Results 61 to 70 of about 6,933 (234)

In Silico Structural Analysis of Human β‐Glucuronidase for Antibody–Drug Conjugates Optimization

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 3, Page 838-852, March 2026.
ABSTRACT Human β‐glucuronidase (HGUSB), a key lysosomal glycosyl hydrolase for the degradation pathway of glycosaminoglycans (GAGs), plays a crucial role in cell proliferation and inflammation, making it a promising target for novel therapeutic strategies including antibody‐drug conjugates (ADCs) with β‐glucuronic linkers.
Giorgia Canini, Simona Saporiti, Crescenzo Coppa, Mara Rossi, Fabio Centola, Alessandro Arcovito   +5 more
wiley   +1 more source

Chelators in Iron and Copper Toxicity [PDF]

Purpose of Review Chelation therapy is used for diseases causing an imbalance of iron levels (for example haemochromatosis and thalassaemia) or copper levels (for example Menkes’ and Wilson’s diseases).
A Hartwig, A Kattamis, A Miyashiro, AC Dlouhy, AV Hoffbrand, B Gupta, BE Holbein, BE Kim, BM Olabinri, C Thephinlap, CG Roussaeux, CL Alden, CW Ritchie, DJ Kosman, DM Seely, DS Kalinowski, DW Cox, ED Rosenstein, G Lewis, GE Cartwright, GJ Brewer, HV Aposian, IS MacPherson, J Aaseth, J Aaseth, JH Menkes, JM Walshe, JM Walshe, K Aayush, K Brzóska, K Grasedyck, K Jomova, KA Winship, L Alan, L Lannfelt, M Nairz, MD Cappellini, MG Thompson, ML Schilsky, P Das, P Delangle, PJ Crouch, PJ Giardina, RL Anderson, RM Robins-Browne, RR Crichton, S Srichairatanakool, S Waldvogel-Abramowskia, SJS Flora, SK Das, SR Bareggi, T Umemura, TA Rouault, TD Rae, TP Kennedy, U Merle, V Laufberger, V Oliveri, Y Hiasa   +58 more
core   +1 more source

Treatment strategies in Alzheimer’s disease: a review with focus on selenium supplementation [PDF]

, 2016
Alzheimers disease (AD) is a neurodegenerative disorder presenting one of the biggest healthcare challenges in developed countries. No effective treatment exists.
Geir Bjørklund, Jan Aaseth, Jan Alexander, Knut Hestad, Per M. Roos, Petr Dusek, Urban Alehagen   +6 more
core   +2 more sources

Engineering Spontaneous Orientation Polarization in Blends of Polar Organic Semiconductors

Advanced Optical Materials, Volume 14, Issue 2, 14 January 2026.
Spontaneous orientation polarization (SOP) in organic semiconductor thin films can be modulated through molecular blending. A nonpolar dopant disrupts anti‐parallel dipole alignment in a polar host, promoting enhanced dipole orientation. Meanwhile, polar‐polar blends can retain their original dipole alignment, resulting in a linear GSP slope trend ...
Siliang He, Abhinav Kapur, Evgeny Pakhomenko, Ryker Rofshus, Russell J. Holmes   +4 more
wiley   +1 more source

Rapid Determination of Association Constants using Routine Plate Reader Measurements

Analysis &Sensing, Volume 6, Issue 1, January 2026.
A high‐throughput plate reader method enables rapid, accurate determination of host–guest binding constants and limits of detection using standard laboratory equipment. The approach is validated across diverse systems and supports machine learning regression, offering a robust analytical tool for supramolecular sensing and quantitative analysis. Though
Austin R. Sartori, Anjusha Prakash, Elnaz Safari, Mikhail Zamkov, Pavel Anzenbacher Jr   +4 more
wiley   +1 more source

A mild and efficient method for the preparation of 3-(2'-Aminoaryl)pyrazoles from 4-chloroquinolines [PDF]

, 2007
We describe a mild and efficient method for the formation of 3-(2'-aminoaryl)pyrazoles in excellent yields from reactions of 4-chloroquinolines with hydrazine.
Alice M. R. Bernardino, Cesar D. de Oliveira, James L. Wardell, Julio C. Borges, Luiz C. da Silva Pinheiro, Misbahul Ain Khan, Roberta K. F. Marra, Solange M. S. V. Wardell   +7 more
core   +1 more source

Activity Profiling of Nitro‐Substituted Di(Hetero)Aryl 1,3,4‐ and 1,2,4‐Oxadiazoles: Antimicrobial, Cholinesterase Inhibition and Antioxidant Potential

Archiv der Pharmazie, Volume 359, Issue 1, January 2026.
Novel nitro‐substituted diaryl 1,3,4‐ and 1,2,4‐oxadiazoles were synthesised via molecular hybridisation of bioactive heterocycles. Selected derivatives exhibited potent antimicrobial activity, including against Mycobacterium tuberculosis and Staphylococcus aureus, and cholinesterase inhibitory activity, with promising selectivity.
Enikő Šikorová, Šárka Štěpánková, Eva Frýbová, Klára Konečná, Jana Korbielová, Markéta Švarcová, Ondřej Janďourek, Václav Pflégr, Szilvia Bősze, Martin Krátký   +9 more
wiley   +1 more source

Speciation of metal complexes of medicinal interest: relationship between solution equilibria and pharmaceutical properties [PDF]

, 2018
Biospeciation of essential and toxic metal ions, metal complexes with biological or medicinal activity are discussed in the paper in order to emphasize the importance of the distribution of metal ions in biological milieu.
Dömötör, Orsolya, Enyedy, Éva Anna, Jakusch, Tamás, Kiss, Tamás   +3 more
core   +2 more sources

Decoding Urease Inhibition: A Comprehensive Review of Inhibitor Scaffolds

ChemMedChem, Volume 21, Issue 2, January 2026.
Representative functional groups known for urease inhibition are reviewed within diverse scaffolds using structure–activity analyses to identify features associated with high inhibitory activity. Urease is a metalloenzyme produced by a wide range of organisms and plays a critical role in nitrogen microbial metabolism by catalyzing the hydrolysis of ...
Nuno Martinho, Natália Aniceto
wiley   +1 more source

Advances in LDHs for corrosion-resistant protection of Mg and Al alloys: A review

Journal of Magnesium and Alloys
Layered double hydroxides (LDHs) as coatings attract much attention in corrosion and protection of light metals due to their interesting properties such as in-situ synthesis, unique layer-stacking structure, tunable composition, and good biocompatibility
Lin Wang, Fen Zhang, Zuo-Jun Jiao, Lan-Yue Cui, Yuan-Ding Huang, Shuo-Qi Li, Cheng-Bao Liu, Rong-Chang Zeng   +7 more
doaj   +1 more source