Results 41 to 50 of about 18,062 (258)

Synthesis of N-phenyl- and N-thiazolyl-1H-indazoles by copper-catalyzed intramolecular N-arylation of ortho-chlorinated arylhydrazones

Beilstein Journal of Organic Chemistry, 2022
The broad application of 1H-indazoles has prompted the development of several approaches for the synthesis of such compounds, including metal-free, palladium-, or copper-promoted intramolecular N-arylation of in situ-generated or isolated o ...
Yara Cristina Marchioro Barbosa, Guilherme Caneppele Paveglio, Claudio Martin Pereira de Pereira, Sidnei Moura, Cristiane Storck Schwalm, Gleison Antonio Casagrande, Lucas Pizzuti   +6 more
doaj   +1 more source

Microwave Assisted Synthesis and Antimicrobial Potential of Quinoline- Based 4-Hydrazide-Hydrazone Derivatives [PDF]

, 2018
Quinoline is a benzo-fused pyridine which is a therapeutically important heterocycle in medicinal chemistry research and new drug development. A series of 12 new hydrazide-hydrazone motifs bearing quinoline core 4a–l was successfully synthesized by ...
Afzal, Ajani, Ajani, Almansour, Arafa, Baptiste, Bingul, Brouet, Chen, Chung, Cihan-Üstündağ, Gopinath, Gupta, Kannappan, Kharb, Kumar, Ladhani, Nair, Pandeya, Phopin, Russell, Sloop, Sonawane, Tehrani, Verma, Wang, Zhang   +26 more
core   +1 more source

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

Convergent Total Synthesis of 16β‐Hydroxylpseudobufarenogin

Angewandte Chemie, EarlyView.
We present a novel convergent strategy that integrates Pd/Ag‐promoted Suzuki–Miyaura coupling with Ir‐catalyzed radical‐relay cyclization, enabling the first total synthesis of 16β‐hydroxylpseudobufarenogin. This approach is broadly applicable to the total synthesis of various oxygenated bufadienolides by simply modifying the fragment structures ...
Wataru Shigematsu, Yo Matsumoto, Koichi Hagiwara, Masayuki Inoue   +3 more
wiley   +2 more sources

Harnessing the versatility of hydrazones through electrosynthetic oxidative transformations

Beilstein Journal of Organic Chemistry
Hydrazones are important structural motifs in organic synthesis, providing a useful molecular platform for the construction of valuable compounds. Electrooxidative transformations of hydrazones constitute an attractive opportunity to take advantage of ...
Aurélie Claraz
doaj   +1 more source

Synthesis and Biological Evaluation of Thiazolyl-Ethylidene Hydrazino-Thiazole Derivatives: A Novel Heterocyclic System

Applied Sciences, 2021
The reaction of 2-(1-(2-(2-(4-methoxybenzylidene)hydrazinyl)-4-methylthiazol-5-yl)ethylidene)hydrazinecarbothioamide with a range of hydrazonoyl chlorides and α-halo-compounds yielded three new series of thiazole derivatives.
Laila A. Al-Mutabagani, Fathy M. Abdelrazek, Sobhi M. Gomha, Ali S. Hebishy, Mohamed S. Abdelfattah, Safaa M. Hassan, Abdelwahed R. Sayed, Mahmoud M. Elaasser   +7 more
doaj   +1 more source

Isomerization Mechanism in Hydrazone-Based Rotary Switches: Lateral Shift, Rotation, or Tautomerization? [PDF]

, 2011
Two intramolecularly hydrogen-bonded arylhydrazone (aryl = phenyl or naphthyl) molecular switches have been synthesized, and their full and reversible switching between the E and Z configurations have been demonstrated.
Aprahamian, Ivan, Benítez, Diego, Elhabiri, Mourad, Goddard, William A., III, Lafranchi, Don Antoine, Landge, Shainaz M., Tkatchouk, Ekaterina   +6 more
core   +1 more source

On the discovery and development of tandem 1,4- and 1,2-addition of phosphites to 1-azadienes [PDF]

, 2014
Over the past 15 years we have developed a one-step protocol for the synthesis of 3-phosphonylated aminophosphonates from alpha,beta-unsaturated imines through tandem 1,4-1,2-phosphite addition.
Debrouwer, Wouter, Heugebaert, Thomas, Stevens, Christian, Van Waes, Frederik   +3 more
core   +2 more sources

Nanodiamond Quantum Sensors for Probing Free Radical Biology

Advanced Functional Materials, EarlyView.
Free radicals play key roles in cellular signaling and disease but remain difficult to measure in living systems. Nanodiamonds (NDs) with nitrogen‐vacancy (NV) centers enable quantum sensing of local magnetic noise via T₁ relaxometry, providing nondestructive radical detection in living cells.
Qi Lu, Yingke Wu, Tanja Weil
wiley   +1 more source

Coagulative Granular Hydrogels with an Enzyme Catalyzed Fibrin Network for Endogenous Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Coagulative granular hydrogels are composed of packed thrombin‐functionalized microgels that catalyze the conversion of fibrinogen into a secondary fibrin network, filling the interstitial voids. This bio‐inspired approach stabilizes the biomaterial to match the robustness of bulk hydrogels without compromising injectability, mimicking the initial ...
Zhipeng Deng, Camila B. Tovani, Simona Bianco, Gianni Comandini, Aya Elghajiji, Mina Aleemardani, Roxana Moscalu, Jeremie Zappia, Bianca Fernandes, Olivia Annett, Chrissy L. Hammond, Jason Wong, Dave J. Adams, Fabrizio Scarpa, Michael R. Whitehouse, Annela M. Seddon, James P. K. Armstrong   +16 more
wiley   +1 more source