Results 51 to 60 of about 18,062 (258)

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Síntese e avaliação preliminar da atividade antinociceptiva de novas isoxazolil-aril-hidrazonas

Química Nova, 2011
New 2-isoxazoline aldehydes were synthesized, in good yields, from cycloadduct of the 1,3-dipolar cycloaddition reaction between endocyclic enecarbamate and carboethoxyformonitrile oxide (CEFNO). Condensation of these 2-isoxazoline aldehydes with several
Sílvio Leandro Gonçalves Bomfim Reis, Valderes Moraes de Almeida, Gleybson Correia de Almeida, Karinna Moura Boaviagem, Charles Christophe Du Barriere Mendes, Antônio Rodolfo de Faria, Alexandre José da Silva Góes, Laudelina Rodrigues Magalhães, Teresinha Gonçalves da Silva   +8 more
doaj   +1 more source

Hydrazones of 4-(Trifluoromethyl)benzohydrazide as New Inhibitors of Acetyl- and Butyrylcholinesterase

Molecules, 2021
Based on the broad spectrum of biological activity of hydrazide–hydrazones, trifluoromethyl compounds, and clinical usage of cholinesterase inhibitors, we investigated hydrazones obtained from 4-(trifluoromethyl)benzohydrazide and various benzaldehydes ...
Martin Krátký, Katarína Svrčková, Quynh Anh Vu, Šárka Štěpánková, Jarmila Vinšová   +4 more
doaj   +1 more source

Synthesis of enantioenriched azo compounds: Organocatalytic Michael addition of formaldehyde N-tert-butyl hydrazone to nitroalkenes [PDF]

, 2013
The unprecedented diaza-ene reaction of formaldehyde N-tert-butyl hydrazone with nitroalkenes can be efficiently catalyzed by an axially chiral bis-thiourea to afford the corresponding diazenes in good to excellent yields (60-96%) and moderate ...
Bernal Fernández, Pablo, Daza Sánchez, Silvia, Fernández Fernández, Rosario Fátima, Lassaletta Simón, José María, Monge Fernández, David   +4 more
core   +1 more source

Phototunable Polarization Volume Gratings Driven by Chiral Hydrazone Switches

Advanced Optical Materials, EarlyView.
Chiral hydrazone photoswitches incorporated into polarization volume gratings enable light‐driven, reversible modulation of optical properties. UV and blue light irradiation reversibly alter the hydrazone isomer ratio, leading to tunable diffraction efficiency and spectral response across the visible spectrum.
Artem Boichuk, Lauri Uosukainen, Indu Bala, Ivan Aprahamian, Arri Priimagi   +4 more
wiley   +1 more source

Biological Activities of Hydrazone Derivatives

Molecules, 2007
There has been considerable interest in the development of novel compounds with anticonvulsant, antidepressant, analgesic, antiinflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, antitumoral, vasodilator, antiviral and ...
S. Güniz Küçükgüzel, Sevim Rollas   +1 more
doaj   +1 more source

Synthesis and Characterization of Novel Hydrazone Derivatives of Isonicotinic Hydrazide and Their Evaluation for Antibacterial and Cytotoxic Potential

Molecules, 2022
Hydrazones are active compounds having an azomethine –NHN=CH group and are widely studied owing to their ease of preparation and diverse pharmacological benefits.
Muhammad Abdullah Shah, Ala Uddin, Muhammad Raza Shah, Imdad Ali, Riaz Ullah, Peer Abdul Hannan, Hidayat Hussain   +6 more
doaj   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

In Silico Evaluation and In Vitro Determination of Neuroprotective and MAO-B Inhibitory Effects of Pyrrole-Based Hydrazones: A Therapeutic Approach to Parkinson’s Disease

Molecules, 2022
Parkinson’s disease is a huge burden in modern medicinal practice. A serious drawback of current antiparkinsonian therapy is its symptomatic nature. This directed our investigations in the search for new more potent derivatives, affecting not only the ...
Magdalena Kondeva-Burdina, Emilio Mateev, Borislav Angelov, Virginia Tzankova, Maya Georgieva   +4 more
doaj   +1 more source

Bivalent Enzyme Inhibitors Discovered Using Dynamic Covalent Chemistry [PDF]

, 2012
A bivalent dynamic covalent chemistry (DCC) system has been designed to selectively target members of the homodimeric glutathione-S-transferase (GST) enzyme family.
Ang, Appiah-Opong, Beeren, Beeren, Beeren, Bhat, Bhat, Blanden, Bunyapaiboonsri, Bunyapaiboonsri, Carroll, Cheng, Cho, Corbett, Corbett, Corbett, Cordes, Cousins, Deng, Dirksen, Dorion, Erlanson, Federici, Furlan, Gromova, Habig, Hayes, Hochgürtel, Huc, Jao, Li, Lins, Liu, Liénard, Liénard, Lyon, Maeda, Mahajan, Mannervik, McIlwain, Oakley, Oakley, Oakley, Patskovsky, Poulsen, Poulsen, Ralat, Ramström, Ramström, Roberts, Romieu, Ryoo, Sampsonas, Severin, Sheehan, Shi, Simpson, Simpson, Son, Townsend, Tsuboi, Woon, Xue, Zameo, Zameo   +64 more
core   +1 more source