Results 131 to 140 of about 6,850 (177)
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Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1985
Human umbilical arteries convert arachidonic acid into three hydroxy-eicosatetraenoic acids as well as 6-ketoprostaglandin F1 alpha, prostaglandins E2, F2 alpha and D2 and thromboxane B2. Two of these hydroxy derivatives of arachidonic acid were purified by reverse-phase HPLC and identified by GC-MS as 11-hydroxyeicosatetraenoic acid (11-HETE) and 15 ...
B N, Setty, M J, Stuart, R W, Walenga
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Human umbilical arteries convert arachidonic acid into three hydroxy-eicosatetraenoic acids as well as 6-ketoprostaglandin F1 alpha, prostaglandins E2, F2 alpha and D2 and thromboxane B2. Two of these hydroxy derivatives of arachidonic acid were purified by reverse-phase HPLC and identified by GC-MS as 11-hydroxyeicosatetraenoic acid (11-HETE) and 15 ...
B N, Setty, M J, Stuart, R W, Walenga
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Role of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrienoic acids in hypertension
Current Opinion in Nephrology and Hypertension, 2004Cytochrome P-450 metabolites of arachidonic acid have been reported to play an important role in the control of renal function and vascular tone, and in the long-term control of arterial pressure. In this regard, 20-hydroxyeicosatetraenoic acid is a potent vasoconstrictor that inhibits sodium reabsorption in the kidney.
Albert, Sarkis +2 more
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Promotion of adipogenesis by 15-(S)-hydroxyeicosatetraenoic acid
Prostaglandins & Other Lipid Mediators, 2016Excess adipogenesis is a characteristic of obesity, which is associated with serious health problem, including type 2 diabetes. Here, to better understand the mechanisms for the development of adipocytes, we investigated the regulatory role of 15-(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) in adipogenesis by treating 3T3-L1 murine preadipocytes and ...
Yong-Seok, Song +5 more
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Renal arterial 20-hydroxyeicosatetraenoic acid levels: regulation by cyclooxygenase
American Journal of Physiology-Renal Physiology, 200320-HETE, a potent vasoconstrictor, is generated by cytochrome P-450 ω-hydroxylases and is the principal eicosanoid produced by preglomerular microvessels. It is released from preglomerular microvessels by ANG II and is subject to metabolism by cyclooxygenase (COX).
Monica K, Cheng +2 more
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Formation of hydroxyeicosatetraenoic acids from hemozoin-catalyzed oxidation of arachidonic acid
Molecular and Biochemical Parasitology, 1996Hemozoin, a heme byproduct of hemoglobin digestion by malaria parasites, is released into the blood stream of the host upon lysing of infected erythrocytes. Since heme-compounds are potent catalysts of lipid peroxidation, we evaluated the catalytic ability of Plasmodium falciparum-derived hemozoin to oxidize arachidonic acid to hydroxyeicosatetraenoic ...
M D, Green, L, Xiao, A A, Lal
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Inhibitors of 20-Hydroxyeicosatetraenoic Acid Reduce Renal Vasoconstrictor Responsiveness
The Journal of Pharmacology and Experimental Therapeutics, 200320-Hydroxyeicosatetraenoic acid (20-HETE) is a cytochrome P450-derived constrictor eicosanoid produced by the preglomerular vasculature where it contributes to regulation of tone. Removal of the tonic inhibitory influence of nitric oxide (NO) has been reported to increase renal 20-HETE release.
J, Quilley, Y, Qiu, J, Hirt
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20-Hydroxyeicosatetraenoic acid causes endothelial dysfunction via eNOS uncoupling
American Journal of Physiology-Heart and Circulatory Physiology, 2008Nitric oxide (NO), generated from l-arginine by endothelial nitric oxide synthase (eNOS), is a key endothelial-derived factor whose bioavailability is essential to the normal function of the endothelium. Endothelium dysfunction is characterized by loss of NO bioavailability because of either reduced formation or accelerated degradation of NO.
Jennifer, Cheng +6 more
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Biological Mass Spectrometry, 1988
A direct mass spectrometric method for 15-hydroxy metabolites of arachidonic acid and of eicosapentaenoic acid is described. 15-Hydroxyeicosanoids have the capacity to inhibit the formation of leukotrienes, potent mediators of inflammation formed by the 5-lipoxygenase pathway of arachidonic acid metabolism and may therefore have anti-inflammatory ...
K, Fogh +4 more
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A direct mass spectrometric method for 15-hydroxy metabolites of arachidonic acid and of eicosapentaenoic acid is described. 15-Hydroxyeicosanoids have the capacity to inhibit the formation of leukotrienes, potent mediators of inflammation formed by the 5-lipoxygenase pathway of arachidonic acid metabolism and may therefore have anti-inflammatory ...
K, Fogh +4 more
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20-Hydroxyeicosatetraenoic acid involved in endothelial activation and thrombosis
American Journal of Physiology-Heart and Circulatory Physiology, 2015Endothelial cells play an important role in the process of coagulation and the function of platelets. We have previously reported that 20-hydroxyeicosatetraenoic acid (20-HETE), a metabolite of arachidonic acid, increased platelet aggregation and induced hemostasis. The purpose of the present study is to investigate whether 20-HETE-mediated endothelial
Jiaxing, Wang +10 more
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12-Hydroxyeicosatetraenoic acid reduces prostacyclin production by endothelial cells
Prostaglandins, 198612-Hydroxyeicosatetraenoic acid (12-HETE), a lipoxygenase product released by activated platelets and macrophages, reduced prostacyclin (PGI2) formation in bovine aortic endothelial cultures by as much as 70%. Maximal inhibition required 1 to 2 h to occur and after 2 hr, a concentration of 1 microM 12-HETE produced 80% of the maximum inhibitory effect.
C, Hadjiagapiou, A A, Spector
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