Results 161 to 170 of about 86,101 (292)

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

Prostaglandin levels, vaginal innervation, and cyst innervation as peripheral contributors to endometriosis-associated vaginal hyperalgesia in rodents

, 2016
Stacy L. McAllister, Barbra Giourgas, Elizabeth K. Faircloth, Emma Leishman, Heather B. Bradshaw, Eric R. Gross   +5 more
openalex   +1 more source

Citrus reticulata Blanco: A Review on Chemical Composition and Biological Activities

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
This review compiles chemical information and biological activities from 49 studies on Citrus reticulata. The fruit peels stand out for their high content of methoxylated monoterpenes and flavonoids with antioxidant, anti‐inflammatory, and antimicrobial activities.
José Walber Gonçalves Castro, Geane Gabriele de Oliveira Souza, José Galberto Martins da Costa, Fabíola Fernandes Galvão Rodrigues   +3 more
wiley   +1 more source

Opioid-induced Hyperalgesia in a Murine Model of Postoperative Pain [PDF]

, 2006
Evelyne Célèrier, Juan R González, Rafaël Maldonado, David Cabañero, Margarita M. Puig   +4 more
openalex   +1 more source

Correction to: Neuron-specific biomarkers predict hypo- and hyperalgesia in individuals with diabetic peripheral neuropathy [PDF]

, 2021
Jakob Morgenstern, Jan B. Groener, Johann M. E. Jende, Felix T. Kurz, Alexander Strom, Jens Göpfert, Ζoltan Κender, Maxime Le Marois, Maik Brune, Rohini Kuner, Stephan Herzig, Michael Roden, Dan Ziegler, Martin Bendszus, Julia Szendroedi, Peter P. Nawroth, Stefan Kopf, Thomas Fleming   +17 more
openalex   +1 more source

Catalytic Strategies For the Synthesis of Dehydrozingerone: Structural Features and Emerging Applications—A Critical Review

ChemCatChem, Volume 18, Issue 1, 15 January 2026.
This review emphasizes the main methods for synthesizing dehydrozingerone (DHZ), highlighting the aldol condensation reaction of vanillin with acetone using homogeneous and heterogeneous catalysts. Furthermore, the main pharmacological properties that characterize DHZ are presented, along with current challenges and perspectives in its production ...
Paula Ramirez, José J. Martinez, Gustavo Romanelli, Maria H. Brijaldo, Fabio B. Passos   +4 more
wiley   +1 more source

Evoked Human Oesophageal Hyperalgesia: A Potential Tool for Analgesic Evaluation? [PDF]

, 2009
Anne Estrup Olesen, Camilla Staahl, Christina Brock, Lars Arendt‐Nielsen, Asbjørn Mohr Drewes   +4 more
openalex   +1 more source

PGC‐1α Transcriptionally Regulated by ChREBP Mitigates Neuropathic Pain Through Promoting Microglial Fatty Acid Oxidation and Anti‐Inflammatory Response

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
ChREBP transcriptionally regulates PGC‐1α, which enhances the expression of fatty acid oxidation genes, promotes the fatty acid oxidation process, and thereby increases the polarization of anti‐inflammatory microglia, reduces the level of inflammatory factors, and improves pain symptoms.
Ziwei Hu, Jiahui Pang, Xinli Liu, Yun Zhao, Yi Lu, Hui Chen, Hui Zeng, Youxin Yu, Yubai Zhao, Lijie Gao, Xuefei Zhang, Jian Jin, Kangling Wang, Yu Shi, Hongrui Zhan, Wen Wu   +15 more
wiley   +1 more source

PACAP Alleviates Paclitaxel‐Induced Peripheral Neuropathy by Targeting Oxidative Stress and Mitochondrial Damage via the PGC‐1α Pathway

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
This study demonstrates that PACAP alleviates paclitaxel‐induced peripheral neuropathy in mice. Its protective mechanism involves activating the PGC‐1α pathway to restore mitochondrial function and reduce oxidative stress in sensory neurons. Crucially, PACAP does not interfere with the anti‐tumor efficacy of paclitaxel.
Ruyue Mo, Chuanming Wang, Haibei Hu, Shuqi Shi, Di Cao, Zhenhui Luo, Hua Yang, Mingzhu Zhai, Wuping Sun   +8 more
wiley   +1 more source

Cerebral Activation during Von Frey Filament Stimulation in Subjects with Endothelin-1-Induced Mechanical Hyperalgesia: A Functional MRI Study [PDF]

, 2013
Guy Hans, E. Vandervliet, Kristof Deseure, Paul M. Parizel   +3 more
openalex   +1 more source