The availability of therapeutic hydroxocobalamin to cells [PDF]
Blood, 1984 Abstract Hydroxocobalamin (OH-Cbl), when used to treat vitamin B12 deficiency, is better retained by the body than is cyanocobalamin (CN-Cbl), but the availability to cells has not been studied systematically. In a series of experiments, we compared the uptake and internalization of OH-Cbl and CN-Cbl bound to transcobalamin II (TCII) by ...
Charles A. Hall +2 more
openaire +4 more sources
Management of hypotension in dihydropyridine calcium channel blocker overdose: The role of high-dose insulin therapy. [PDF]
Br J Clin PharmacolAims Amlodipine poisoning is a leading cause of cardiovascular medication‐related deaths, commonly managed with high‐dose insulin (HDI) therapy. However, HDI is a vasodilator that is counterproductive in managing vasoplegia. We aim to study HDI therapy in patients with hypotension following dihydropyridine calcium channel antagonist (CCA) overdose ...
Chan BSH +3 more
europepmc +2 more sources
A New, Atypical Case of Cobalamin F Disorder Diagnosed by Whole Exome Sequencing [PDF]
, 2015 The Deciphering Developmental Disorders Study presents independent research commissioned by the Health Innovation Challenge Fund (HICF-1009-003), a parallel funding partnership between the Wellcome Trust and the Department of Health, and the Wellcome ...
Constantinou, Panayiotis +6 more
core +1 more source
Transient Transcriptional Regulation of the CYS-C1 Gene and Cyanide Accumulation upon Pathogen Infection in the Plant Immune Response [PDF]
, 2013 Cyanide is produced concomitantly with ethylene biosynthesis. Arabidopsis (Arabidopsis thaliana) detoxifies cyanide primarily through the enzyme b-cyanoalanine synthase, mainly by the mitochondrial CYS-C1.
Bejarano, Eduardo R. +3 more
core +1 more source
Cyanide Production by Chromobacterium piscinae Shields It from Bdellovibrio bacteriovorus HD100 Predation [PDF]
, 2017 Predation of Chromobacterium piscinae by Bdellovibrio bacteriovorus HD100 was inhibited in dilute nutrient broth (DNB) but not in HEPES. Experiments showed that the effector responsible was present in the medium, as cell-free supernatants retained the ...
Aruldass +57 more
core +2 more sources
Hemodialysis Complications of Hydroxocobalamin: A Case Report [PDF]
Journal of Medical Toxicology, 2010 Hydroxocobalamin is a new antidote approved by the FDA for the treatment of cyanide poisoning. Our report describes a patient with cyanide poisoning who survived after treatment with hydroxocobalamin and complications we encountered with hemodialysis. A 34-year-old female presented to the emergency department after a syncopal event and seizures.
Sutter, Mark +3 more
openaire +5 more sources
Receiving a diagnosis of Pernicious Anaemia: exploring experiences of relationships with health professionals [PDF]
, 2019 Objectives: Pernicious Anaemia (PA) is a chronic condition caused by vitamin B12 deficiency. This is a qualitative study using interpretative phenomenological analysis (IPA); which aimed to explore the patients lived experience of diagnosis and ...
Glover, E., Mercer, Jenny, Seage, Heidi
core +1 more source
Protein dynamics in the reductive activation of a B12-containing enzyme [PDF]
, 2017 B12-dependent proteins are involved in methyl transfer reactions ranging from the biosynthesis of methionine in humans to the formation of acetyl-CoA in anaerobic bacteria.
Goetzl, Sebastian +6 more
core +1 more source
Biphasic Modulation of NOS Expression, Protein and Nitrite Products by Hydroxocobalamin Underlies Its Protective Effect in Endotoxemic Shock: Downstream Regulation of COX-2, IL-1 beta, TNF-alpha, IL-6, and HMGB1 Expression [PDF]
, 2013 Background. NOS/•NO inhibitors are potential therapeutics for sepsis, yet they increase clinical mortality. However, there has been no in vivo investigation of the (in vitro) •NO scavenger, cobalamin’s (Cbl) endogenous effects on NOS/•NO/inflammatory ...
Brancaleone, V +5 more
core +3 more sources
High-Dose Hydroxocobalamin for Refractory Vasoplegia Post Cardiac Surgery
Cureus, 2022 Administration of high-dose hydroxocobalamin, or vitamin B12, is an emerging, targeted rescue therapy for the treatment of refractory vasoplegic shock.
M. Bak +3 more
semanticscholar +1 more source