Results 31 to 40 of about 562 (194)

Synthesis of New 3-Heteroarylindoles as Potential Anticancer Agents

open access: yesMolecules, 2016
2-(3-(1H-Indol-3-yl)-5-(p-tolyl)-4,5-dihydro-1H-pyrazol-1-yl)-4-substituted-5-(substituted diazenyl)thiazoles and 2-(1H-indol-3-yl)-9-substituted-4,7-disubstituted pyrido[3,2-e][1,2,4]triazolo[4,3-a]pyrimidin-5(7H)-ones were synthesized via reaction of ...
Abdou O. Abdelhamid   +3 more
doaj   +1 more source

Hydrazonoyl Chlorides as Precursors for Synthesis of Novel Bis-Pyrrole Derivatives

open access: yesMolecules, 2016
A convenient synthesis of some novel bis-pyrrole derivatives via hydrazonoyl halides is described. Antimicrobial evaluation of some selected examples of the synthesized products was carried out.
Nabila Abdelshafy Kheder
doaj   +1 more source

Ecofriendly regioselective one-pot synthesis of chromeno[4,3-d][1,2,4]triazolo[4,3-a]pyrimidine derivatives [PDF]

open access: yes, 2013
The reaction between 2-mercapto-3H-chromeno[4,3-d]pyrimidine-4,5-dione (1) or its 2-methylthio derivative (7) with hydrazonoyl halides (2) in dioxane under ultrasound irradiation in the presence of chitosan yielded chromeno[4,3-d][1,2,4]triazolo[4,3-a ...
Badrey, Mohamed Gomaa   +1 more
core   +1 more source

Utility of 5-(furan-2-yl)-3-(p-tolyl)-4,5-dihydro-1H-pyrazole-1-carbothioamide in the synthesis of heterocyclic compounds with antimicrobial activity

open access: yesBMC Chemistry, 2019
Background Pyrazolines show different biological activities. In recent years, interest in the chemistry of hydrazonoyl halides has been renewed. 1,3,4-Thiadiazoles are one of the most common heterocyclic pharmacophores with a wide range of biological ...
Abdou O. Abdelhamid   +5 more
doaj   +1 more source

Study on regioselective synthesis of bioactive bis-spiropyrazolines using molecular orbital calculations [PDF]

open access: yes, 2014
1,3-Dipolar cycloaddition reaction of (2E,2'E)-2,2'-(1,4-phenylene bis(methanylylidene)) bis(3,4-dihydronaphthalen-1(2H)-one) (3) and 2,2'-(1,4-phenylene bis(methanylylidene)) bis(1H-indene-1,3(2H)-dione) (8) with a variety of nitrilimines, generated in ...
Abbas, Ikhlass Mohamed   +3 more
core   +1 more source

Mechanistic insights of the copper(I)-catalysed reaction between chlorohydrazones and terminal alkynes [PDF]

open access: yes, 2023
Deuterium incorporation in the 5-substituted pyrazoles arising from the copper(I)-catalysed reaction between chlorohydrazones and terminal acetylenes suggest the intermediacy of copper(I)-complexed alkynylhydrazones.
Molteni, Giorgio   +2 more
core   +1 more source

Synthesis of novel thiazole, pyranothiazole, thiazolo[4,5-b]pyridines and thiazolo[5′,4′:5,6]pyrano[2,3-d]pyrimidine derivatives and incorporating isoindoline-1,3-dione group

open access: yesBMC Chemistry, 2019
Background Thiazole is a core structural motif presents in a wide range of natural products. Thiazole derivatives also have a wide range of medicinal and biological properties. Results The reaction of hydrazonoyl halides with 2-(1-(4-(1,3-dioxoisoindolin-
Mona A. Hosny   +3 more
doaj   +1 more source

Novel thiadiazole-thiazole hybrids: synthesis, molecular docking, and cytotoxicity evaluation against liver cancer cell lines

open access: yesJournal of Taibah University for Science, 2022
One of the worst diseases, cancer claims millions of lives each year throughout the world, necessitating the creation of novel treatments. In this study, we designed a novel series of 1,3,4-thiadiazoles through the reaction of 2-(4-methyl-2-(2-(1 ...
Ghadah F. Aljohani   +6 more
doaj   +1 more source

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