Results 191 to 200 of about 97,747 (236)

Direct hydroxylation of benzene to phenol using hydrogen peroxide catalyzed by nickel complexes supported by pyridylalkylamine ligands.

Journal of the American Chemical Society, 2015
Selective hydroxylation of benzene to phenol has been achieved using H2O2 in the presence of a catalytic amount of the nickel complex [Ni(II)(tepa)](2+) (2) (tepa = tris[2-(pyridin-2-yl)ethyl]amine) at 60 °C.
Y. Morimoto, Shuji Bunno, N. Fujieda, H. Sugimoto, S. Itoh   +4 more
semanticscholar   +1 more source

N-heterocyclic carbene-catalyzed radical reactions for highly enantioselective β-hydroxylation of enals.

Journal of the American Chemical Society, 2015
An N-heterocyclic carbene-catalyzed β-hydroxylation of enals is developed. The reaction goes through a pathway involving multiple radical intermediates, as supported by experimental observations.
Yuexia Zhang, Yu Du, Zhijian Huang, Jianfeng Xu, Xingxing Wu, YuHuang Wang, Ming Wang, Song Yang, R. Webster, Y. Chi   +9 more
semanticscholar   +1 more source

Drug metabolism by cytochrome p450 enzymes: what distinguishes the pathways leading to substrate hydroxylation over desaturation?

Chemistry, 2015
Cytochrome P450 enzymes are highly versatile biological catalysts in our body that react with a broad range of substrates. Key functions in the liver include the metabolism of drugs and xenobiotics.
Li Ji, Abayomi S Faponle, M. Quesne, Mala A. Sainna, Jing Zhang, Alicja Franke, Devesh Kumar, R. van Eldik, Weiping Liu, S. D. de Visser   +9 more
semanticscholar   +1 more source

Regioselective hydroxylation of steroid hormones by human cytochromes P450

Drug metabolism reviews (Softcover ed.), 2015
This article reviews in vitro metabolic activities [including Michaelis constants (Km), maximal velocities (Vmax) and Vmax/Km] and drug–steroid interactions [such as induction and cooperativity (activation)] of cytochromes P450 (P450 or CYP) in human ...
T. Niwa, N. Murayama, Yurie Imagawa, H. Yamazaki   +3 more
semanticscholar   +1 more source

Hydroxylation of Alkylbenzenes

Journal of the Fuel Society of Japan, 1956
ベンゼンをプロピレン・ブチレンでアルキル化して得られるキューメン, p-ジイソプロピルペンゼ, 第2級ブチルベンゼン, p-ジ-第2級ブチルベンゼンのハイドロキシル化をナフテン酸コバルト触媒を用い, 80℃ 附近の低温度で加圧酸化すると, キューメン, P-ジイソプロピルベンゼンのようにイソプロピルをもつているものは容易にハイドロキシル化され, それに相当するアルコールを生成するが, 第2級ブチル基を有する第2級ブチルベンゼン, p-ジー第2級ブチルベンゼンはアルコールよりもケトンを生成し易い。このアルコールの生成はハイドロパーオキサイドを中間体として進むものと思われ, キューメン, p-ジイソプロピルベンゼンのハイドロパーオキサイドは容易にそれに相当するアルコールに変化した。
Takaaki Arakawa, Shigeru Tsutsumi, Yoshinobu Odaira, Wasaburo Kawai   +3 more
openaire   +2 more sources

Detection of Hydroxyl Radicals by -Phenylalanine Hydroxylation: A Specific Assay for Hydroxyl Radical Generation in Biological Systems

Analytical Biochemistry, 2001
Hydroxylation of l-phenylalanine (Phe) by hydroxyl radical (*OH) yields 4-, 3-, and 2-hydroxyl-Phe (para-, meta-, and ortho-tyrosine, respectively). Phe derivative measurements have been employed to detect *OH formation in cells and tissues, however, the specificity of this assay is limited since Phe derivatives also arise from intracellular Phe ...
Jay L. Zweier, Ruggero Rossi, Giuseppe Ambrosio, Yong Xia, Nazareno Paolocci, Nazareno Paolocci, Roberto Biondi   +6 more
openaire   +3 more sources

Ligand-Promoted Pd-Catalyzed Oxime Ether Directed C–H Hydroxylation of Arenes

, 2015
An efficient Pd-catalyzed oxime ether directed ortho C–H hydroxylation of arenes under neutral conditions has been developed. The efficiency of this hydroxylation is significantly improved by a ligand.
Yu-Feng Liang, Xiaoyang Wang, Yizhi Yuan, Yu-Feng Liang, Xinyao Li, N. Jiao   +5 more
semanticscholar   +1 more source

Hydroxylation of Proline in Vitro

Nature, 1959
WHILE carrying out a study of hydroxyproline synthesis in biological media, by hydroxylation of proline or peptides containing proline, we have also investigated the possibility of hydroxylation of pyrrolidine ring in vitro. We commenced our study by ascertaining1,2,3 whether or not cortisone inhibited the formation of free hydroxyproline in animal ...
J Hurych, M Chvapil
openaire   +3 more sources

Microbial hydroxylation of acetylaminosteroids

Steroids, 1998
An investigation of the microbial biotransformation of a range of 3 beta-, 17 beta-, and 20-acetylamino C18 to C21 steroids by microorganisms known to hydroxylate conventional steroids has been undertaken, using Aspergillus ochraceus, Bacillus megaterium, Curvularia lunata, and Rhizoputus arrhizus. A. ochraceus and B.
Herbert L. Holland, Gingipalli Lakshmaiah, Peter L. Ruddock   +2 more
openaire   +3 more sources

Activation of Wild-Type Cytochrome P450BM3 by the Next Generation of Decoy Molecules: Enhanced Hydroxylation of Gaseous Alkanes and Crystallographic Evidence

, 2015
The direct hydroxylation of alkanes under mild conditions is a key issue in catalytic chemistry that addresses an increasing number of industrial and economic requirements. Cytochrome P450s are monooxygenases that are capable of oxidizing less reactive C–
Zhiqi Cong, O. Shoji, C. Kasai, Norifumi Kawakami, H. Sugimoto, Y. Shiro, Y. Watanabe   +6 more
semanticscholar   +1 more source