Results 141 to 150 of about 100,236 (366)

Features of central sensitisation in patients with shoulder pain : A feasibility study [PDF]

, 2019
Design. A case-control feasibility study, comparing people with unilateral shoulder pain and pain free controls. Background. Previous studies have suggested that central sensitisation (CS) may be present in people with shoulder pain, mostly based on ...
Herbland, Anthony, Lewis, Jeremy, van Griensven, Hubert   +2 more
core   +1 more source

A Laser-Guided Spinal Cord Displacement Injury in Adult Mice [PDF]

, 2018
Mouse models are unique for studying molecular mechanisms of neurotrauma because of the availability of various genetic modified mouse lines. For spinal cord injury (SCI) research, producing an accurate injury is essential, but it is challenging because ...
Bakare, Adewale A., Fry, Collin M.E., Qu, Wenrui, Shields, Christopher B., Shields, Lisa B.E., Wu, Xiangbing, Xu, Xiao-Ming, Zhang, Yi Ping   +7 more
core   +1 more source

Review of the Performance of Quantitative Sensory Testing Methods to Detect Hyperalgesia in Chronic Pain Patients on Long-term Opioids

Anesthesiology, 2015
Background:Opioid-induced hyperalgesia is a clinical syndrome whereby patients on long-term opioids become more sensitive to pain while taking opioids. Opioid-induced hyperalgesia is characterized by increased pain intensity over time, spreading of pain ...
Nathaniel Katz, F. Paillard, R. Edwards
semanticscholar   +1 more source

Anti‐inflammatory effects of physical stimuli: The central role of networks in shaping the future of pharmacological research

British Journal of Pharmacology, EarlyView.
Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi, Reyhaneh Hooshmandabbasi, Alessandro Ravoni, Ying Ma, Luigi Manni, Timothy J. Koh, Caroline Maake, Tiziana Guarnieri, Darong Lai, Vitalii Zablotskii, Christine Nardini   +10 more
wiley   +1 more source

EXPERIMENTAL HYPERALGESIA [PDF]

, 1980
Itobert H. LaMotte, Charles T. Robinson, Johann G. Thalhaitner, H. E. Torebjörk   +3 more
openalex   +1 more source

Neuromusculoskeletal ultrasound examination in Nicolau syndrome

PM&R, EarlyView.
Beytullah Yazar, Abdullah Emre Uğur, Mustafa Güngör Albayrak, Levent Özçakar   +3 more
wiley   +1 more source

Anti‐nociceptive action of leonurine through TRPA1 and TRPV4 channels modulation

British Journal of Pharmacology, EarlyView.
Background and Purpose Leonurine, a pseudoalkaloid derived from Leonotis leonurus, has been traditionally used in herbal medicine to alleviate conditions such as headaches and abdominal discomfort. Its therapeutic effects are often attributed to potential antioxidant properties; however, the precise molecular mechanisms remain poorly understood ...
Matilde Marini, Lorenzo Landini, Elisabetta Coppi, Martina Tesi, Elisa Bellantoni, Martina Chieca, Emma Beatrice Croce, Lorenzo Bonacchi, Giulia Brancolini, Piero Bruschi, Daniel Souza Monteiro de Araújo, Gaetano De Siena, Alexandra Dimitrova, Alessandra Mastricci, Henrique Rocha Mendonça, Irene Scuffi, Martina Venturini, Luiza Dos Santos Heringer, Fabio Vaiano, Romina Nassini, Francesco De Logu   +20 more
wiley   +1 more source

Central sensitisation as a determinant of patients' benefit from total hip and knee replacement [PDF]

, 2017
BACKGROUND: Discrepancies exist between osteoarthritic joint changes and pain severity before and after total hip (THR) and knee (TKR) replacement. This study investigated whether the interaction between pre‐operative widespread hyperalgesia and severity
Arendt-Nielsen, Bedson, Bellamy, Beswick, Black, Dowsey, Dowsey, Felson, Finan, Goode, Kellgren, Leckie, Lundblad, Martin, Murphy, Neogi, Petersen, Suokas, Valdes, Wylde, Wylde, Wylde, Wylde, Wylde, Wylde, Yarnitsky   +25 more
core   +1 more source

Synthetic microneurotrophins: Neurotrophin receptors for therapeutics of neurodegenerative diseases

British Journal of Pharmacology, EarlyView.
Neurodegenerative disorders are characterised by the chronic progressive degeneration of specific neuronal subtypes, neuroinflammation, myelin damage and synaptic loss. Despite their growing incidence, advancements in effective treatments remain limited, because of lack of knowledge for the aetiology of the diverse pathophysiology to design systematic ...
Ioanna Zota, Theodora Calogeropoulou, Konstantina Chanoumidou, Ioannis Charalampopoulos, Achille Gravanis   +4 more
wiley   +1 more source

Antinociceptive Effect of Vaccinium Myrtillus in Diabetic Rats

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2011
BACKGROUND AND OBJECTIVE: Diabetes mellitus in long-term accompanies with inappropriate complications like retinopathy and neuropathy and increased pain sensation due to neuropathy.
M Roghani, T Baluchnejadmojarad
doaj