Results 51 to 60 of about 6,850 (177)

Preventing Atherosclerotic Cardiovascular Disease in Young Male Androgen Abusers

Clinical Cardiology, Volume 49, Issue 2, February 2026.
Androgen abuse is an underrecognized ASCVD risk enhancer in young men. Improved risk assessment—integrating androgen exposure, imaging, and individualized prevention—may help in the management of long‐term cardiovascular risk in this population. ABSTRACT Background Androgen abuse among young men is a prevalent yet under recognized risk factor for ...
Peter Bond, Diederik L. Smit, Tijs Verdegaal, Willem de Ronde   +3 more
wiley   +1 more source

New analogues of 13-hydroxyocatdecadienoic acid and 12-hydroxyeicosatetraenoic acid block human blood platelet aggregation and cyclooxygenase-1 activity

Chemistry Central Journal, 2012
Background Thromboxane A2 is derived from arachidonic acid through the action of cyclooxygenases and thromboxane synthase. It is mainly formed in blood platelets upon activation and plays an important role in aggregation. Aspirin is effective in reducing
Hirz Taghreed, Khalaf Ali, El-Hachem Nehme, Mrad May F, Abdallah Hassan, Créminon Christophe, Grée René, Merhi Raghida Abou, Habib Aïda, Hachem Ali, Hamade Eva   +10 more
doaj   +1 more source

LRP4+ Astrocytes: A Unique Subpopulation Crucial for Blood Vessel Maintenance and Function in the Somatosensory Cortex of Normal and 5xFAD Mice

Glia, Volume 74, Issue 2, February 2026.
Lrp4+ astrocytes, uniquely vessel‐associated and GFAP−, are enriched in the pia. They support laminin‐α5+ basement membrane assembly and regulate vessel diameter and blood flow. They are reduced in 5xFAD brains, and their ablation worsens both vascular and Aβ pathology.
Emily Arzola, Gefei Yu, Lei Xiong, Daehoon Lee, Anika Wu, Shriya Paruchuri, Jasmine Skinner, Minghui Wang, Bin Zhang, Lin Mei, Wen‐Cheng Xiong   +10 more
wiley   +1 more source

Anatomical and Neuronal Distribution of the G‐Coupled Protein Receptor 75 mRNA in the Mouse Central Nervous System

European Journal of Neuroscience, Volume 63, Issue 4, February 2026.
GPR75, a Gαq‐coupled receptor highly expressed in the CNS, shows distinct mRNA localization across multiple neuronal sub populations, including GABAergic, glutamatergic and monoaminergic neurons. Using RNAscope FISH combined with IHC, we mapped GPR75 expression throughout the mouse brain, revealing particularly high levels in the locus coeruleus and ...
Melanie K. Becher, Tessa Knox, Kaela Wilson, Lawrence F. Kromer, Italo Mocchetti   +4 more
wiley   +1 more source

Stabilization and improved activity of arachidonate 11S-lipoxygenase from proteobacterium Myxococcus xanthus

Journal of Lipid Research, 2018
Lipoxygenases (LOXs) catalyze the dioxygenation of PUFAs to produce regio- and stereospecific oxygenated fatty acids. The identification of regio- and stereospecific LOXs is important because their specific products are involved in different ...
Jung-Ung An, Deok-Kun Oh
doaj   +1 more source

Sex‐dependent role of 20‐HETE synthesis in outcome from ischemic stroke in rats

Physiological Reports, Volume 14, Issue 3, February 2026.
Abstract The lipid mediator 20‐HETE is produced by ω‐hydroxylation of arachidonic acid mediated by cytochrome P450 (CYP) enzymes including CYP4A, which has four distinct isoforms in rodents. Several laboratories demonstrated that 20‐HETE synthesis inhibition reduces infarct volume following middle cerebral artery occlusion (MCAO) in male animals. Here,
Rongrong Zhang, Yanrong Shi, Suyi Cao, Raymond C. Koehler, Zeng‐Jin Yang   +4 more
wiley   +1 more source

12‐HETE is an Endogenous Modulator of BLT2 Triggering Vascular Degeneration, Dissection, and Rupture

Advanced Science, Volume 13, Issue 5, 27 January 2026.
In thoracic aortic dissection (TAD), elevated levels of the arachidonic acid metabolite 12‐HETE, produced by macrophage‐specific 12/15‐lipoxygenase (12/15‐LOX), bind to the BLT2 receptor on vascular cells. This activates the NOX‐1/ROS/NF‐κB signaling pathway, leading to IL‐6 release.
Yuyu Li, Jiaqi Yu, Weiyao Chen, Xue Wang, Xin Tan, Jing Cui, Yihao Wang, Xuan Xu, Rui Lin, Zhengkai Wang, Wenxi Jiang, Yongliang Zhong, Jie Du, Yuan Wang   +13 more
wiley   +1 more source

Alterations of Bioactive Lipid Profiles in the Retina Following Traumatic Optic Neuropathy in Mice

Biomolecules
Traumatic optic neuropathy (TON) causes vision loss through compression and contusion, yet there is no consensus on the most effective treatment. Polyunsaturated fatty acid (PUFA)-derived bioactive lipids metabolized by lipoxygenase (LOX), cytochrome ...
Min Young Kim, Nandini Koneru, Gieth Alahdab, Michael Risner, Ahmed S. Ibrahim, Krishna Rao Maddipati, Mohamed Al-Shabrawey   +6 more
doaj   +1 more source

Effect of cholesterol enrichment on 12-hydroxyeicosatetraenoic acid metabolism by mouse peritoneal macrophages

Journal of Lipid Research, 1987
The metabolism of 12-hydroxyeicosatetraenoic acid (12-HETE) was investigated in mouse peritoneal macrophages enriched in cholesterol by incubation with acetylated low density lipoproteins.
S N Mathur, F J Field
doaj   +1 more source

Astrocyte–vascular interplay in Alzheimer's disease pathology: Novel insights into stage‐specific biomarkers and therapeutic targets

Alzheimer's &Dementia, Volume 22, Issue 1, January 2026.
Abstract INTRODUCTION We examined how neurovascular and astrocytic response alter cognition in Alzheimer's disease (AD). METHODS Cognitive scores, biomarkers of AD and astrocytic activation, vascular factors, and brain structure data from 693 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants were analyzed using analysis of covariance ...
Zehu Sheng, Yuhao Chen, Ming Chen, Shuyu Liang, Jingyi Wang, Yingxi Chen, Rengui Li, Boyuan Xia, Kangjinyuan Gou, Siyuan Liu, Alzheimer's Disease Neuroimaging Initiative, Weihua Yu, Yang Lü   +12 more
wiley   +1 more source