Results 131 to 140 of about 85,056 (307)

Correlation between Different Psychological Variables in Women with Fibromyalgia with Symptoms of Neurogenic Inflammation: A Cross-Sectional Study

Biomedicines
Fibromyalgia (FM) is a chronic pain syndrome hypothesized to arise from a state of neurogenic inflammation. Mechanisms responsible for pain, as well as psychological variables, are typically altered in this condition.
Víctor Riquelme-Aguado, Alazne Zabarte-del Campo, Guillermo Baviano-Klett, Josué Fernández-Carnero, Antonio Gil-Crujera, Francisco Gómez-Esquer   +5 more
doaj   +1 more source

The Implementation of Persistent Spinal Pain Syndrome (PSPS): Mechanism‐Based Recommendations

Pain Practice, Volume 26, Issue 1, January 2026.
ABSTRACT Background In 2021, the term persistent spinal pain syndrome (PSPS) was introduced. PSPS type 2 (PSPS‐T2) replaced the unsatisfactory term failed back surgery syndrome (FBSS). PSPS type 1 (PSPS‐T1) is a clinical picture of signs and symptoms of FBSS but without prior surgery. PSPS applies to any spinal level.
Simon Thomson, Brian Simpson, Frank J. Huygen, Michael Stanton‐Hicks, Richard B. North, Giancarlo Barolat, Harriet Scott, Rui V. Duarte   +7 more
wiley   +1 more source

Bilateral mechanical and thermal hyperalgesia and tactile allodynia after chronic compression of dorsal root ganglion in mice [PDF]

, 2011
Ronggui Chen, Weiwei Kong, Da-Long Ge, Ceng Luo, San-Jue Hu   +4 more
openalex   +1 more source

Chronic Pain in Parkinson’s Disease: Prevalence, Sex Differences, Regional Anatomy and Comorbidities

Annals of Clinical and Translational Neurology, Volume 12, Issue 12, Page 2422-2432, December 2025.
Chronic pain affected 66.2% of 10,631 individuals with Parkinson's disease, with higher prevalence and severity in females. Pain most often involved the buttocks, lower back, neck, and knees, and was linked to depression, sleep disorders, and osteoarthritis.
Natalia S. Ogonowski, Freddy Chafota, Fangyuan Cao, Amanda Wei Yin Lim, Victor Flores‐Ocampo, Santiago Díaz‐Torres, Zuriel Ceja, Luis M. García‐Marín, Scott F. Farrell, Kishore R. Kumar, Jane Alty, George D. Mellick, Trung Thành Ngô, Miguel E. Rentería   +13 more
wiley   +1 more source

Atenolol Reduces Leishmania major-Induced Hyperalgesia and TNF-α Without Affecting IL-1β or Keratinocyte Derived Chemokines (KC) [PDF]

, 2016
Marc Karam, Rana Merckbawi, Sara Salman, Ali Mobasheri   +3 more
openalex   +1 more source

Nociceptive Nerve‐Derived CGRP Exacerbates Uterine Fibrogenesis in Adenomyosis by Promoting CD140b+ CD146+ Fibroblast Differentiation

Advanced Science, Volume 12, Issue 45, December 4, 2025.
This study investigates adenomyosis fibrosis in relation to nociceptive nerves. Nociceptive nerve‐secreted CGRP promotes RAMP1hi CD140b+ CD146+ fibroblast differentiation into myofibroblasts through ERK activation, causing severe fibrosis. Rimegepant‐induced CGRP/RAMP1 signaling blockade alleviates fibrosis and restores fertility in a mouse model. This
Zi Ye, Anning Zhao, Xia Li, Yanqing Hao, Dong Huang, Jianmin Chen, Tiantian Li, Yangyang Dai, Wenchao Sun, Lie Ma, Songying Zhang, Liaobing Xin   +11 more
wiley   +1 more source

Dual-Acting Peripherally Restricted Delta/Kappa Opioid (CAV1001) Produces Antinociception in Animal Models of Sub-Acute and Chronic Pain

Journal of Pain Research, 2020
Craig T Hartrick,1 Dominic Poulin,2 Rebekka Molenaar,3 Allison Hartrick1 1Caventure Drug Discovery, Bloomfield Hills, MI, USA; 2Charles River Laboratories, Montreal, Canada; 3American Preclinical Services, Minneapolis, MN, USACorrespondence: Craig T ...
Hartrick CT, Poulin D, Molenaar R, Hartrick A   +3 more
doaj  

Synaptic Dysfunction in the Anterior Cingulate Cortex Underlies Pain‐Anxiety Comorbidity in a Mandibular Asymmetry Mouse Model

Advanced Science, Volume 12, Issue 46, December 11, 2025.
This study establishes a mandibular asymmetry (MA) mouse model that recapitulates chronic orofacial pain and anxiety comorbidity. Anterior cingulate cortex (ACC) hyperactivation and synaptic dysfunction are identified as central neural mechanisms underlying these pathologies, with chemogenetic inhibition of ACC CaMKII+ neurons effectively reversing ...
Zhaoyichun Zhang, Yanran Zhang, Jialin Si, Honghui Mao, Feng He, Jin Ning, Guaiguai Ma, Xiaohua Chen, Haoxiang Xiao, Yuanyuan Zhu, Haifeng Zhang, Yifan Lu, Qian Liu, Meng Nian, Shiquan Sun, Shibin Yu, Shengxi Wu, Ze Fan, Zuolin Jin, Jing Huang   +19 more
wiley   +1 more source

Synchronous Primary Hyperparathyroidism and Polycythemia Vera: A Case Report and Literature Review

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Polycythemia vera (PV) is a chronic myeloproliferative neoplasm characterized by increased erythrocytes and commonly associated with JAK2 mutations. Primary hyperparathyroidism (PHPT), which is often caused by a parathyroid adenoma, is a common cause of hypercalcemia.
Maryam Montazeri, Pooria Sobhanian, Seyed Mohammad Sakhaei, Homina Saffar   +3 more
wiley   +1 more source

Risk of Postoperative Hyperalgesia in Adult Patients with Preoperative Poor Sleep Quality Undergoing Open-heart Valve Surgery

Journal of Pain Research, 2020
Zhe Zhang, Hongbai Wang, Yuefu Wang, Qipeng Luo, Su Yuan, Fuxia Yan Department of Anesthesiology, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Fuxia Yan; Su
Zhang Z, Wang H, Wang Y, Luo Q, Yuan S, Yan F   +5 more
doaj