Results 61 to 70 of about 1,976 (187)

In Silico Structural Analysis of Human β‐Glucuronidase for Antibody–Drug Conjugates Optimization

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 3, Page 838-852, March 2026.
ABSTRACT Human β‐glucuronidase (HGUSB), a key lysosomal glycosyl hydrolase for the degradation pathway of glycosaminoglycans (GAGs), plays a crucial role in cell proliferation and inflammation, making it a promising target for novel therapeutic strategies including antibody‐drug conjugates (ADCs) with β‐glucuronic linkers.
Giorgia Canini, Simona Saporiti, Crescenzo Coppa, Mara Rossi, Fabio Centola, Alessandro Arcovito   +5 more
wiley   +1 more source

Hydroxyapatite dissolution kinetics: The effects of molecular configurations of six carboxylic acids

Soil Science Society of America Journal, Volume 90, Issue 2, March/April 2026.
Abstract Phosphorus (P) availability in calcareous soils is limited by the low solubility of calcium phosphate minerals, such as hydroxyapatite (HAP). Carboxylic acid‐promoted dissolution of HAP is well‐known. However, it is not clearly understood how the composition and orientation of functional groups (e.g., carboxyl and β‐hydroxyl group) in ...
Yaniv Freiberg, Yuji Arai
wiley   +1 more source

Chelators in Iron and Copper Toxicity [PDF]

Purpose of Review Chelation therapy is used for diseases causing an imbalance of iron levels (for example haemochromatosis and thalassaemia) or copper levels (for example Menkes’ and Wilson’s diseases).
A Hartwig, A Kattamis, A Miyashiro, AC Dlouhy, AV Hoffbrand, B Gupta, BE Holbein, BE Kim, BM Olabinri, C Thephinlap, CG Roussaeux, CL Alden, CW Ritchie, DJ Kosman, DM Seely, DS Kalinowski, DW Cox, ED Rosenstein, G Lewis, GE Cartwright, GJ Brewer, HV Aposian, IS MacPherson, J Aaseth, J Aaseth, JH Menkes, JM Walshe, JM Walshe, K Aayush, K Brzóska, K Grasedyck, K Jomova, KA Winship, L Alan, L Lannfelt, M Nairz, MD Cappellini, MG Thompson, ML Schilsky, P Das, P Delangle, PJ Crouch, PJ Giardina, RL Anderson, RM Robins-Browne, RR Crichton, S Srichairatanakool, S Waldvogel-Abramowskia, SJS Flora, SK Das, SR Bareggi, T Umemura, TA Rouault, TD Rae, TP Kennedy, U Merle, V Laufberger, V Oliveri, Y Hiasa   +58 more
core   +1 more source

Additives for Aluminum‐Air Batteries: A Review

Small, Volume 22, Issue 16, 17 March 2026.
The role of electrolyte additives in Al–air batteries is investigated by focusing on their capacity to moderate Al corrosion rates, inhibit self‐discharge, and prevent surface barrier formation. Additives present in organic, inorganic, and hybrid categories, which regulate the Al–electrolyte interface by forming protective films on the Al surface ...
Hajar Mahmoudi, Asrar Alam, Patrick Theato, Maria Felicia Gaele, Pasquale Gargiulo, Huijing Li, Tonia Mariarosaria Di Palma   +6 more
wiley   +1 more source

The Rhus chinensis Genome Provides Insights Into Tannin, Flavonoid Biosynthesis, and Glandular Trichome Development

Plant Biotechnology Journal, Volume 24, Issue 3, Page 988-1013, March 2026.
ABSTRACT The “salt tree”, Rhus chinensis, holds significant economic and medicinal value due to its ability to produce Galla chinensis (Chinese gall/gallnut), a plant‐derived medicinal material used in both traditional Chinese and modern medicine that is rich in tannins and flavonoids. It is also renowned for its remarkable stress tolerance.
Zhaogeng Lu, Helin Zou, Jiawen Cui, Tongfei Wang, Lingyu Ma, Shixiong Ren, Yiwei Cao, Xi Zhang, Zixi Chen, Hongyan Bao, Ling Zhu, Yaning Cui, Ruili Li, Xiuyan Yang, Qikun Zhang, Zhili Wang, Wangxiang Zhang, Li Wang, Jinxing Lin, Biao Jin   +19 more
wiley   +1 more source

Speciation of metal complexes of medicinal interest: relationship between solution equilibria and pharmaceutical properties [PDF]

, 2018
Biospeciation of essential and toxic metal ions, metal complexes with biological or medicinal activity are discussed in the paper in order to emphasize the importance of the distribution of metal ions in biological milieu.
Dömötör, Orsolya, Enyedy, Éva Anna, Jakusch, Tamás, Kiss, Tamás   +3 more
core   +2 more sources

Ir(III) Complexes Convert Cold to Hot Tumors via Ferroptosis/Necroptosis‐Driven Immunogenic Cell Death and Photosensitized CD47 Downregulation

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Red‐light‐activated Ir1 overcomes hypoxia tolerance and adapts to the immunosuppressive tumor microenvironment, converting immunologically cold tumors into inflamed hot microenvironments. This conversion is driven by synergistic induction of immunogenic cell death through coordinated ferroptosis‐necroptosis pathways and spatiotemporally controlled ...
Long‐Bo Yu, Peng Wang, Qing‐Hua Shen, Qi‐Xin Guan, Zhi‐Yuan Li, Ying‐Ying Han, Xin‐Yi Zhang, Qing‐Yuan Hu, Cai‐Ping Tan   +8 more
wiley   +1 more source

Advances in LDHs for corrosion-resistant protection of Mg and Al alloys: A review

Journal of Magnesium and Alloys
Layered double hydroxides (LDHs) as coatings attract much attention in corrosion and protection of light metals due to their interesting properties such as in-situ synthesis, unique layer-stacking structure, tunable composition, and good biocompatibility
Lin Wang, Fen Zhang, Zuo-Jun Jiao, Lan-Yue Cui, Yuan-Ding Huang, Shuo-Qi Li, Cheng-Bao Liu, Rong-Chang Zeng   +7 more
doaj   +1 more source

Fasudil attenuates aggregation of α-synuclein in models of Parkinson’s disease [PDF]

, 2016
Parkinson's disease (PD) is the most common neurodegenerative movement disorder, yet disease-modifying treatments do not currently exist. Rho-associated protein kinase (ROCK) was recently described as a novel neuroprotective target in PD.
Hagen Walle, Jan C. Koch, Katrin Eckermann, Lars Tatenhorst, Lars Tönges, Luis Fonseca-Ornelas, Markus Zweckstetter, Mathias Bähr, Paul Lingor, Stefan Becker, Tiago F. Outeiro, Tomás Lopes da Fonseca, Vivian Dambeck   +12 more
core   +3 more sources

Engineering Spontaneous Orientation Polarization in Blends of Polar Organic Semiconductors

Advanced Optical Materials, Volume 14, Issue 2, 14 January 2026.
Spontaneous orientation polarization (SOP) in organic semiconductor thin films can be modulated through molecular blending. A nonpolar dopant disrupts anti‐parallel dipole alignment in a polar host, promoting enhanced dipole orientation. Meanwhile, polar‐polar blends can retain their original dipole alignment, resulting in a linear GSP slope trend ...
Siliang He, Abhinav Kapur, Evgeny Pakhomenko, Ryker Rofshus, Russell J. Holmes   +4 more
wiley   +1 more source