Results 141 to 150 of about 98,568 (358)
Current status and future directions of botulinum neurotoxins for targeting pain processing. [PDF]
, 2015 Current evidence suggests that botulinum neurotoxins (BoNTs) A1 and B1, given locally into peripheral tissues such as skin, muscles, and joints, alter nociceptive processing otherwise initiated by inflammation or nerve injury in animal models and humans.
Pellett, Sabine +2 more
core +2 more sources
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Morphine is among the most powerful analgesic, but its long‐term use can cause tolerance. Synaptic ATP supply is critical for maintaining synaptic transmission. Microtubule‐based mitochondrial transport ensures synaptic energy supply.
Zheng Li +9 more
wiley +1 more source
Postherpetic Neuralgia: Irritable Nociceptors and Deafferentation
Neurobiology of Disease, 1998 Postherpetic neuralgia (PHN) is a common and often devastatingly painful condition. It is also one of the most extensively investigated of the neuropathic pains. Patients with PHN have been studied using quantitative testing of primary afferent function,
Howard L. Fields +2 more
doaj
Ovariectomy-induced chronic abdominal hypernociception in rats: Relation with brain oxidative stress [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2015 Context: Ovarian hormone deficiency observed in menopausal women increases the production of reactive oxygen species, which could be implicated in central sensitization subjacent in chronic functional pain syndromes.
Bárbara B. Garrido-Suárez +5 more
doaj
Camphor Attenuates Hyperalgesia in Neuropathic Pain Models in Mice
Journal of Pain Research, 2023 Ziyuan Li,1,* Yu Gan,1,* Ting Kang,1,* Yi Zhao,1 Tianguang Huang,2 Yuhao Chen,3 Jin Liu,1 Bowen Ke1 1Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of ...
Li Z +7 more
doaj
TRPA1 Channel is Involved in SLIGRL-Evoked Thermal and Mechanical Hyperalgesia in Mice
Medical Sciences, 2019 Persistent itch (pruritus) accompanying dermatologic and systemic diseases can significantly impair the quality of life. It is well known that itch is broadly categorized as histaminergic (sensitive to antihistamine medications) or non-histaminergic ...
Merab G. Tsagareli +3 more
doaj +1 more source
Purinergic mechanosensory transduction and visceral pain [PDF]
, 2009 In this review, evidence is presented to support the hypothesis that mechanosensory transduction occurs in tubes and sacs and can initiate visceral pain.
Burnstock, G
core +3 more sources
Cell Proliferation, EarlyView.SHp‐DNase1 combined with CRO inhibits NETs to alleviate intestinal IRI ABSTRACT Neutrophil extracellular traps (NETs) act as a vital first line of defence against tissue damage and pathogens, playing a significant role in improving diseases such as intestinal ischemia reperfusion injury (IRI).
Tingting Liu +12 more
wiley +1 more source
Contrasting alterations to synaptic and intrinsic properties in upper-cervical superficial dorsal horn neurons following acute neck muscle inflammation [PDF]
, 2014 Background: Acute and chronic pain in axial structures, like the back and neck, are difficult to treat, and have incidence as high as 15%. Surprisingly, most preclinical work on pain mechanisms focuses on cutaneous structures in the limbs and animal ...
Baba H +7 more
core +3 more sources