Results 21 to 30 of about 5,905,176 (286)

Renal 20-hydroxyeicosatetraenoic acid synthesis during pregnancy [PDF]

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2002
We examined whether renal 20-hydroxyeicosatetraenoic acid (20-HETE) synthesis is altered during gestation. Renal microsomal arachidonic acid ω-hydroxylase activity increased by 50 and 48% in rats on days 12 and 19 of gestation, respectively. Renal microvessel 20-HETE synthesis increased by 50 and 82% in rats on days 6 and 12 of gestation, respectively,
Mong-Heng, Wang, Barbara A, Zand, Alberto, Nasjletti, Michal, Laniado-Schwartzman   +3 more
openaire   +2 more sources

Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors

Frontiers in Pharmacology, 2020
Oxylipins derived from the oxidation of polyunsaturated fatty acids (PUFAs) act as important paracrine and autocrine signaling molecules. A subclass of oxylipins, the eicosanoids, have a broad range of physiological outcomes in inflammation, the immune ...
Eric A. Evangelista, Christi W. Cho, Theresa Aliwarga, Rheem A. Totah   +3 more
doaj   +1 more source

Pleiotropic Functions of Cytochrome P450 Monooxygenase-Derived Eicosanoids in Cancer

Frontiers in Pharmacology, 2020
Eicosanoids are a class of functionally bioactive lipid mediators derived from the metabolism of long-chain polyunsaturated fatty acids (PUFAs) mediated by multiple enzymes of three main branches, including cyclooxygenases (COXs), lipoxygenases (LOXs ...
Ying Luo, Jun-Yan Liu
doaj   +1 more source

INTERCEPT Pathogen Reduction in Platelet Concentrates, in Contrast to Gamma Irradiation, Induces the Formation of trans-Arachidonic Acids and Affects Eicosanoid Release during Storage

Biomolecules, 2022
Pathogen inactivation techniques for blood products have been implemented to optimize clinically safe blood components supply. The INTERCEPT system uses amotosalen together with ultraviolet light wavelength A (UVA) irradiation.
Gerda C. Leitner, Gerhard Hagn, Laura Niederstaetter, Andrea Bileck, Kerstin Plessl-Walder, Michaela Horvath, Vera Kolovratova, Andreas Tanzmann, Alexander Tolios, Werner Rabitsch, Philipp Wohlfarth, Christopher Gerner   +11 more
doaj   +1 more source

Metabolism of oxygenated derivatives of arachidonic acid by Caco-2 cells.

Journal of Lipid Research, 1992
Monolayers of Caco-2 cells, a human enterocyte cell line, were incubated separately with 3H8-labeled preparations of three different lipid mediators of inflammation: 5-hydroxyeicosatetraenoic acid, 12-hydroxyeicosatetraenoic acid, and leukotriene B4 ...
TE Riehl, J Turk, WF Stenson
doaj   +1 more source

Metabolism of 15-hydroxyeicosatetraenoic acid by Caco-2 cells.

Journal of Lipid Research, 1990
Monolayers of Caco-2 cells, a human enterocyte cell line, were incubated with [1-14C]15-hydroxyeicosatetraenoic acid (15-HETE), a lipid mediator of inflammation, and [1-14C]arachidonic acid.
TE Riehl, NM Bass, WF Stenson
doaj   +1 more source

Identification of hydroxyeicosatetraenoic acid components of schistosomal hemozoin [PDF]

Biochemical and Biophysical Research Communications, 2007
During the late stages of Schistosoma mansoni infection, adult schistosomes catabolize host erythrocytic hemoglobin. In order to evade the toxic effects of free heme, the blood fluke biomineralizes dimeric heme into an inert crystalline pigment called hemozoin.
Melissa D, Carter, S, Reese Harry, David W, Wright   +2 more
openaire   +2 more sources

Analysis of HETEs in human whole blood by chiral UHPLC-ECAPCI/HRMS

Journal of Lipid Research, 2018
The biosynthesis of eicosanoids occurs enzymatically via lipoxygenases, cyclooxygenases, and cytochrome P450, or through nonenzymatic free radical reactions. The enzymatic routes are highly enantiospecific.
Liudmila L. Mazaleuskaya, Ashkan Salamatipour, Dimitra Sarantopoulou, Liwei Weng, Garret A. FitzGerald, Ian A. Blair, Clementina Mesaros   +6 more
doaj   +1 more source

Prophylactic inhibition of soluble epoxide hydrolase delays onset of nephritis and ameliorates kidney damage in NZB/W F1 mice [PDF]

, 2019
Epoxy-fatty-acids (EpFAs), cytochrome P450 dependent arachidonic acid derivatives, have been suggested to have anti-inflammatory properties, though their effects on autoimmune diseases like systemic lupus erythematosus (SLE) have yet to be investigated ...
Dragun, Duska, Enghard, Philipp, Gollasch, Maik, Hammock, Bruce D., Klocke, Jan, Riemekasten, Gabriela, Rudolph, Birgit, Schunck, Wolf-Hagen, Ulu, Arzu, Wu, Kaiyin   +9 more
core   +2 more sources

A high throughput screen identifies potent and selective inhibitors to human epithelial 15-lipoxygenase-2. [PDF]

PLoS ONE, 2014
Lipoxygenase (LOX) enzymes catalyze the hydroperoxidation of arachidonic acid and other polyunsaturated fatty acids to hydroxyeicosatetraenoic acids with varying positional specificity to yield important biological signaling molecules.
J Brian Jameson, Auric Kantz, Lena Schultz, Chakrapani Kalyanaraman, Matthew P Jacobson, David J Maloney, Ajit Jadhav, Anton Simeonov, Theodore R Holman   +8 more
doaj   +1 more source