Results 131 to 140 of about 100,236 (366)
Continuing Education in Anaesthesia Critical Care & Pain, 2014 Opioids are a widely used pharmacological therapy for moderate-to-severe pain. Their use in the management of chronic non-cancer pain has escalated in recent years, particularly in North America. This escalation has posed many challenges for prescribers such as lack of longterm effectiveness, misuse and abuse, and the occurrence of adverse side-effects.
Akilan Velayudhan +2 more
openaire +2 more sources
Endometriosis—The scapegoat for pelvic pain?
Acta Obstetricia et Gynecologica Scandinavica, EarlyView.Abstract Cyclic and noncyclic chronic pelvic pain (CPP) represent a major problem for both affected patients and healthcare providers due to its effects on physical and mental health. In times of social media and digitalization, awareness of endometriosis as a leading cause of CPP is increasing.
Gernot Hudelist +3 more
wiley +1 more source
Metabotropic glutamate receptor 2/3 (mGluR2/3) activation suppresses TRPV1 sensitization in mouse, but not human sensory neurons [PDF]
, 2018 The use of human tissue to validate putative analgesic targets identified in rodents is a promising strategy for improving the historically poor translational record of preclinical pain research.
Baranger, David A.A. +5 more
core +2 more sources
Molecular Pain, 2015 BackgroundHyperexcitability of nociceptive afferent fibers is an underlying mechanism of neuropathic pain and ion channels involved in neuronal excitability are potentially therapeutic targets.
A. Abd-Elsayed +6 more
semanticscholar +1 more source
Alimentary Pharmacology &Therapeutics, EarlyView.Over 20% of individuals with IBD were prescribed pain or sedative medications annually, with rising chronic and co‐prescribing rates. Risk factors included female sex, older age, Crohn's disease, and mental health conditions. Targeted interventions are needed to reduce harmful prescribing and promote safer alternatives.
Samantha Baillie +6 more
wiley +1 more source
Perturbations in neuroinflammatory pathways are associated with paclitaxel-induced peripheral neuropathy in breast cancer survivors. [PDF]
, 2019 Paclitaxel is a common chemotherapy drug associated with the development of chronic paclitaxel-induced peripheral neuropathy (PIPN). PIPN is associated with neuroinflammatory mechanisms in pre-clinical studies.
Abrams, Gary +9 more
core
BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates [PDF]
, 2019 © 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.Background: The marked increase in mis-use of prescription opioids has greatly affected our society. One potential solution is to develop improved analgesics which have
Cami-Kobeci, Gerta +9 more
core +4 more sources
THE MECHANISM OF REFERRED PAIN, HYPERALGESIA (CAUSALGIA) AND OF ALCOHOLIC INJECTIONS FOR THE RELIEF OF NEURALGIA [PDF]
, 1921 Joseph M. Byrne
openalex +1 more source
Psilocybin as a novel treatment for chronic pain
British Journal of Pharmacology, EarlyView.Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey +3 more
wiley +1 more source
Journal of Pain Research, 2020 Zhe Zhang, Hongbai Wang, Yuefu Wang, Qipeng Luo, Su Yuan, Fuxia Yan Department of Anesthesiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Fuxia Yan; Su
Zhang Z +5 more
doaj