Results 141 to 150 of about 6,850 (177)

Inhibition of Adenylyl Cyclases by 12(S)-Hydroxyeicosatetraenoic Acid

Biochemical and Biophysical Research Communications, 1996
The inhibition of adenylyl cyclase (AC) by a 12-lipoxygenase metabolite of arachidonic acid, 12(S)-hydroxy-5Z,8Z,10E,14Z-eicosatetraenoic acid (12-HETE), was investigated using three different kinds of cells: NRK-49F (normal rat kidney fibroblasts), AtT-20 (mouse pituitary tumor cell line) and HL-60 (human leukemia cells) cells. The inhibition was very
X.-Q. Wang, M. Otsuka, J. Takagi, Y. Kobayashi, F. Sato, Y. Saito   +5 more
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Prostaglandin and hydroxyeicosatetraenoic acid synthesis by human mesenchymal tumors

International Journal of Cancer, 1985
AbstractThe metabolism of arachidonic acid was investigated by radioimmunoassay and chromatographic techniques in 5 sarcomas and one embryonal carcinoma of human origin maintained as transplantable tumors in nude mice. The results obtained indicate that: (1) the absolute quantities of arachidonic acid metabolites produced by a given tumor varied ...
R A, Knazek, C L, Yee, J, Costa
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Conversion of 15-hydroxyeicosatetraenoic acid to 11-hydroxyhexadecatrienoic acid by endothelial cells

Biochemistry, 1988
Cultured endothelial cells take up 15-hydroxyeicosatetraenoic acid (15-HETE), a lipoxygenase product formed from arachidonic acid, and incorporate it into cellular phospholipids and glycerides. Uptake can occur from either the apical or basolateral surface.
X Y, Shen, P H, Figard, T L, Kaduce, A A, Spector   +3 more
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A practical enantioselective synthesis of 12-hydroxyeicosatetraenoic acids

Tetrahedron Letters, 1988
Abstract A practical enantioselective synthesis of 12(R)-HETE has been achieved from readily available starting materials. This process also constitutes a formal synthesis of Leukotriene B 4 .
Stevan W Djurić, Julie M Miyashiro, Thomas D Penning   +2 more
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Transformation and degradation of leukotriene B4, 12-hydroxyeicosatetraenoic acid and 5-hydroxyeicosatetraenoic acid induced by ultraviolet radiation.

Photodermatology, photoimmunology & photomedicine, 1992
To reveal the underlying mechanisms in the therapeutic effectiveness of ultraviolet (UBV)- and psoralen plus UVA phototherapy, the photostability of leukotriene B4 (LTB4), 12-hydroxyeicosatetraenoic acid (12-HETE) and 5-HETE was investigated in the presence and absence of photosensitizers (8-methoxypsoralen and 5-methoxypsoralen).
B, Lehmann, A, Kämpf, J, Barth
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Cerebral arteries can generate 5- and 15-hydroxyeicosatetraenoic acid from arachidonic acid

Canadian Journal of Physiology and Pharmacology, 1990
Products of the lipoxygenase pathway have been implicated in the development of the cerebrovascular spasm that arises after subarachnoid hemorrhage. In particular the hydroperoxyeicosatetranenoic acids (HPETEs), which are unstable and break down rapidly to the corresponding 5-hydroxy acids (HETEs), are vasoconstrictor agents that mimic some aspects of
R, Schulz, S, Jancar, D A, Cook
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Recent developments on the vascular effects of 20-hydroxyeicosatetraenoic acid

Current Opinion in Nephrology and Hypertension, 2016
20-Hydroxyeicosatetraenoic acid (20-HETE) is a potent vasoactive eicosanoid and a key constituent of the microcirculation. Its effects on vascular function are multifaceted and include stimulation of smooth muscle, contractility, migration, and proliferation, as well as endothelial cell dysfunction and inflammation.
Victor, Garcia, Michal L, Schwartzman
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Hydroxyeicosatetraenoic acids (HETEs)

Progress in Lipid Research, 1988
A A, Spector, J A, Gordon, S A, Moore
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[31] 12-Hydroxyeicosatetraenoic acid and related compounds

1981
Publisher Summary This chapter describes the preparation and effects of 12-hydroxyeicosatetraenoic acid. 12- L -Hydroxy-5,8,10,14-eicosatetraenoic acid (12-HETE) is one of the major metabolites of arachidonic acid in many tissues or organs. It is the enzymatic product of a novel lipoxygenase present in platelets, leukocytes, spleen, lung, skin, and ...
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Blockade of Receptor‐Mediated Cyclic GMP Formation by Hydroxyeicosatetraenoic Acid

Journal of Neurochemistry, 1987
AbstractReceptor‐mediated cyclic GMP formation in N1E‐115 murine neuroblastoma cells appears to involve oxidative metabolism of arachidonic acid. Evidence in support of this includes the blockade of this response by lipoxygenase inhibitors, e.g., eicosatetraynoic acid (ETYA) or other metabolic perturbants, e.g., methylene blue.
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