Results 61 to 70 of about 6,850 (177)

Structural Impact of 4‐Hydroxynonenal Modification on Human Cytochrome CYP4F11

ChemMedChem, Volume 21, Issue 2, January 2026.
Protein lipoxidation by 4‐hydroxynonenal induces conformational and stability changes in human CYP4F11, as revealed by DSC, FTIR, and Raman spectroscopy, with potential consequences for enzymatic function. Posttranslational modifications of human enzymes play a crucial role in disease development. 4‐hydroxynonenal (4‐HNE), a lipid peroxidation product,
Olena Gnatyuk, Oleksii Skorokhod, Alessandro Damin, Mykhailo Chaika, Fateme Naeimaeirouhani, Loris Pica, Anita Tomatis, Aleksandra Smorygo, Taras Voitsitskyi, Gianluca Catucci, Galyna Dovbeshko, Gianfranco Gilardi   +11 more
wiley   +1 more source

Oxylipins in Aqueous Humor of Primary Open-Angle Glaucoma Patients

Biomolecules
Purpose: Investigate the oxylipin profiles in the aqueous humor of primary open-angle glaucoma (POAG) patients. Methods: Aqueous humor samples were collected from 17 POAG patients and 15 cataract subjects and subjected to a liquid chromatography/mass ...
Jianming Xu, Kewen Zhou, Changzhen Fu, Chong-Bo Chen, Yaru Sun, Xin Wen, Luxi Yang, Tsz-Kin Ng, Qingping Liu, Mingzhi Zhang   +9 more
doaj   +1 more source

Lipoxygenase Activity Accelerates Programmed Spore Germination in Aspergillus fumigatus

Frontiers in Microbiology, 2017
The opportunistic human pathogen Aspergillus fumigatus initiates invasive growth through a programmed germination process that progresses from dormant spore to swollen spore (SS) to germling (GL) and ultimately invasive hyphal growth.
Gregory J. Fischer, William Bacon, Jun Yang, Jonathan M. Palmer, Taylor Dagenais, Bruce D. Hammock, Nancy P. Keller   +6 more
doaj   +1 more source

Dihydroquercetin Attenuates Silica‐Induced Pulmonary Fibrosis by Modulating the Gut Microbiota and the Serum Metabolites in Mice

Food Science &Nutrition, Volume 14, Issue 1, January 2026.
(1) DHQ can attenuate silica‐induced inflammation and pulmonary fibrosis in the C57BL/6 mice. (2) The beneficial effects of DHQ were primarily attributed to the alteration of gut microbiota (particularly Muribaculaceae and Lactobacillus) mediated by serum metabolites.
Zunqiong Ke, Lishu Lin, Yunhong Long, Wenhui Zhang, Jianmin Guo, Leyong Yuan   +5 more
wiley   +1 more source

Regulation of Insulin Secretion Through Long‐Chain Fatty Acid Receptors

iNew Medicine, Volume 2, Issue 1, March 2026.
Stefan Offermanns
wiley   +1 more source

Hypomorphic ATP11c is a novel regulator of decreased efficacy of transfused red blood cells in humans and mice

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract Chronic red blood cell (RBC) transfusion sustains patients with diverse hematologic disorders, but repeated transfusion leads to iron overload and alloimmunization. Reducing transfusion burden requires identifying donor units that circulate more effectively after storage, yet determinants of this variability remain incompletely defined.
James C. Zimring, Ariel M. Hay, Monika Dzieciatkowska, Daniel Stephenson, Zachary B. Haiman, Steven Kleinman, Philip J. Norris, Michael P. Busch, Nareg Roubinian, Elisa Fermo, Paola Bianchi, Gregory R. Keele, Grier P. Page, Angelo D'Alessandro   +13 more
wiley   +1 more source

Overexpression of 12/15-Lipoxygenase, an Ortholog of Human 15-Lipoxygenase-1, in the Prostate Tumors of TRAMP Mice

Neoplasia: An International Journal for Oncology Research, 2004
Changes in the expression and activity of lipidmetabolizing enzymes, including the linoleic acid (LA) -metabolizing enzyme 15-lipoxygenase-1 (15-LO-1), may play a role in the development and progression of human prostate carcinoma (PCa). We reported that
Uddhav P. Kelavkar, Wayne Glasgow, Sandra J. Olson, Barbara A. Foster, Scott B. Shappell   +4 more
doaj   +1 more source

Association of Ticagrelor Metabolic SNPs With Adverse Drug Reactions in Patients With Acute Coronary Syndrome

Clinical Cardiology, Volume 48, Issue 12, December 2025.
The CYP3A5 rs776746 CC genotype is a strong biomarker for ticagrelor‐induced dyspnea, conferring a 2.3‐fold higher risk. Genotype‐guided antiplatelet therapy may mitigate this adverse reaction, enabling personalized treatment for ACS patients. ABSTRACT Background Dual antiplatelet therapy with aspirin and a P2Y₁₂ inhibitor is standard for patients with
Yanming Zhang, Gaoxiu Yu, Cong Wang, Jingwen Song, Junmei Liu, Feng Chen   +5 more
wiley   +1 more source

Profile of Arachidonic Acid-Derived Inflammatory Markers and Its Modulation by Nitro-Oleic Acid in an Inherited Model of Amyotrophic Lateral Sclerosis

Frontiers in Molecular Neuroscience, 2018
The lack of current treatments for amyotrophic lateral sclerosis (ALS) highlights the need of a comprehensive understanding of the biological mechanisms of the disease.
Andrés Trostchansky, Andrés Trostchansky, Mauricio Mastrogiovanni, Mauricio Mastrogiovanni, Ernesto Miquel, Ernesto Miquel, Sebastián Rodríguez-Bottero, Sebastián Rodríguez-Bottero, Laura Martínez-Palma, Laura Martínez-Palma, Patricia Cassina, Patricia Cassina, Homero Rubbo, Homero Rubbo   +13 more
doaj   +1 more source

Resolution of inflammation in pulmonary arterial hypertension, the influence of sex—An IUPHAR immunopharmacology committee review

British Journal of Pharmacology, Volume 182, Issue 23, Page 5706-5733, December 2025.
Pulmonary arterial hypertension (PAH) is a progressive and life‐threatening disease with limited treatment options. Sex differences are apparent in PAH, specifically in the pathophysiology, prognoses and pharmacological responses of patients. Inflammation and its resolution, which often differ between sexes, are dysregulated in chronic inflammatory ...
Chloe Landy, Miles J. De Blasio, Owen L. Woodman, Pasquale Maffia, Hong Yong Peh, Cheng Xue Qin   +5 more
wiley   +1 more source