Results 11 to 20 of about 7,137 (263)

Hydroxocobalamin as Rescue Therapy in a Patient With Refractory Amlodipine-Induced Vasoplegia [PDF]

Cureus, 2023
Vasoplegic syndrome is a type of distributive shock characterized by mean arterial pressure of less than 65 mmHg, with normal to high cardiac output and often refractory to fluid resuscitation, high doses of intravenous vasopressors, and inotropes. It is
Laith A Ayasa, Jehad Azar, Anas Odeh, Mohammed Ayyad, Sara Shbaita, Thabet Zidan, Noor Al-deen Awwad, Nagham M Kawa, Wafaa Hassan Ali Awad   +8 more
openalex   +2 more sources

Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study [PDF]

Critical Care, 2019
Background The use of hydroxocobalamin has long been advocated for treating suspected cyanide poisoning after smoke inhalation. Intravenous hydroxocobalamin has however been shown to cause oxalate nephropathy in a single-center study.
François Dépret, Clément Hoffmann, Laura Daoud, Camille Thieffry, Laure Monplaisir, Jules Creveaux, Djillali Annane, Erika Parmentier, Daniel Mathieu, Sandrine Wiramus, Dominique Demeure DIt Latte, Aubin Kpodji, Julien Textoris, Florian Robin, Kada Klouche, Emmanuel Pontis, Guillaume Schnell, François Barbier, Jean-Michel Constantin, Thomas Clavier, Damien du Cheyron, Nicolas Terzi, Bertrand Sauneuf, Emmanuel Guerot, Thomas Lafon, Alexandre Herbland, Bruno Megarbane, Thomas Leclerc, Vincent Mallet, Romain Pirracchio, Matthieu Legrand   +30 more
doaj   +2 more sources

The Durability of Intravenous Hydroxocobalamin in Vasoplegia

Cureus, 2023
Objectives Refractory distributive shock (vasoplegia) has been treated with intravenous (IV) hydroxocobalamin (B12), but its use is poorly characterized. The objective of this study was to quantify the duration of hemodynamic improvement after B12 administration. Materials and methods This was a retrospective chart review of adult patients who received
Blaha, Madeline, Blais, Meghan, Olson, Logan   +2 more
openaire   +3 more sources

A double-blind, randomized, comparative study of the use of a combination of uridine triphosphate trisodium, cytidine monophosphate disodium, and hydroxocobalamin, versus isolated treatment with hydroxocobalamin, in patients presenting with compressive neuralgias [PDF]

Journal of Pain Research, 2017
Henrique Goldberg,1 Marco Antonio Mibielli,2 Carlos Pereira Nunes,2 Stephanie Wrobel Goldberg,3 Luiz Buchman,4 Spyros GE Mezitis,5 Helio Rzetelna,6 Lisa Oliveira,2 Mauro Geller,2 Fernanda Wajnsztajn7 1UERJ Medical School, Rio de Janeiro, Brazil; 2UNIFESO
Goldberg H, Mibielli MA, Nunes CP, Goldberg SW, Buchman L, Mezitis SG, Rzetelna H, Oliveira L, Geller M, Wajnsztajn F   +9 more
doaj   +3 more sources

Improved biochemical and neurodevelopmental profiles with high‐dose hydroxocobalamin therapy in cobalamin C defect

Journal of Inherited Metabolic Disease, Volume 48, Issue 1, January 2025.
Abstract Cobalamin C (Cbl‐C) defect causes methylmalonic acidemia, homocystinuria, intellectual disability and visual impairment, despite treatment adherence. While international guidelines recommend parenteral hydroxocobalamin (OH‐Cbl) as effective treatment, dose adjustments remain unclear.
Giorgia Olivieri, Benedetta Greco, Sara Cairoli, Giulio Catesini, Francesca Romana Lepri, Lorenzo Orazi, Maria Mallardi, Diego Martinelli, Daniela Ricci, Raffaele Simeoli, Carlo Dionisi‐Vici   +10 more
wiley   +2 more sources

Intramuscular Vitamin B12 Treatment in Transcobalamin II Deficiency: Case Series Clinical Outcomes [PDF]

The Application of Clinical Genetics
Ali M Sawlan,1 Msaed Alotaibi,1 Rayan M Alharbi,1 Nimr A Alwahbi,1 Manar Alshammary,2 Ali Mohammad Alasmari,2 Fuad Al Mutairi3,4 1College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs (MNG ...
Sawlan AM, Alotaibi M, Alharbi RM, Alwahbi NA, Alshammary M, Alasmari AM, Al Mutairi F   +6 more
doaj   +2 more sources

Severe Vasoplegic Syndrome Treated with Angiotensin II and Hemoadsorption Therapy after Cardiac Surgery. [PDF]

Catheter Cardiovasc Interv
ABSTRACT Vasoplegic syndrome (VS) is a common complication after cardiac surgery with cardiopulmonary bypass (CPB). The main pathophysiology mechanism of VS includes a systemic inflammatory response syndrome due to surgical trauma, release of pro‐inflammatory mediators caused by blood contact with foreign surfaces of heart‐lung machine (pump and tubing)
Lucchelli M, Andreis DT, Gomarasca M, Mistraletti G.   +3 more
europepmc   +2 more sources

Effect of hydroxocobalamin on nimodipine-induced refractory vasoplegia in a patient with liver cirrhosis: a case report [PDF]

Journal of Neurocritical Care
Background We report a case of severe vasoplegia that was unresponsive to triple vasopressor therapy but showed marked hemodynamic improvement following intravenous hydroxocobalamin administration in a patient with underlying cirrhosis.
Sally You
doaj   +2 more sources

Clinical diagnosis, treatment, and genetic analysis of adolescent onset holocarboxylase synthetase deficiency and cobalamin C deficiency: A case report and literature review [PDF]

Metabolism Open
Background: Holocarboxylase Synthetase Deficiency (HCSD) is an uncommon autosomal recessive genetic disorder that manifests with symptoms such as metabolic acidosis, lethargy, hypotonia, seizures, and persistent rashes, typically emerging during infancy.
Ye Ren, Hongxing Dang, Yueqiang Fu, Chengjun Liu, Jing Li, Jinhua Cai   +5 more
doaj   +2 more sources

511 Hydroxocobalamin Not the Clear Culprit of Nephrotoxicity After Cyanide Poisoning [PDF]

J Burn Care Res
Introduction Inhalation injury (IHI) and cyanide poisoning are often observed in burn patients, but they may also present without cutaneous injury. If cyanide toxicity is suspected, the antidote, hydroxocobalamin, is indicated. Although a lifesaving drug,
Elise M Mann, A. Boyd, Todd A. Walroth, Jessica A. Whitten, Allyson M. McIntire, Serena A. Dine, M. Howell, Taylor Rhew, Brett C Hartman   +8 more
europepmc   +2 more sources