Mitochondrial metabolism of 12- and 15-hydroxyeicosatetraenoic acids.
Journal of Lipid Research, 1994 We have previously demonstrated that peroxisomal-deficient human skin fibroblasts and mutant Chinese hamster ovary cells do not convert 12- and 15-hydroxyeicosatetraenoic acids (HETEs) to chain-shortened, polar metabolites, suggesting that peroxisomes ...
J.A. Gordon +3 more
doaj +5 more sources
Heart failure-induced activation of phospholipase iPLA2γ generates hydroxyeicosatetraenoic acids opening the mitochondrial permeability transition pore. [PDF]
J Biol Chem, 2018 Congestive heart failure typically arises from cardiac myocyte necrosis/apoptosis, associated with the pathological opening of the mitochondrial permeability transition pore (mPTP).
Moon SH +8 more
europepmc +4 more sources
Arachidonic acid-derived hydroxyeicosatetraenoic acids are positively associated with colon polyps in adult males: a cross-sectional study [PDF]
Scientific Reports, 2019 Oxylipids are potent lipid mediators associated with inflammation-induced colon carcinomas and colon tumor survival. Therefore, oxylipid profiles may be useful as novel biomarkers of colon polyp presence.
C. Austin Pickens +3 more
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Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid. [PDF]
Biochim Biophys Acta, 2015 Powell WS, Rokach J.
europepmc +4 more sources
Increased Epoxyeicosatrienoic Acids and Hydroxyeicosatetraenoic Acids After Treatment of Iodide Intake Adjustment and 1,25-Dihydroxy-Vitamin D3 Supplementation in High Iodide Intake–Induced Hypothyroid Offspring Rats [PDF]
Frontiers in Physiology, 2021 Aim: This study aimed to investigate the potential role of fatty acids in high iodide intake–induced hypothyroidism and its complications and also in the intervention of iodide intake adjustment and 1,25-dihydroxy-vitamin D3 [1,25(OH)2D3] supplementation.
Qing Liu +3 more
doaj +2 more sources
Effects of arachidonic acid on the concentration of hydroxyeicosatetraenoic acids in culture media of mesenchymal stromal cells differentiating into adipocytes or osteoblasts. [PDF]
Genes Nutr, 2014 Casado-Díaz A +5 more
europepmc +4 more sources
Roles of hydroxyeicosatetraenoic acids in diabetes (HETEs and diabetes).
Biomedicine & Pharmacotherapy, 2022 Hydroxyeicosatetraenoic acids (HETEs) are metabolites of arachidonate acid (AA) oxidized by lipoxygenases or cytochrome P450 enzymes (CYP450). Since lipoxygenases and CYP450 enzymes widely exist in different organs and tissues, HETEs play significant ...
Lin Dong +3 more
semanticscholar +3 more sources
Journal of Lipid Research, 1999 12-Lipoxygenase and cyclooxygenase 1 are the dominating enzymes that metabolize arachidonic acid in human platelets. In addition to the conversion of arachidonic acid to 12(S)-hydroxyeicosatetraenoic acid, 12-lipoxygenase can also utilize 5(S ...
Marina Dadaian, Par Westlund
doaj +2 more sources
Journal of Lipid Research, 2006 Eicosanoids participate in the regulation of cellular proliferation. Thus, we observed that prostaglandin E2 interaction with membrane receptors is involved in the control of 3T6 fibroblast growth induced by serum.
Diana Nieves, Juan José Moreno
doaj +2 more sources
Epoxyeicosatrienoic Acids and 20-Hydroxyeicosatetraenoic Acid on Endothelial and Vascular Function. [PDF]
Advances in Pharmacology, 2016 Endothelial and vascular smooth cells generate cytochrome P450 (CYP) arachidonic acid metabolites that can impact endothelial cell function and vascular homeostasis. The objective of this review is to focus on the physiology and pharmacology of endothelial CYP metabolites.
J. Imig
semanticscholar +3 more sources