Results 11 to 20 of about 130,442 (303)

Electrostatic Interaction with the Bacterial Cell Envelope Tunes the Lytic Activity of Two Novel Peptidoglycan Hydrolases

open access: yesMicrobiology Spectrum, 2022
Peptidoglycan (PG) hydrolases, due to their crucial role in the metabolism of the bacterial cell wall (CW), are increasingly being considered suitable targets for therapies, and a potent alternative to conventional antibiotics.
Alicja Wysocka   +3 more
doaj   +1 more source

Tweaking of Peripheral Moieties in Catalytic Amyloid for Modulating Hydrogel Strength and Hydrolase Activity

open access: yesChemistry, 2023
The de novo design and synthesis of peptide-based biocatalysts that can mimic the activity of natural enzymes is an exciting field with unique opportunities and challenges.
Soumya Patra   +4 more
doaj   +1 more source

Enzymatic Modification of Pomace Olive Oil with Natural Antioxidants: Effect on Oxidative Stability

open access: yesBiomolecules, 2023
Enzymatic lipophilization has been proposed as a cost-effective strategy to produce new liposoluble antioxidant compounds. In this study, modified oils rich in structured phenolipids were prepared via one-pot enzymatic acylation of hydroxytyrosol (HTYR),
Renia Fotiadou   +5 more
doaj   +1 more source

Lipoamidase is a multiple hydrolase [PDF]

open access: yesBiochemical Journal, 1990
The substrate specificity of lipoamidase, purified from the pig brain membrane with lipoyl 4-aminobenzoate (LPAB) as a substrate, was extensively studied. This single polypeptide was found to hydrolyse the bonding between amide, ester and peptide compounds. However, stringent structural requirements were found in the substrates, e.g.
J Oizumi, K Hayakawa
openaire   +3 more sources

An inhibitor/anti-inhibitor system controls the activity of lytic transglycosylase MltF in Pseudomonas aeruginosa

open access: yesmBio, 2023
Most bacterial cell envelopes contain a cell wall layer made of peptidoglycan. The synthesis of new peptidoglycan is critical for cell growth, division, and morphogenesis and is also coordinated with peptidoglycan hydrolysis to accommodate the new ...
Michelle Wang   +2 more
doaj   +1 more source

Evolutionary divergence and functions of the human acyl-CoA thioesterase gene (ACOT) family

open access: yesHuman Genomics, 2010
The acyl-CoA thioesterase gene (ACOT) family encodes enzymes that catalyse the hydrolysis of acyl-CoA thioester compounds, also known as activated fatty acids, to their corresponding non-esterified (free) fatty acid and coenzyme A (CoASH).
Brocker Chad   +3 more
doaj   +1 more source

Characterization of Some Salt-Tolerant Bacterial Hydrolases with Potential Utility in Cultural Heritage Bio-Cleaning

open access: yesMicroorganisms, 2022
Salt-tolerant enzymes produced by halophilic and halotolerant microorganisms have been proposed to be used in various applications that involve high saline conditions.
Robert Ruginescu   +8 more
doaj   +1 more source

Mammalian soluble epoxide hydrolase is identical to liver hepoxilin hydrolase [PDF]

open access: yesJournal of Lipid Research, 2011
Hepoxilins are lipid signaling molecules derived from arachidonic acid through the 12-lipoxygenase pathway. These trans-epoxy hydroxy eicosanoids play a role in a variety of physiological processes, including inflammation, neurotransmission, and formation of skin barrier function.
Cronin, A, Decker, M, Arand, Michael
openaire   +5 more sources

A Hydrolase Produced by Rhodococcus erythropolis HQ Is Responsible for the Detoxification of Zearalenone

open access: yesToxins, 2023
Zearalenone (ZEN), an estrogenic mycotoxin, is one of the prevalent contaminants found in food and feed, posing risks to human and animal health. In this study, we isolated a ZEN-degrading strain from soil and identified it as Rhodococcus erythropolis HQ.
Junqiang Hu   +8 more
doaj   +1 more source

A fast, miniaturised in-vitro assay developed for quantification of lipase enzyme activity

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2019
The discovery of allosteric modulators is a multi-disciplinary approach, which is time- and cost-intensive. High-throughput screening combined with novel computational tools can reduce these factors. Thus, we developed an enzyme activity assay, which can
Ariane Menden   +7 more
doaj   +1 more source

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