A selective gut bacterial bile salt hydrolase alters host metabolism
eLife, 2018 The human gut microbiota impacts host metabolism and has been implicated in the pathophysiology of obesity and metabolic syndromes. However, defining the roles of specific microbial activities and metabolites on host phenotypes has proven challenging due
Lina Yao +8 more
semanticscholar +1 more source
Food Technology and Biotechnology, 2015 In this study, ultrasound- and enzyme-assisted extractions of albumin (water-soluble protein group) from defatted pumpkin (Cucurbita pepo) seed powder were compared.
Gia Loi Tu +4 more
doaj +1 more source
Molecular Neurodegeneration, 2019 Haploinsufficiency in the Gaucher disease GBA gene, which encodes the lysosomal glucocerebrosidase GBA, and ageing represent major risk factors for developing Parkinson’s disease (PD).
Mylene Huebecker +6 more
semanticscholar +1 more source
Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB/W F1 mice [PDF]
, 2019 Epoxy-fatty-acids (EpFAs), cytochrome P450 dependent arachidonic acid derivatives, have been suggested to have anti-inflammatory properties, though their effects on autoimmune diseases like systemic lupus erythematosus (SLE) have yet to be investigated ...
Dragun, Duska +9 more
core +2 more sources
Expression, purification, crystallization and preliminary X-ray diffraction analysis of conjugated bile salt hydrolase from Bifidobacterium longum [PDF]
, 2004 Conjugated bile salt hydrolase (BSH) catalyses the hydrolysis of the amide bond that conjugates bile acids to glycine and to taurine. The BSH enzyme from Bifidobacterium longum was overexpressed in Escherichia coli BL21(DE3), purified and crystallized ...
Brannigan, J A +5 more
core +5 more sources
Identification of tunnels as in potato hydrolases [PDF]
Bioinformation, 2020 Enzymes with an active center hidden in the middle of the molecule in a tunnel-like cavity constitute an interesting object of analysis due to the highly specialized environment for the course of the catalytic reaction. Identifying the tunnel is a challenge in itself.
Banach, Mateusz +4 more
openaire +3 more sources
Intimal smooth muscle cells are a source but not a sensor of anti-inflammatory CYP450 derived oxylipins [PDF]
, 2015 Vascular pathologies are associated with changes in the presence and expression of morphologically distinct vascular smooth muscle cells. In particular, in complex human vascular lesions and models of disease in pigs and rodents, an intimal smooth muscle
Arnold +46 more
core +2 more sources
Study on the Degradation Effect of Three Organophosphorus Hydrolase Mutant on Sarin [PDF]
E3S Web of Conferences, 2021 Organophosphorus hydrolase can effectively degrade organic phosphorus compounds such as sarin. In this study, we constructed a recombinant Bacillus subtilis mutant expressing organophosphorus hydrolase, measured the effect of the mutant on the ...
Gu Qiamin +4 more
doaj +1 more source
The Urea Carboxylase and Allophanate Hydrolase Activities of Urea Amidolyase Are Functionally Independent [PDF]
, 2016 Urea amidolyase (UAL) is a multifunctional biotin-dependent enzyme that contributes to both bacterial and fungal pathogenicity by catalyzing the ATP-dependent cleavage of urea into ammonia and CO2.
Bahler +48 more
core +2 more sources
New Insights Into Human Hyaluronidase 4/Chondroitin Sulphate Hydrolase
Frontiers in Cell and Developmental Biology, 2021 In this review, the current experimental evidence, literature and hypotheses surrounding hyaluronidase 4 [HYAL4, also known as chondroitin sulphate hydrolase (CHSE)] and chondroitin sulphate (CS) are explored. Originally named for its sequence similarity
Marissa L. Maciej-Hulme
doaj +1 more source