Results 61 to 70 of about 6,255 (195)

Activation of Metal Complexes With Ultrasound Waves for Targeted Anticancer Therapy

Angewandte Chemie International Edition, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

An overview on synthetic aspects and biological activity profiles of hydrazone derivatives

Discover Chemistry
In the realm of medicinal chemistry, hydrazide-hydrazones represent a versatile class of compounds that have attracted significant attention due to their structural flexibility with respect to molecular design and wide-ranging biological activities ...
K. Nagaraj Pai, K. Subrahmanya Bhat
doaj   +1 more source

Design, Synthesis and Evaluation of Antiproliferative Activity of New Benzimidazolehydrazones

Molecules, 2016
The synthesis and antiproliferative activity of new benzimidazole derivatives bearing an hydrazone mojety at the 2-position is described. The new N′-(4-arylidene)-1H-benzo[d]imidazole-2-carbohydrazides were evaluated for their cytostatic activity toward ...
Valentina Onnis, Monica Demurtas, Alessandro Deplano, Gianfranco Balboni, Anna Baldisserotto, Stefano Manfredini, Salvatore Pacifico, Sandra Liekens, Jan Balzarini   +8 more
doaj   +1 more source

Design, Synthesis and Molecular Docking Studies of Some Novel Hydrazone Derivatives Based on Trimetazidine as Selective and Potent AChE Inhibitors. [PDF]

Drug Dev Res
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disease, and cholinergic dysfunction is considered one of the fundamental pathological factors of this disease. Guided by the clinically used acetylcholinesterase (AChE) inhibitor donepezil, we explored trimetazidine dihydrochloride as an accessible starting scaffold to generate ...
Doğan MO, Özkan BNS, Karaduman AB, Karakuş S, Özkay Y, Kaplancıklı ZA, Tok F.   +6 more
europepmc   +2 more sources

Dosing PPARγ Activation With Light Using Fast Relaxing Photoswitches

Angewandte Chemie International Edition, EarlyView.
To achieve spatiotemporal control over PPARγ activity, we designed the fast‐relaxing photoswitchable agonist 6 that selectively activates PPARγ in its light‐induced Z‐state and relaxes within seconds (t1/2 47 s) to the inactive E‐state. This unique profile allowed light‐dosed receptor activation in in vitro settings, enabling biological studies on ...
Loris Knümann, Alba Rodriguez‐Paniagua, Martin Reynders, Silke Duensing‐Kropp, Oliver Thorn‐Seshold, Vasily Morozov, Julian A. Marschner, Daniel Merk   +7 more
wiley   +1 more source

N′-[(E)-4-Chlorobenzylidene]-2-(2,3-dimethylanilino)benzohydrazide

IUCrData, 2017
In the title compound, C22H20ClN3O, the dihedral angle between the planes of the chlorophenyl and dimethylphenyl rings is 66.50 (9)°. These rings make dihedral angles 47.79 (8) and 69.24 (9)°, respectively, with the central benzene ring.
Jerry P. Jasinski, Mehmet Akkurt, Shaaban K. Mohamed, Evan M. Dunkley, Mustafa R. Albayati   +4 more
doaj   +1 more source

Heteropolyacids in synthesis of benzoyl hydrazone derivatives

Bulletin of the Chemical Society of Ethiopia, 2009
Keggin type of heteropolyacids as green reusable and efficient catalyst was used in the synthesis of benzoyl hydrazones from reaction of benzoic acid hydrazide and aldehyde and ketone derivatives.
Sodeh Sadjadi, Majid M. Heravi, Negar Mokhtari Haj, Hossein A.Oskooie, Rahim Hekmat Shoar, Fatemeh F. Bamoharram   +5 more
doaj  

COPPER CHELATION BY SYRINGIC HYDRAZONES: A PROMISING STRATEGY FOR COMBATING OXIDATIVE STRESS-RELATED DISEASES

Studia Universitatis Babes-Bolyai Chemia
Oxidative stress is a critical factor in vascular damage and the development of diseases such as atherosclerosis. This study investigates the complexation properties of two syringic hydrazones, (E)-4-Hydroxy-3,5-dimethoxybenzaldehyde -1,3-benzothiazol-2-
Nadji BELKHEIRI
doaj   +1 more source

Partially Biobased Polyurethanes With Reversibly Crosslinkable Furan Units Toward Recyclable Thermosetting Textile Fibres

Chemistry – A European Journal, EarlyView.
A molecular design strategy combines lignin‐derived aromatic units, sugar‐derived furan groups, and flexible glycol segments to create wet‐spinnable polyurethanes. Thermally reversible Diels–Alder crosslinking chemistry enables formation of crosslinked thermosetting fibers, repeated de‐crosslinking/re‐crosslinking cycles, and tunable fiber properties ...
Rafael N. L. Menezes, Fredrik Bäcklund, Tam T. Nguyen, Maria Maukonen, Zengwei Guo, Olga Gordivska, Cecilia Hansson, Baozhong Zhang   +7 more
wiley   +1 more source

The Radical Chemistry of 2,3‐Diguanidinopyridines: Coordination and Visible‐Light Photochemistry

Chemistry – A European Journal, EarlyView.
Substitution at the pyridine core of 2,3‐diguanidinopyridines was used to develop novel redox‐active molecules with three interconvertible redox states. They are applied as redox‐active ligands in coordination chemistry. Visible‐light irradiation of the pyridine N‐benzylated molecules leads to photoconversion to a higher‐energetic isomer.
Hanna Koepcke, Etienne Engels, Elisabeth Kaifer, Hans‐Jörg Himmel   +3 more
wiley   +1 more source