The Biochemical Basis of Hydroxymethylglutaryl-CoA Reductase Inhibitors as Neuroprotective Agents in Aneurysmal Subarachnoid Hemorrhage [PDF]
Pharmaceuticals (Basel), 2010 Aneurysmal subarachnoid hemorrhage (SAH) has the highest morbidity and mortality rates of all types of stroke. Many aneurysmal SAH patients continue to suffer from significant neurological morbidity and mortality directly related to delayed cerebral ...
George Kwok Chu Wong, Wai Sang Poon
europepmc +4 more sources
Improvement of clinical outcomes in patients undergoing peritoneal dialysis using hydroxymethylglutaryl-CoA reductase inhibitors: A systematic review and meta-analysis. [PDF]
J Chin Med Assoc, 2023 Background: It is unclear whether hydroxymethylglutaryl-CoA reductase inhibitor (statin) therapy decreases the risk of mortality and cardiovascular disease (CVD) in patients undergoing peritoneal dialysis (PD). Methods: We performed a literature search of PubMed, Cochrane Library ...
Lee DY +5 more
europepmc +3 more sources
Role of Blood Lipid Levels and Lipid-Lowering Therapy in Stroke Patients with Different Levels of Cerebral Artery Diseases: Reconsidering Recent Stroke Guidelines [PDF]
Journal of Stroke, 2021 Hyperlipidemia is an important risk factor for ischemic stroke; the Stroke Prevention by Aggressive Reduction in Cholesterol Level and Treat Stroke to Target studies have shown that statins are beneficial for patients with stroke and that a low target ...
Jong S. Kim
doaj +1 more source
A hydroxymethylglutaryl-CoA reductase inhibitor synthesized by yeasts [PDF]
FEMS Microbiology Letters, 1995 Screening of different yeast species showed that they are able to synthesize hydroxymethylglutaryl-CoA (HMGCoA) reductase inhibitors. Crude methanol extracts and the purified inhibitors from Pichia labacensis and Candida cariosilignicola were tested for their biological activity on the solubilized microsomal HMGCoA reductase from Chinese hamster ovary ...
N, Gunde-Cimerman +2 more
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Early efficacy and safety of statin therapy in Korean patients with hypercholesterolemia: Daegu and Gyeongbuk Statin Registry [PDF]
The Korean Journal of Internal Medicine, 2020 Background/Aims To date, prospective data are limited on efficacy and safety profiles of statin therapy in Korean hypercholesterolemic patients. Hence, the aim of this study was to evaluate the practice patterns of statin therapy and its efficacy and ...
Han Joon Bae +11 more
doaj +1 more source
Effect of atorvastatin on systolic and diastolic function in patients with heart failure with reduced ejection fraction (HFrEF) [PDF]
Medicinski Glasnik, 2021 Aim To investigate the benefit of high-dose lipophilic statin therapy on cardiac remodelling, function and progression of heart failure (HF) in patients with ischemic heart disease.
Faris Zvizdić +4 more
doaj +1 more source
Should all patients with psoriasis receive statins? Analysis according to different strategies, [PDF]
Anais Brasileiros de Dermatologia, 2020 Background: Different strategies have been proposed for the cardiovascular risk management of patients with psoriasis. Objective: To estimate the cardiovascular risk and evaluate two cardiovascular prevention strategies in patients with psoriasis ...
Walter Masson +3 more
doaj +1 more source
Recent updates in dyslipidemia management: perspectives in stroke-specific situation [PDF]
Precision and Future Medicine, 2020 Managing dyslipidemia in stroke is essential. During the past several decades, monumental changes in dyslipidemia management have occurred, resulting in improvement in outcomes of patients with cardiovascular disease (CVD).
Woo-Keun Seo +3 more
doaj +1 more source
Beneficial Effects of Statins on Seizures Independent of Their Lipid-Lowering Effect: A Narrative Review [PDF]
Iranian Journal of Medical Sciences, 2023 Among the many types of central nervous system (CNS) disorders, seizures and epilepsy severely affect the quality of life and routine daily activity of the sufferers.
Arash Amanlou +4 more
doaj +1 more source
Molecular Dynamic Simulation of Hydroxymethylglutaryl-CoA Reductase Inhibitors from Gnetum gnemon L. Seed Extract [PDF]
Pharmacognosy Journal, 2018 Objective: Gnetum gnemon L. (melinjo) seed extract contained trans-resveratrol which has been shown to inhibit hydroxymethylglutaryl-CoA (HMG-CoA) reductase. Therefore it has a potent activity for lowering blood cholesterol. This study was carried out to determine the molecular dynamics simulation of HMG-CoA reductase inhibitors from Gnetum gnemon L ...
Artha, Yuditya +3 more
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