Results 261 to 270 of about 97,911 (299)

Pentoxifylline stimulates hyperactivation in human spermatozoa

Human Reproduction, 1993
The effects of pentoxifylline on the movement characteristics of human spermatozoa incubated under capacitating conditions were examined using automated digital image analysis. Washed spermatozoa from cryopreserved and fresh normozoospermic, and fresh oligozoospermic semen were incubated in the presence of pentoxifylline (3.6 mM) for 30 min.
V J, Kay, J R, Coutts, L, Robertson
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Cisplatin Resistance Associated with PARP Hyperactivation

Cancer Research, 2013
Abstract Non–small cell lung carcinoma patients are frequently treated with cisplatin (CDDP), most often yielding temporary clinical responses. Here, we show that PARP1 is highly expressed and constitutively hyperactivated in a majority of human CDDP-resistant cancer cells of distinct histologic origin.
Michels, J., Vitale, I., Galluzzi, L., Adam, J., Olaussen, K., Kepp, O., Senovilla, L., Talhaoui, I., Guegan, J., Enot, D., Talbot, M., Robin, A., Girard, Pascal, Orear, C., Lissa, D., Sukkurwala, A., Garcia, P., Behnam-Motlagh, P., Kohno, K., Wu, G., Brenner, Catherine, Dessen, P., Saparbaev, M., Soria, J.-C., Castedo, M., Kroemer, G.   +25 more
openaire   +3 more sources

Participation of signaling proteins in sperm hyperactivation

Systems Biology in Reproductive Medicine, 2022
Sperm hyperactivation is described as a fast whip movement of the flagellum, an irregular trajectory, and an asymmetrically flagellum bend. This motility pattern is achieved during the passage of the sperm along the female genital tract. It helps the spermatozoa to cross through different viscous ambient fluids to finally reach the oocyte.
Joaquín Cordero-Martínez, Guadalupe Elizabeth Jimenez-Gutierrez, Charmina Aguirre-Alvarado, Verónica Alacántara-Farfán, Germán Chamorro-Cevallos, Ana L. Roa-Espitia, Enrique O. Hernández-González, Lorena Rodríguez-Páez   +7 more
openaire   +2 more sources

Hyperactivated Motility in Sperm

Journal of Andrology, 1996
The functions of hyperactivation may fit together to create the following scenario. Sperm that enter the oviduct bind to the mucosal epithelium. Near the time of ovulation, hyperactivation helps them to detach from the epithelium, escape mucosal pockets, and move through oviductal mucus.
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Kinematic definition of ram sperm hyperactivation

Reproduction, Fertility and Development, 1999
Although it is known that ram spermatozoa exhibit hyperactivated motility under capacitating conditions, quantitative analyses of the head and flagellar movement of washed ram spermatozoa have not been published. Motile spermatozoa were recovered from semen by swim-up into HSOF medium, and their movement in 30-µm-deep chambers was videorecorded ...
S T, Mortimer, W M, Maxwell
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Enhanced fertility after heat-induced hyperactivation

Fertility and Sterility, 1998
To determine sperm hyperactivation, kinematic parameters, and fertilizing capacity after pretreating sperm at 40 degrees C for 4 hours.Prospective study involving pooled donor sperm that were colloid washed and incubated at either 23 degrees C (control) or 40 degrees C (heat-treated) for 4 hours as pretreatment.
P J, Chan, J U, Corselli, W C, Patton, J D, Jacobson, A, King   +4 more
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Effect of human tubal fluid medium and hyperactivation inducers on stallion sperm capacitation and hyperactivation

Reproduction in Domestic Animals, 2018
ContentsConventional in vitro fertilization has not yet been implemented in the equine species. One of the main reasons has been the inability to develop a culture medium and incubation conditions supporting high levels of stallion sperm capacitation and hyperactivation in vitro.
Camila Arroyo‐Salvo, Francisco Sanhueza, Fernanda Fuentes, Favián Treulén, María Elena Arias, Paulina Cabrera, Mauricio Silva, Ricardo Felmer   +7 more
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Dissecting hyperactivation in AD

Science, 2019
Neurodegeneration Progressive accumulation of amyloid β (Aβ) in the brain is a defining feature of Alzheimer's disease (AD). At late stages of AD, pathological Aβ accumulations cause neurodegeneration and cell death. However, neuronal dysfunction, consisting of an excessively increased activity in a fraction of brain neurons, already occurs in early ...
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Cerebral hyperactivation across the Alzheimer’s disease pathological cascade

Brain Communications
Abstract Neuronal dysfunction in specific brain regions or across distributed brain networks is a known feature of Alzheimer’s disease. An often reported finding in the early stage of the disease is the presence of increased functional MRI (fMRI) blood oxygenation level-dependent signal under task conditions relative to cognitively ...
Nick Corriveau-Lecavalier, Jenna N Adams, Larissa Fischer   +2 more
exaly   +6 more sources

Early orbitofrontal hyperactivation in obsessive–compulsive disorder

Psychiatry Research: Neuroimaging, 2012
Dysfunctional activity in the orbitofrontal cortex (OFC) is one of the core features in the pathophysiology of obsessive-compulsive disorder (OCD). Neuroimaging studies indicate orbitofrontal hyperactivation during the resting state as well as during symptom provocation, whereas orbitofrontal hypoactivation has been reported during tasks designed to ...
Tobias, Lagemann, Johannes, Rentzsch, Christiane, Montag, Jürgen, Gallinat, Maria, Jockers-Scherübl, Christine, Winter, Friedel Martin, Reischies   +6 more
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