OP002 PAK4 inhibitor reduces remifentanil-induced postoperative hyperalgesia in rat [PDF]
, 2023 Zhang Tianyao +4 more
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Transcranial photobiomodulation with near‐infrared laser induces analgesia in rats
The Journal of Physiology, EarlyView.Abstract figure legend Transcranial photobiomodulation (tPBM) with a 1064 nm laser alleviated pain. Local field potential (LFP) intensity markedly increased following formalin injection, indicating nociceptive activation. However, after tPBM, this formalin‐induced LFP hyperactivation was diminished. Meanwhile, tPBM preserved brain connectivity that was
Zhen Wang +3 more
wiley +1 more source
Investigations of urethral sphincter activity in mice with bladder hyperalgesia before and after drug administration of gabapentin. [PDF]
, 2019 PurposeThis study investigated the effect of gabapentin on lower urinary tract dysfunction focusing on urethral activities and cystitis-induced hyperalgesia in a mouse model of painful bladder syndrome/interstitial cystitis (PBS/IC). The electromyography&
Chang, Huiyi H +7 more
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eFood, Volume 7, Issue 1, February 2026.From farm to pharma, this review details the engineering of quality in medicinal plants through a science‐driven approach: it first elucidates how genetic and environmental factors inscribe the plant's phytochemical and phytopharmacological profile before harvest, and then dissects the postharvest techniques and technologies—chemical and thermal pre ...
Elyas Aryakia
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MedComm, Volume 7, Issue 2, February 2026.Neurons, immune cells, and other cellular components within the disease microenvironment (such as stromal cells and tumor cells) constitute a dynamically evolving ecosystem. Neurons directly modulate immune cell activity and inflammatory responses through the release of neurotransmitters (e.g., norepinephrine and CGRP), while also promoting tumor ...
Xin Guo +11 more
wiley +1 more source
The mutual effect of progesterone and vitamin D in an animal model of peripheral nerve injury
Research in Pharmaceutical SciencesBackground and purpose: Experimental and clinical studies have shown the potential role of progesterone in relieving neural injury. In addition, emerging data on vitamin D, a steroid hormone, have shown its neuroprotective properties.
Sedighe Nasirzadeh +5 more
doaj +1 more source
Bilateral mechanical and thermal hyperalgesia and tactile allodynia after chronic compression of dorsal root ganglion in mice [PDF]
, 2011 Ronggui Chen +4 more
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Peripheral Nerves in Cancer: Regulatory Roles and Therapeutic Strategies
MedComm, Volume 7, Issue 2, February 2026.The interaction between cancer cells and peripheral nerves: (1) tumor cells could induce the growth of new neural axons and constructing a neural fiber network within the tumor tissue through secreting nerve growth factors; (2) nerve‐derived bioactive molecules can induce perineural invasion of tumor and regulate the malignant phenotype of tumor, such ...
Yan Fu +6 more
wiley +1 more source
Dopamine D3 Receptor Antagonism Reverses the Escalation of Oxycodone Self-administration and Decreases Withdrawal-Induced Hyperalgesia and Irritability-Like Behavior in Oxycodone-Dependent Heterogeneous Stock Rats. [PDF]
, 2019 Prescription opioids, such as oxycodone, are highly effective analgesics for clinical pain management, but approximately 25% of patients who are prescribed opioids misuse them, and 5%-10% develop an opioid use disorder (OUD).
de Guglielmo, Giordano +4 more
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Atenolol Reduces Leishmania major-Induced Hyperalgesia and TNF-α Without Affecting IL-1β or Keratinocyte Derived Chemokines (KC) [PDF]
, 2016 Marc Karam +3 more
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