Results 21 to 30 of about 21,823 (203)

USE OF FIXED COMBINATIONS OF RAMIPRIL AND HYDROCHLOROTHIAZIDE IN PATIENTS WITH ARTERIAL HYPERTENSION AND HIGH OR VERY HIGH CARDIOVASCULAR RISK (OPTIMIST 2 STUDY): RESULTS OF THE NONCOMPARATIVE STUDY

Рациональная фармакотерапия в кардиологии, 2016
Aim. To evaluate efficacy and safety of treatment with fixed combination of ramipril and hydrochlorothiazide in patients with arterial hypertension (HT) 2-3 degree and high or very high cardiovascular risk in clinical practice.
I. A. Velizhanina, L. I. Gapon, E. S. Velizhanina, A. V. Rudakov, T. S. Zhupanova   +4 more
doaj   +1 more source

Fixed Combination Lisinopril Plus Hydrochlorothiazide in the Treatment of Essential Arterial Hypertension: An Opened, Multi-Centre, Prospective Clinical Trial

Biomolecules & Biomedicine, 2007
The aim of this trial was to examine the efficacy and safety of antihypertensive fixed combination lisinopril plus hydrochlorothiazide (Lopril H, Bosnalijek dd) in the treatment of essential arterial hypertension. In our trial we included 297 patients,
Vjekoslav Gerc, Begler Begović, Midhat Vehabović, Leonid Georgievich Voronkov, Eleonora Vataman, Ljiljana Musić, Marko Bukša, Zumreta Kušljugić, Maria Grigorevna Ilyash, Larisa Michaylovna Ena, Vera Iosifovna Tchelujko, Alexander Ivanovich Dyaduk, Andrey Eduardovich Bagrij, Svetlana Alekseevna Andrievskaja, Aleksandar Lazarević, Božidarka Knežević, Faik Hima   +16 more
doaj   +1 more source

First Line CombinAtion Therapy in the Treatment of Stage II and III Hypertension (FLASH)

Frontiers in Cardiovascular Medicine, 2020
Background: Lowering blood pressure (BP) leads to reduced risk of stroke, myocardial infarction, and cardiovascular mortality. Single-pill combination therapies may deliver better BP control than increasing the dose of monotherapies or using more drugs ...
David Spirk, Sarah Noll, Michel Burnier, Stefano Rimoldi, Georg Noll, Georg Noll, Isabella Sudano, Isabella Sudano   +7 more
doaj   +1 more source

Drugs induced Raynaud's phenomenon and underlying mechanism: a disproportionality analysis from the WHO pharmacovigilance database

Arthritis &Rheumatology, Accepted Article.
Objectives The aim of this study is to generate hypotheses about unknown drugs associated with the onset or worsening of Raynaud's Phenomenon (RP) and to explore their potential pathophysiological mechanisms through a mixed disproportionality/clustering analysis from the WHO pharmacovigilance database.
Alex Hlavaty, Loubna Dari, Jean‐Luc Cracowski, Matthieu Roustit, Charles Khouri   +4 more
wiley   +1 more source

Highly sensitive determination of methyldopa and hydrochloro­thiazide using CoMoO4 nanosheets-modified screen-printed electrode

Journal of Electrochemical Science and Engineering
A novel screen-printed electrode (SPE) modified by CoMoO4 nanosheets (CoMoO4 NSs) was designed to analyse hydrochlorothiazide. Cyclic voltammetry, chronoamprometry and differential pulse voltammetry using the developed electrode were performed to ...
Shams B. Ali
doaj   +1 more source

Acute hepatocellular and cholestatic injury during therapy with hydrochlorothiazide - clinicohistopathologic findings: a case report

Journal of Medical Case Reports, 2010
Introduction Hydrochlorothiazide and thiazide-like diuretics are considered first-line drugs for initial therapy in uncomplicated arterial hypertension. Acute cholecystitis is a well-known complication during treatment with thiazide, and these drugs are ...
Grilli Elisabetta, Capone Alessandro, Pieri Stefano, Falasca Laura, Baiocchini Andrea, Del Nonno Franca, Taglietti Fabrizio, Chinello Pierangelo, Petrosillo Nicola   +8 more
doaj   +1 more source

Prescribing competence: The pros and cons of different methods for assessment

British Journal of Clinical Pharmacology, EarlyView.
Evaluating a medical graduate’s competence in rational prescribing is challenging. With the aim to guide and inspire teachers, this narrative review explores different methods that can be used to assess prescribing competence. Each method has its own advantages and disadvantages, and thus a mix of different assessment methods is needed throughout the ...
David J. Brinkman, Erik M. Donker, Jelle Tichelaar, on behalf of the CP4T programme   +3 more
wiley   +1 more source

Preparation of Hydrochlorothiazide Nanoparticles for Solubility Enhancement

Molecules, 2016
Nanoparticles can be considered as a useful tool for improving properties of poorly soluble active ingredients. Hydrochlorothiazide (Class IV of the Biopharmaceutical Classification System) was chosen as a model compound.
Eliska Vaculikova, Aneta Cernikova, Daniela Placha, Martin Pisarcik, Pavlina Peikertova, Katerina Dedkova, Ferdinand Devinsky, Josef Jampilek   +7 more
doaj   +1 more source

Trends in 25 years of antihypertensive agent utilization in Croatia – an alert for scientific community and healthcare providers

British Journal of Clinical Pharmacology, EarlyView.
Aims Hypertension is a leading modifiable risk factor for cardiovascular mortality worldwide. This study aimed to evaluate 25‐year trends in antihypertensive agent (AHA) utilization in Croatia between 2000 and 2024. Methods We conducted a national, population‐based analysis using IMS and IQVIA pharmaceutical databases.
Andrej Belančić, Marta Kučan Štiglić, Ana Jelaković, Bojan Jelaković, Dinko Vitezić   +4 more
wiley   +1 more source

Bench‐Stable Boryl Thianthrenium Dication Enables Aziridinyl Boronate Synthesis via Metal‐Free Late‐Stage Aziridination with Diverse Nitrogen Nucleophiles

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
A bench‐stable boryl thianthrenium dication is synthesized via thianthrenation of vinyl MIDA boronate. This novel dication enables metal‐free, chemo‐, and diastereoselective late‐stage aziridination with diverse nitrogen nucleophiles. The strategic significance is further showcased by one‐pot electrochemical and asymmetric protocols and versatile ...
Veerabhadra R. Vulupala, Disni Gunasekera, Nagarjun R. Mallampudi, Ramy Yousef, Yusif I. Gyasi, Gopal R. Ramidi, Ifeoluwa Adedotun, Shiqing Xu   +7 more
wiley   +2 more sources