Results 51 to 60 of about 624,952 (297)

Hydrogen storage in complex hydrides: past activities and new trends [PDF]

, 2022
Erika Michela Dematteis, Mads B. Amdisen, Tom Autrey, Jussara Barale, Mark Bowden, Craig E. Buckley, Young Whan Cho, Stefano Deledda, Martin Dornheim, Petra E. de Jongh, Jakob B. Grinderslev, Gökhan Gizer, Valerio Gulino, Bjørn C. Hauback, Michael Heere, Tae Wook Heo, Terry D. Humphries, Torben R. Jensen, ShinYoung Kang, Young‐Su Lee, Haiwen Li, Sichi Li, Kasper T. Møller, Peter Ngene, Shin‐ichi Orimo, Mark Paskevicius, Marek Polański, Shigeyuki Takagi, Liwen F. Wan, Brandon C. Wood, Michael Hirscher, Marcello Baricco   +31 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Internal lattice oxygen sites invert product selectivity in electrocatalytic alkyne hydrogenation over copper catalysts

Nature Communications
Copper-based catalysts exhibit excellent performance of electrocatalytic alkynes hydrogenation, especially for the selective alkynes hydrogenation toward alkenes.
Mengyu Li, Yimin Jiang, Wei Chen, Yucheng Huang, Yingrui Lu, Leitao Xu, Shengkai Li, Yandong Wu, Zhongcheng Xia, Ruiqi Wang, Shuangyin Wang, Yuqin Zou   +11 more
doaj   +1 more source

Characterization of Hydrogenated Natural Rubber Synthesized by Diimide Transfer Hydrogenation

International Journal of Technology, 2017
Oxidation resistance and thermal stability of natural rubber (NR) can be improved by diimide transfer hydrogenation in the latex phase. In this research, non-catalytic diimide transfer hydrogenation of concentrated NR latex was accomplished at various ...
Adi Cifriadi, Mochamad Chalid, Santi Puspitasari   +2 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

"Emulsifier-regulated synthesis of nitrile rubber and its catalytic hydrogenation in emulsion"

Hecheng xiangjiao gongye
The primary challenge in emulsion hydrogenation resides in maintaining emulsion stability under specific temperature and pressure conditions. This study proposed a strategy involving the incorporation of emulsifiers during the hydrogenation process to ...
GUO Zong-lei1 a, YU Ming-ming2, LI Yan-yan1 b, WANG Hui1 a, WANG Cheng-dong1 a
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source