Results 11 to 20 of about 6,850 (177)
Metabolites, 2021 Allergen immunotherapy (AIT) is the only treatment that can change the course of allergic diseases. However, there has not been any research on metabolic reactions in relation to AIT with single or mixed allergens.
Peiyan Zheng +8 more
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Renal 20-hydroxyeicosatetraenoic acid synthesis during pregnancy [PDF]
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2002 We examined whether renal 20-hydroxyeicosatetraenoic acid (20-HETE) synthesis is altered during gestation. Renal microsomal arachidonic acid ω-hydroxylase activity increased by 50 and 48% in rats on days 12 and 19 of gestation, respectively. Renal microvessel 20-HETE synthesis increased by 50 and 82% in rats on days 6 and 12 of gestation, respectively,
Mong-Heng, Wang +3 more
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Journal of Lipid Research, 1999 12-Lipoxygenase and cyclooxygenase 1 are the dominating enzymes that metabolize arachidonic acid in human platelets. In addition to the conversion of arachidonic acid to 12(S)-hydroxyeicosatetraenoic acid, 12-lipoxygenase can also utilize 5(S ...
Marina Dadaian, Par Westlund
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Metabolism of oxygenated derivatives of arachidonic acid by Caco-2 cells.
Journal of Lipid Research, 1992 Monolayers of Caco-2 cells, a human enterocyte cell line, were incubated separately with 3H8-labeled preparations of three different lipid mediators of inflammation: 5-hydroxyeicosatetraenoic acid, 12-hydroxyeicosatetraenoic acid, and leukotriene B4 ...
TE Riehl, J Turk, WF Stenson
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Roles of hydroxyeicosatetraenoic acids in diabetes (HETEs and diabetes)
Biomedicine & Pharmacotherapy, 2022 Hydroxyeicosatetraenoic acids (HETEs) are metabolites of arachidonate acid (AA) oxidized by lipoxygenases or cytochrome P450 enzymes (CYP450). Since lipoxygenases and CYP450 enzymes widely exist in different organs and tissues, HETEs play significant roles in normal physiological and pathophysiological conditions. Mounting evidence has shown that HETEs
Linyue, Dong +3 more
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Metabolism of 15-hydroxyeicosatetraenoic acid by Caco-2 cells.
Journal of Lipid Research, 1990 Monolayers of Caco-2 cells, a human enterocyte cell line, were incubated with [1-14C]15-hydroxyeicosatetraenoic acid (15-HETE), a lipid mediator of inflammation, and [1-14C]arachidonic acid.
TE Riehl, NM Bass, WF Stenson
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Identification of hydroxyeicosatetraenoic acid components of schistosomal hemozoin [PDF]
Biochemical and Biophysical Research Communications, 2007 During the late stages of Schistosoma mansoni infection, adult schistosomes catabolize host erythrocytic hemoglobin. In order to evade the toxic effects of free heme, the blood fluke biomineralizes dimeric heme into an inert crystalline pigment called hemozoin.
Melissa D, Carter +2 more
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Stereospecificity of the products of the fatty acid oxygenases derived from psoriatic scales.
Journal of Lipid Research, 1991 The principal in vivo oxygenase products of arachidonic acid and linoleic acid in psoriatic skin scales are 12-hydroxyeicosatetraenoic acid (R/S ratio = 5.7), 13-hydroxyoctadecadienoic acid (S/R = 1.9), and 9-hydroxyoctadecadienoic acid (R/S = 2.4 ...
AN Baer, PB Costello, FA Green
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Preparation of 20-HETE using multifunctional enzyme type 2-negative Starmerella bombicola[S]
Journal of Lipid Research, 2013 The metabolism of arachidonic acid (ARA) by cytochrome P450 ω/ω-1-hydroxylases leads to the formation of 20-hydroxyeicosatetraenoic acid (20-HETE), which is an important lipid-signaling molecule involved in regulation of vascular tone, angiogenesis, and ...
Inge Van Bogaert +6 more
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20-Hydroxyeicosatetraenoic Acid and Angiotensin [PDF]
Hypertension, 2010 Arachidonic acid metabolites generated by cytochrome P450 (CYP) enzymes are now recognized as contributing importantly to vascular function and blood pressure regulation.1 CYP4A enzymes act as hydroxylases converting arachidonic acid to hydroxyeicosatetraenoic acids (HETEs), with 20-HETE being the major product.
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