. Bencivenga, Bing Na, D. Augeri, A. Blanden, S. D. Kimball, S. Loh, J. Y. Roberge, D. Carpizo   +10 more
semanticscholar   +1 more source

Simple oxidation of pyrimidinylhydrazones to triazolopyrimidines and their inhibition of Shiga toxin trafficking [PDF]

, 2010
The oxidative cyclisation of a range of benzothieno[2,3-d]pyrimidine hydrazones (7a–j) to the 1,2,4-triazolo[4,3-c]pyrimidines (8a–j) catalysed by lithium iodide or to the 1,2,4-triazolo[1,5-c]pyrimidines (10a–j) with sodium carbonate is presented.
Ahmed, Bhaskar, Brown, Chen, Curini, Dai, El Ashry, Feng, Gundla, Guy J. Clarkson, Han, Hassan, J. Michael Lord, Jennings, Joe, Khattab, Krueger, Kumar, Kumar, Lin, Lucie J. Guetzoyan, Lynne M. Roberts, Modena, Nagamatsu, Nagaraju, Phoujdar, Prakash, Prakash, Prakash, Prasad, Ram, Rashad, Rashad, Robert A. Spooner, Sadana, Shaban, Shaban, Sheldrick, Sheldrick, Shibahara, Shishoo, Spooner, Thakur, Tonnar, Vorob'ev, Wang, Yarrow   +46 more
core   +1 more source

ON/OFF Photostimulation of Isatin Bipyridyl Hydrazones: Photochemical and Spectral Study

Molecules, 2019
Four novel isatin hydrazones containing bipyridyl fragments were synthesized as potential ON/OFF switches. Hydrazone Z-isomers exhibit high thermal stability.
Róbert Šandrik, Pavol Tisovský, Klaudia Csicsai, Jana Donovalová, Martin Gáplovský, Róbert Sokolík, Juraj Filo, Anton Gáplovský   +7 more
doaj   +1 more source

Asymmetric synthesis of 2-substituted oxetan-3-ones via metalated SAMP/RAMP hydrazones [PDF]

, 2013
2-Substituted oxetan-3-ones can be prepared in good yields and enantioselectivities (up to 84% ee) by the metalation of the SAMP/RAMP hydrazones of oxetan-3-one, followed by reaction with a range of electrophiles that include alkyl, allyl, and benzyl ...
Beasley, Benjamin, Clarkson, Guy J., Geden, Joanna V., Shipman, Michael   +3 more
core   +1 more source

Synthesis of Novel Potent Biologically Active N-Benzylisatin-Aryl Hydrazones in Comparison with Lung Cancer Drug ‘Gefitinib’

Applied Sciences, 2020
Developing anticancer therapeutics with no/few side effects is a challenge for medicinal chemists. The absence of antibacterial activity of an anticancer drug removes its detrimental effect toward intestinal flora and therefore leads to reduced side ...
Huda S. Al-Salem, Hatem A. Abuelizz, Iman S. Issa, Amany Z. Mahmoud, Ali AlHoshani, Md Arifuzzaman, A. F. M. Motiur Rahman   +6 more
doaj   +1 more source

Copper-Catalyzed Oxidation of Hydrazones to Diazo Compounds Using Oxygen as the Terminal Oxidant

, 2021
A mild method for accessing diazo compounds via aerobic oxidation of hydrazones is described. This catalytic transformation employs a Cu(OAc)2/pyridine catalyst and molecular oxygen from ambient ai...
Wenbin Liu, Jack Twilton, Boran Wei, Maizie Lee, Melissa N. Hopkins, J. Bacsa, S. Stahl, H. Davies   +7 more
semanticscholar   +1 more source

Review on Analytical and Biological Applications of Hydrazones and their Metal Complexes

E-Journal of Chemistry, 2012
Hydrazones are very important group of analytical regents for the determination of various metal ions by using various analytical techniques. Besides this use of hydrazones are also having biological activities also.
Lakshmi Narayana Suvarapu, Young Kyo Seo, Sung-Ok Baek, Varada Reddy Ammireddy   +3 more
doaj   +1 more source

Tailoring, spectroscopic, DFT, solvatochromic, antitumor, and molecular docking studies of new polynuclear Cu(II)-hydrazone complexes. [PDF]

Sci Rep
Samy F, Shebl M, Abdelrhman EM.
europepmc   +3 more sources

Microwave assisted synthesis and antimicrobial activity of 2-quinoxalinone-3-hydrazone derivatives [PDF]

, 2010
A simple and efficient method has been developed for the synthesis of various 2-quinoxalinone-3-hydrazone derivatives using microwave irradiation technique. The series of 2-quinoxalinone-3-hydrazone derivatives synthesized, were structurally confirmed by
Ajani, Olayinka O.
core   +1 more source

Clean Grinding Technique: A Facile Synthesis and In Silico Antiviral Activity of Hydrazones, Pyrazoles, and Pyrazines Bearing Thiazole Moiety against SARS-CoV-2 Main Protease (Mpro)

Molecules, 2020
A novel series of some hydrazones bearing thiazole moiety were generated via solvent-drop grinding of thiazole carbohydrazide 2 with various carbonyl compounds.
Sraa Abu-Melha, M. M. Edrees, S. Riyadh, Mohamad R. Abdelaziz, Abdo A. Elfiky, Sobhi M. Gomha   +5 more
semanticscholar   +1 more source