Results 21 to 30 of about 297,801 (378)

Metabolite Damage and Damage Control in a Minimal Genome

mBio, 2022
Analysis of the genes retained in the minimized Mycoplasma JCVI-Syn3A genome established that systems that repair or preempt metabolite damage are essential to life. Several genes known to have such functions were identified and experimentally validated,
Drago Haas, Antje M. Thamm, Jiayi Sun, Lili Huang, Lijie Sun, Guillaume A. W. Beaudoin, Kim S. Wise, Claudia Lerma-Ortiz, Steven D. Bruner, Marian Breuer, Zaida Luthey-Schulten, Jiusheng Lin, Mark A. Wilson, Greg Brown, Alexander F. Yakunin, Inna Kurilyak, Jacob Folz, Oliver Fiehn, John I. Glass, Andrew D. Hanson, Christopher S. Henry, Valérie de Crécy-Lagard   +21 more
doaj   +1 more source

Electrostatic Interaction with the Bacterial Cell Envelope Tunes the Lytic Activity of Two Novel Peptidoglycan Hydrolases

Microbiology Spectrum, 2022
Peptidoglycan (PG) hydrolases, due to their crucial role in the metabolism of the bacterial cell wall (CW), are increasingly being considered suitable targets for therapies, and a potent alternative to conventional antibiotics.
Alicja Wysocka, Łukasz Łężniak, Elżbieta Jagielska, Izabela Sabała   +3 more
doaj   +1 more source

The phytopathogenic fungus Sclerotinia sclerotiorum detoxifies plant glucosinolate hydrolysis products via an isothiocyanate hydrolase

Nature Communications, 2020
Brassicales plants produce glucosinolates and myrosinases that generate toxic isothiocyanates conferring broad resistance against pathogens and herbivorous insects.
Jingyuan Chen, C. Ullah, M. Reichelt, F. Beran, Zhi-Ling Yang, J. Gershenzon, A. Hammerbacher, D. G. Vassão   +7 more
semanticscholar   +1 more source

Evolutionary divergence and functions of the human acyl-CoA thioesterase gene (ACOT) family

Human Genomics, 2010
The acyl-CoA thioesterase gene (ACOT) family encodes enzymes that catalyse the hydrolysis of acyl-CoA thioester compounds, also known as activated fatty acids, to their corresponding non-esterified (free) fatty acid and coenzyme A (CoASH).
Brocker Chad, Carpenter Christopher, Nebert Daniel W, Vasiliou Vasilis   +3 more
doaj   +1 more source

Both ADP-Ribosyl-Binding and Hydrolase Activities of the Alphavirus nsP3 Macrodomain Affect Neurovirulence in Mice

mBio, 2020
Viral encephalomyelitis is an important cause of long-term disability, as well as acute fatal disease. Identifying viral determinants of outcome helps in assessing disease severity and developing new treatments. Mosquito-borne alphaviruses infect neurons
Rachy Abraham, R. McPherson, Morgan Dasovich, M. Badiee, A. Leung, D. Griffin   +5 more
semanticscholar   +1 more source

Basal and inducible anti-inflammatory epoxygenase activity in endothelial cells [PDF]

, 2014
The roles of CYP lipid-metabolizing pathways in endothelial cells are poorly understood. Human endothelial cells expressed CYP2J2 and soluble epoxide hydrolase (sEH) mRNA and protein.
Ara A. Askari, Askari, Baum, Bishop-Bailey, Bouis, Bystrom, Bystrom, Campbell, Capdevila, Darryl C. Zeldin, David Bishop-Bailey, Deng, Falck, Fang, Fred B. Lih, Hercule, Hwang, Imig, Jung, Lauterbach, Lee, Loppnow, Luo, Matthew L. Edin, Morisseau, Piqueras, Piqueras, Revermann, Schuchardt, Scott Thomson, Spiecker, Vinay, Zeldin, Zeldin, Zeldin, Zhang   +35 more
core   +1 more source

Lipopolysaccharide-specific acyloxyacyl hydrolase [PDF]

, 1991
" An acyloxyacyl hydrolase from the human promyelocyte cell line HL-60 has been found to specifically hydrolyze fatty acids from their ester linkages to hydroxy groups of 3-hydroxyfatty acids, the latter being being bound in turn to lipopolysaccharide ...
Hall, Catherine L., Munford, Robert S.
core   +1 more source

An inhibitor/anti-inhibitor system controls the activity of lytic transglycosylase MltF in Pseudomonas aeruginosa

mBio, 2023
Most bacterial cell envelopes contain a cell wall layer made of peptidoglycan. The synthesis of new peptidoglycan is critical for cell growth, division, and morphogenesis and is also coordinated with peptidoglycan hydrolysis to accommodate the new ...
Michelle Wang, Sheya Xiao Ma, Andrew J. Darwin   +2 more
doaj   +1 more source

Taxonomic profiling and populational patterns of bacterial bile salt hydrolase (BSH) genes based on worldwide human gut microbiome

Microbiome, 2019
Bile salt hydrolase plays an important role in bile acid-mediated signaling pathways, which regulate lipid absorption, glucose metabolism, and energy homeostasis.
Ziwei Song, Yuanyuan Cai, Xingzhen Lao, Xue Wang, Xiaoxuan Lin, Yingyun Cui, P. Kalavagunta, Jun Liao, Liang Jin, Jing Shang, Jing Li   +10 more
semanticscholar   +1 more source

The Unusual Substrate Specificity of a Virulence Associated Serine Hydrolase from the Highly Toxic Bacterium, \u3cem\u3eFrancisella tularensis\u3c/em\u3e [PDF]

, 2016
Francisella tularensis is the causative agent of the highly, infectious disease, tularemia. Amongst the genes identified as essential to the virulence of F. tularensis was the proposed serine hydrolase FTT0941c.
Farberg, Alexander M., Hart, Whitney K., Johnson, R. Jeremy   +2 more
core   +2 more sources