Results 41 to 50 of about 6,850 (177)

Simultaneous tissue profiling of eicosanoid and endocannabinoid lipid families in a rat model of osteoarthritis[S]

Journal of Lipid Research, 2014
We describe a novel LC method for the simultaneous and quantitative profiling of 43 oxylipins including eicosanoids, endocannabinoids, and structurally related bioactive lipids with modified acyl groups.
Amy Wong, Devi R. Sagar, Catharine A. Ortori, David A. Kendall, Victoria Chapman, David A. Barrett   +5 more
doaj   +1 more source

Steroidogenic compensation and lipid deficiency with enhanced NAD+ salvage in small‐for‐gestational‐age placenta

The FEBS Journal, EarlyView.
Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo, Lorenza Driul, Vanessa Tolotto, Eros Di Giorgio, Luigi E. Xodo   +4 more
wiley   +1 more source

Race‐based and sex‐based differences in bioactive lipid mediators after myocardial infarction

ESC Heart Failure, 2020
Aims Leucocyte‐directed specialized pro‐resolving mediators (SPMs) are essential for cardiac repair, and their biosynthesis coincides with the expression of pro‐inflammatory mediators; however, the precise quantitation during an acute myocardial ...
Ganesh V. Halade, Vasundhara Kain, Chrisly Dillion, Mark Beasley, Tanja Dudenbostel, Suzanne Oparil, Nita A. Limdi   +6 more
doaj   +1 more source

Identification of a Feed-Forward Loop Between 15(S)-HETE and PGE2 in Human Amnion at Parturition

Journal of Lipid Research, 2022
Human parturition is associated with massive arachidonic acid (AA) mobilization in the amnion, indicating that large amounts of AA-derived eicosanoids are required for parturition. Prostaglandin E2 (PGE2) synthesized from the cyclooxygenase (COX) pathway
Fan Zhang, Kang Sun, Wang-Sheng Wang
doaj   +1 more source

Skin Barrier– and Immune Response–Related Biomarkers of Solar UVR Exposure Comparing Indoor and Outdoor Workers

JID Innovations
Outdoor workers have increased risk of developing keratinocyte cancer due to accumulated skin damage resulting from chronic and excessive exposure to UVR. This study aims to identify potential noninvasive biomarkers to assess chronic UVR exposure.
Florentine L. de Boer, Henk F. van der Molen, Jen-Hung Wang, Ellen Raun, Jorge Pereda, Edwin En-Te Hwu, Ivone Jakasa, Sandrine Dubrac, Thomas Rustemeyer, Sanja Kezic   +9 more
doaj   +1 more source

Arachidonic and linoleic acid derivatives impact oocyte ICSI fertilization--a prospective analysis of follicular fluid and a matched oocyte in a 'one follicle--one retrieved oocyte--one resulting embryo' investigational setting.

PLoS ONE, 2015
ObjectiveTo evaluate human oocyte ability to undergo fertilization and subsequent preimplantation embryonic development in relation to a wide panel of follicular fluid (FF) arachidonic acid derivatives (AAD) and linoleic acid derivatives (LAD) of ...
Przemysław Ciepiela, Tomasz Bączkowski, Arleta Drozd, Anna Kazienko, Ewa Stachowska, Rafał Kurzawa   +5 more
doaj   +1 more source

Dupilumab Dampens Mucosal Type 2 Response During Acetylsalicylic Acid Challenge in N‐ERD Patients

Clinical &Experimental Allergy, Volume 56, Issue 3, Page 227-242, March 2026.
Dupilumab therapy reduced elevated type 2 cytokine responses post‐ASA provocation in N‐ERD patients, independent of ASA tolerance, and revealed novel mechanistic insights by modulating acute type 2 immunity. Transcriptomic analysis showed concurrent downregulation of lipid and peroxisome pathways during ASA challenge in N‐ERD patients after 24 weeks of
Julia Eckl‐Dorna, Christina Morgenstern, Katharina Poglitsch, Tamara Arnoldner, Katharina Gangl, Tina J. Bartosik, Nicholas J. Campion, Aldine Tu, Victoria Stanek, Sven Schneider, Christine Bangert   +10 more
wiley   +1 more source

A Role of the ABCC4 Gene Polymorphism in Airway Inflammation of Asthmatics

Mediators of Inflammation, 2017
The ATP-binding cassette subfamily C member 4 gene encodes a transmembrane protein involved in the export of proinflammatory molecules, including leukotriene, prostaglandin, and sphingosine-1-phosphate across the plasma membrane.
Sailesh Palikhe, Udval Uuganbayar, Hoang Kim Tu Trinh, Ga-Young Ban, Eun-Mi Yang, Hae-Sim Park, Seung-Hyun Kim   +6 more
doaj   +1 more source

Determination of major UDP-glucuronosyltransferase enzymes and their genotypes responsible for 20-HETE glucuronidation[S]

Journal of Lipid Research, 2014
The compound 20-HETE is involved in numerous physiological functions, including blood pressure and platelet aggregation. Glucuronidation of 20-HETE by UDP-glucuronosyltransferases (UGTs) is thought to be a primary pathway of 20-HETE elimination in humans.
Yazun Bashir Jarrar, Eun-Young Cha, Kyung-Ah Seo, Jong-Lyul Ghim, Hyo-Ji Kim, Dong-Hyun Kim, Su-Jun Lee, Jae-Gook Shin   +7 more
doaj   +1 more source

Computational and Experimental Analysis Reveals the Arachidonic Acid Metabolite 20-Hydroxyeicosatetraenoic Acid is a Novel Ligand of the Na/K-ATPase

Translation, 2023
Please view the PDF to see the formatted meeting abstract.  
Dhilhani Faleel
doaj   +1 more source