Results 41 to 50 of about 151,216 (363)
Interlinked GTPase cascades provide a motif for both robust switches and oscillators [PDF]
J. R. Soc. Interface 16, 20190198 (2019), 2019 GTPases regulate a wide range of cellular processes, such as intracellular vesicular transport, signal transduction, and protein translation. These hydrolase enzymes operate as biochemical switches by toggling between an active guanosine triphosphate (GTP)-bound state and an inactive guanosine diphosphate (GDP)-bound state.
arxiv +1 more source
Effet de la pectolyase Y-23 et de la cellulase Onozuka RS sur le rendement en protoplastes viables de Prunus cerasus L. [PDF]
Biotechnologie, Agronomie, Société et Environnement, 2001 Effect of pectolyase Y-23 and cellulase Onozuka RS on the yield of viable protoplasts of Prunus cerasus L. ""Montmorency"". To isolate leaf mesophyll, leaf and root callus protoplasts of Prunus cerasus L.
Mehri-Kamoun R.
doaj
Identification of tunnels as in potato hydrolases [PDF]
Bioinformation, 2020 Enzymes with an active center hidden in the middle of the molecule in a tunnel-like cavity constitute an interesting object of analysis due to the highly specialized environment for the course of the catalytic reaction. Identifying the tunnel is a challenge in itself.
Banach, Mateusz +4 more
openaire +3 more sources
New families in the classification of glycosyl hydrolases based on amino acid sequence similarities.
Biochemical Journal, 1993 301 glycosyl hydrolases and related enzymes corresponding to 39 EC entries of the I.U.B. classification system have been classified into 35 families on the basis of amino-acid-sequence similarities [Henrissat (1991) Biochem. J.
B. Henrissat, A. Bairoch
semanticscholar +1 more source
Machine learning on DNA-encoded libraries: A new paradigm for hit-finding [PDF]
, 2020 DNA-encoded small molecule libraries (DELs) have enabled discovery of novel inhibitors for many distinct protein targets of therapeutic value through screening of libraries with up to billions of unique small molecules. We demonstrate a new approach applying machine learning to DEL selection data by identifying active molecules from a large commercial ...
arxiv +1 more source
Diffusion-based Molecule Generation with Informative Prior Bridges [PDF]
arXiv, 2022 AI-based molecule generation provides a promising approach to a large area of biomedical sciences and engineering, such as antibody design, hydrolase engineering, or vaccine development. Because the molecules are governed by physical laws, a key challenge is to incorporate prior information into the training procedure to generate high-quality and ...
arxiv
GGH (gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on GGH (gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase), with data on DNA, on the protein encoded, and where the gene is implicated.
Cheng, Q, Evans, WE
openaire +3 more sources
Angewandte Chemie, Volume 134, Issue 51, December 19, 2022., 2022 Corramycin ist ein neuer Naturstoff, welcher von dem Myxobakterium Corallococcus coralloides produziert wird. Seine Struktur sowie die außergewöhnliche Total‐ und Biosynthese des Antibiotikums werden hier zum ersten Mal beschrieben. Corramycin zeigt keine Zytotoxizität und keine Kreuzresistenz mit gängigen Antibiotikaklassen.
Cédric Couturier +32 more
wiley +1 more source
Enzyme Similarity Networks [PDF]
arXiv, 2022 There is a crescent use of enzymes in multiple industries and sciences, ranging from materials and fuel synthesis to pharmaceutical and food production. Their applicability in this variety of fields depends not only on their biochemical function but also on their physicochemical properties.
arxiv
Development of a Covalent Inhibitor of Gut Bacterial Bile Salt Hydrolases
bioRxiv, 2019 Bile salt hydrolase (BSH) enzymes are widely expressed by human gut bacteria and catalyze the gateway reaction leading to secondary bile acid formation. Bile acids regulate key metabolic and immune processes by binding to host receptors.
Arijit A. Adhikari +13 more
semanticscholar +1 more source