Results 31 to 40 of about 130,442 (303)
New Insights Into Human Hyaluronidase 4/Chondroitin Sulphate Hydrolase
Frontiers in Cell and Developmental Biology, 2021 In this review, the current experimental evidence, literature and hypotheses surrounding hyaluronidase 4 [HYAL4, also known as chondroitin sulphate hydrolase (CHSE)] and chondroitin sulphate (CS) are explored. Originally named for its sequence similarity
Marissa L. Maciej-Hulme
doaj +1 more source
Study on the Degradation Effect of Three Organophosphorus Hydrolase Mutant on Sarin [PDF]
E3S Web of Conferences, 2021 Organophosphorus hydrolase can effectively degrade organic phosphorus compounds such as sarin. In this study, we constructed a recombinant Bacillus subtilis mutant expressing organophosphorus hydrolase, measured the effect of the mutant on the ...
Gu Qiamin +4 more
doaj +1 more source
Machine learning on DNA-encoded libraries: A new paradigm for hit-finding [PDF]
, 2020 DNA-encoded small molecule libraries (DELs) have enabled discovery of novel inhibitors for many distinct protein targets of therapeutic value through screening of libraries with up to billions of unique small molecules. We demonstrate a new approach applying machine learning to DEL selection data by identifying active molecules from a large commercial ...
arxiv +1 more source
Enhanced Response of a Proteinase K-Based Conductometric Biosensor Using Nanoparticles
Sensors, 2014 Proteinases are involved in a multitude of important physiological processes, such as protein metabolism. For this reason, a conductometric enzyme biosensor based on proteinase K was developed using two types of nanoparticles (gold and magnetic).
Wided Nouira +5 more
doaj +1 more source
IFN-Induced PARPs—Sensors of Foreign Nucleic Acids?
Pathogens, 2023 Cells have developed different strategies to cope with viral infections. Key to initiating a defense response against viruses is the ability to distinguish foreign molecules from their own. One central mechanism is the perception of foreign nucleic acids
Katharina Biaesch +2 more
doaj +1 more source
Diffusion-based Molecule Generation with Informative Prior Bridges [PDF]
arXiv, 2022 AI-based molecule generation provides a promising approach to a large area of biomedical sciences and engineering, such as antibody design, hydrolase engineering, or vaccine development. Because the molecules are governed by physical laws, a key challenge is to incorporate prior information into the training procedure to generate high-quality and ...
arxiv
GGH (gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on GGH (gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase), with data on DNA, on the protein encoded, and where the gene is implicated.
Cheng, Q, Evans, WE
openaire +3 more sources
Angewandte Chemie, Volume 134, Issue 51, December 19, 2022., 2022 Corramycin ist ein neuer Naturstoff, welcher von dem Myxobakterium Corallococcus coralloides produziert wird. Seine Struktur sowie die außergewöhnliche Total‐ und Biosynthese des Antibiotikums werden hier zum ersten Mal beschrieben. Corramycin zeigt keine Zytotoxizität und keine Kreuzresistenz mit gängigen Antibiotikaklassen.
Cédric Couturier +32 more
wiley +1 more source
Purification, Characterization, and Structural Studies of a Sulfatase from Pedobacter yulinensis
Molecules, 2021 Sulfatases are ubiquitous enzymes that hydrolyze sulfate from sulfated organic substrates such as carbohydrates, steroids, and flavones. These enzymes can be exploited in the field of biotechnology to analyze sulfated metabolites in humans, such as ...
Caleb R. Schlachter +5 more
doaj +1 more source
Enzyme Similarity Networks [PDF]
arXiv, 2022 There is a crescent use of enzymes in multiple industries and sciences, ranging from materials and fuel synthesis to pharmaceutical and food production. Their applicability in this variety of fields depends not only on their biochemical function but also on their physicochemical properties.
arxiv