19-Hydroxyeicosatetraenoic acid analogs: Antagonism of 20-hydroxyeicosatetraenoic acid-induced vascular sensitization and hypertension. [PDF]
Bioorg Med Chem Lett, 2019 19-Hydroxyeicosatetraenoic acid (19-HETE, 1), a metabolically and chemically labile cytochrome P450 eicosanoid, has diverse biological activities including antagonism of the vasoconstrictor 20-hydroxyeicosatetraenoic acid (20-HETE, 2). A SAR study was conducted to develop robust analogs of 1 with improved in vitro and in vivo efficacy.
Dakarapu R +9 more
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Simvastatin inhibits 20-Hydroxyeicosatetraenoic acid formation: docking and in vitro assay [PDF]
BMC Pharmacology and ToxicologyIntroduction 20-Hydroxyeicosatetraenoic acid (20-HETE), a metabolite of arachidonic acid catalyzed mainly by cytochrome P450 (CYP) enzymes CYP4A11 and CYP4F2, plays a role in cardiovascular homeostasis.
Yazun Jarrar +6 more
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Study on the mechanism of 20-hydroxyeicosatetraenoic acid in retinal ischemia–reperfusion injury [PDF]
Indian Journal of OphthalmologyPurpose: To explore the effect of 20-hydroxyeicosatetraenoic acid (20-HETE) on retinal ischemia–reperfusion injury (RIRI) and the protective effect of N‐hydroxy‐N’‐(4‐n‐butyl‐2‐methylphenyl)formamidine (HET0016) on RIRI. Methods: Male Sprague–Dawley rats
Liang Lv, Li-Xiao Zhou, Fei-Fei Jiang
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Epoxyeicosatrienoic Acids and 20-Hydroxyeicosatetraenoic Acid on Endothelial and Vascular Function. [PDF]
Adv Pharmacol, 2016 Endothelial and vascular smooth cells generate cytochrome P450 (CYP) arachidonic acid metabolites that can impact endothelial cell function and vascular homeostasis. The objective of this review is to focus on the physiology and pharmacology of endothelial CYP metabolites.
Imig JD.
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Epoxyeicosatrienoic acids, 20-hydroxyeicosatetraenoic acid, and renal microvascular function. [PDF]
Prostaglandins Other Lipid Mediat, 2013 The development of pharmacological, genetic, and biochemical tools have allowed for detailed studies to determine the contribution of cytochrome P450 (CYP) metabolites of arachidonic acid to renal microvascular function. Renal microvessels can generate CYP hydroxylase metabolites including 20-hydroxyeicosatetraenoic acid (20-HETE) and CYP epoxygenase ...
Imig JD.
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20-hydroxyeicosatetraenoic acid, endothelial dysfunction and hypertension [PDF]
Medicinski Glasnik, 2011 20-hydroxyeicosatrienoic acid (20-HETE) is a metabolite of arachidonic acid formed by the enzymatic activity of cytochrome P450 omega hydroxylases of the 4A and 4F isoform families (CYP 450 4A and 4F). The role of the metabolites of arachidonic acid (AA)
Mary Pat Kunert, Ines Drenjančević
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Hypertension in People Exposed to Environmental Cadmium: Roles for 20-Hydroxyeicosatetraenoic Acid in the Kidney [PDF]
Journal of XenobioticsChronic kidney disease (CKD) has now reached epidemic proportions in many parts of the world, primarily due to the high incidence of diabetes and hypertension. By 2040, CKD is predicted to be the fifth-leading cause of years of life lost.
Soisungwan Satarug
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Localization of 12-hydroxyeicosatetraenoic acid in endothelial cells.
Journal of Lipid Research, 1990 Bovine aortic endothelial cells take up 12-hydroxyeicosatetraenoic acid (12-HETE), a lipoxygenase product formed from arachidonic acid. The uptake of [3H]12-HETE reached a maximum in 2 to 4 h.
LX Wang, TL Kaduce, AA Spector
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12(S)‐hydroxyeicosatetraenoic acid impairs vascular endothelial permeability by altering adherens junction phosphorylation levels and affecting the binding and dissociation of its components in high glucose‐induced vascular injury [PDF]
Journal of Diabetes Investigation, 2019 Aims/Introduction Diabetes is an important risk factor for atherosclerotic disease. The initiating factor of atherosclerosis is local endothelial cell injury.
Xiaofang Wang +7 more
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20-Hydroxyeicosatetraenoic acid (20-HETE) Modulates Canonical Transient Receptor Potential-6 (TRPC6) Channels in Podocytes [PDF]
Frontiers in Physiology, 2016 The arachidonic acid metabolite 20-hydroxyeicosatetraenoic acid (20-HETE) regulates renal function, including changes in glomerular function evoked during tubuloglomerular feedback (TGF).
Hila Roshanravan +3 more
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