Results 1 to 10 of about 157,550 (314)

Illuminating a biologics development challenge: systematic characterization of CHO cell-derived hydrolases identified in monoclonal antibody formulations [PDF]

mAbs
Monoclonal antibodies (mAb) and other biological drugs are affected by enzymatic polysorbate (PS) degradation that reduces product stability and jeopardizes the supply of innovative medicines.
Melanie Maier, Linus Weiß, Nikolas Zeh, Valerie Schmieder-Todtenhaupt, Alireza Dehghani, Marius Nicolaus Felix, Daniel Heinzelmann, Benjamin Lindner, Moritz Schmidt, Joey Studts, Patrick Schulz, Bernd Reisinger, Kerstin Otte, Matthias Franzreb, Daniel Lakatos, Simon Fischer   +15 more
doaj   +2 more sources

Role of Seasonality and Fire in Regulating the Enzymatic Activities in Soils Covered by Different Vegetation in a Mediterranean Area

Applied Sciences, 2021
As they quickly respond to environmental conditions, soil enzymes, involved in nutrient cycles, are considered good indicators of soil quality. The Mediterranean area is a peculiar environment for climatic conditions and for fire frequency.
Valeria Memoli, Lucia Santorufo, Giorgia Santini, Paola Musella, Rossella Barile, Anna De Marco, Gabriella Di Natale, Marco Trifuoggi, Giulia Maisto   +8 more
doaj   +1 more source

Biochemical and Multi-Omics Approaches To Obtain Molecular Insights into the Catabolism of the Plasticizer Benzyl Butyl Phthalate in Rhodococcus sp. Strain PAE-6

Microbiology Spectrum, 2023
Phthalate diesters are extensively used as plasticizers in manufacturing plastic materials; however, because of their estrogenic properties, these chemicals have emerged as a global threat to human health.
Suman Basu, Rinita Dhar, Mousumi Bhattacharyya, Tapan K. Dutta   +3 more
doaj   +1 more source

Epoxide Hydrolase Inhibitors for the Treatment of Alzheimer's Disease and Other Neurological Disorders: A Comprehensive Review. [PDF]

Biomedicines
Abdalla M, Ibrahim M, Alkorbi N, Alkuwari S, Pedersen S, Rathore HA.   +5 more
europepmc   +3 more sources

Screening of halotolerant microfungi isolated from hypersaline soils of Algerian Sahara for production of hydrolytic enzymes

Journal of Biological Research, 2021
The Algerian Sahara contains numerous hypersaline ecosystems including salt lakes in which the fungal diversity has not been characterized. The abundance and diversity of soil microofungi in three salt lakes in southeastern Algeria was investigated ...
Wassila Dendouga, Mohamed Belhamra
doaj   +1 more source

Induction and Repression of Hydrolase Genes in Aspergillus oryzae

Frontiers in Microbiology, 2021
The filamentous fungus Aspergillus oryzae, also known as yellow koji mold, produces high levels of hydrolases such as amylolytic and proteolytic enzymes. This property of producing large amounts of hydrolases is one of the reasons why A.
Mizuki Tanaka, Katsuya Gomi
doaj   +1 more source

A Hydrolase Produced by Rhodococcus erythropolis HQ Is Responsible for the Detoxification of Zearalenone

Toxins, 2023
Zearalenone (ZEN), an estrogenic mycotoxin, is one of the prevalent contaminants found in food and feed, posing risks to human and animal health. In this study, we isolated a ZEN-degrading strain from soil and identified it as Rhodococcus erythropolis HQ.
Junqiang Hu, Shilong Du, Han Qiu, Yuzhuo Wu, Qing Hong, Gang Wang, Sherif Ramzy Mohamed, Yin-Won Lee, Jianhong Xu   +8 more
doaj   +1 more source

Characterization of Some Salt-Tolerant Bacterial Hydrolases with Potential Utility in Cultural Heritage Bio-Cleaning

Microorganisms, 2022
Salt-tolerant enzymes produced by halophilic and halotolerant microorganisms have been proposed to be used in various applications that involve high saline conditions.
Robert Ruginescu, Madalin Enache, Octavian Popescu, Ioana Gomoiu, Roxana Cojoc, Costin Batrinescu-Moteau, Gabriel Maria, Maria Dumbravician, Simona Neagu   +8 more
doaj   +1 more source

Predicting Bacteriophage Enzymes and Hydrolases by Using Combined Features

Frontiers in Bioengineering and Biotechnology, 2020
Bacteriophage is a type of virus that could infect the host bacteria. They have been applied in the treatment of pathogenic bacterial infection. Phage enzymes and hydrolases play the most important role in the destruction of bacterial cells.
Hong-Fei Li, Hong-Fei Li, Xian-Fang Wang, Hua Tang   +3 more
doaj   +1 more source

Characterisation of a Novel Acetyl Xylan Esterase (BaAXE) Screened from the Gut Microbiota of the Common Black Slug (Arion ater)

Molecules, 2022
Acetyl xylan esterases (AXEs) are enzymes capable of hydrolysing the acetyl bonds in acetylated xylan, allowing for enhanced activity of backbone-depolymerizing enzymes.
Henry Madubuike, Natalie Ferry
doaj   +1 more source