Results 161 to 170 of about 84,168 (327)

Anti‐nociceptive action of leonurine through TRPA1 and TRPV4 channels modulation

British Journal of Pharmacology, Volume 182, Issue 22, Page 5469-5488, November 2025.
Background and Purpose Leonurine, a pseudoalkaloid derived from Leonotis leonurus, has been traditionally used in herbal medicine to alleviate conditions such as headaches and abdominal discomfort. Its therapeutic effects are often attributed to potential antioxidant properties; however, the precise molecular mechanisms remain poorly understood ...
Matilde Marini, Lorenzo Landini, Elisabetta Coppi, Martina Tesi, Elisa Bellantoni, Martina Chieca, Emma Beatrice Croce, Lorenzo Bonacchi, Giulia Brancolini, Piero Bruschi, Daniel Souza Monteiro de Araújo, Gaetano De Siena, Alexandra Dimitrova, Alessandra Mastricci, Henrique Rocha Mendonça, Irene Scuffi, Martina Venturini, Luiza Dos Santos Heringer, Fabio Vaiano, Romina Nassini, Francesco De Logu   +20 more
wiley   +1 more source

Effect of Neurotropin on Hyperalgesia Induced by Prostaglandin E2, Naloxone, Melatonin and Dark Condition in Mice

, 1987
Hiroshi Takahashi, Manabu Shibata, Tsuyako Ohkubo, Kihachi Saito, Reizo Inoki   +4 more
openalex   +1 more source

A systematic review of outcomes measured in interventional trials in people with diabetic sensorimotor polyneuropathy

Diabetic Medicine, Volume 42, Issue 11, November 2025.
Abstract Aims Diabetic sensorimotor polyneuropathy (DSPN) is the most common chronic complication of diabetes. Heterogeneity in outcome measures across DSPN trials may have hindered the development of novel therapies. No core outcome set (COS) exists to standardise DSPN trial outcomes.
Galvin Chiam, Sasha Smith, Tony Tu, Amaan Din, Pasha Normahani, Alun Davies   +5 more
wiley   +1 more source

Basic and clinical aspects of visceral hyperalgesia

, 1994
Emeran A. Mayer, Gerald F. Gebhart
openalex   +1 more source

Efficacy of Combined Versus Supplementary Injection Techniques With Inferior Alveolar Nerve Block for Mandibular Molars With Symptomatic Irreversible Pulpitis: A Systematic Review and Network Meta‐Analysis

International Endodontic Journal, Volume 58, Issue 11, Page 1681-1710, November 2025.
ABSTRACT Background Achieving effective anaesthesia in mandibular molars with symptomatic irreversible pulpitis is challenging. Various strategies involving the inferior alveolar nerve block (IANB) have been investigated, such as supplementing with additional injections after IANB failure (SUPP) or combining injections with IANB as primary injections ...
Thanatpong Rujirawan, Sittichoke Osiri, Kanet Chotvorrarak   +2 more
wiley   +1 more source

Effects of selective opiate antagonists on morphine-induced hyperalgesia in domestic fowl

, 1991
Kenneth J. Sufka, Richard A. Hughes, James Giordano   +2 more
openalex   +2 more sources

Palmitoylethanolamide (PEA) Induces an Increase in Spleen Regulatory T Cells, Reduces CD8 + Cells and TNF‐α Levels in Target Organs, and Protects Mice From Graft‐Versus‐Host Disease‐Related Mortality Through PPAR Activation Without Compromising the Graft‐Versus‐Tumour Response

Immunology, Volume 176, Issue 3, Page 385-402, November 2025.
Effect of Palmitoylethanolamide (PEA) in a murine model of graft‐versus‐host disease (GVHD). Following an allogeneic transplant from C57BL/6J donors to BALB/c recipients, PEA treatment improved survival, alleviated clinical symptoms, and protected target organs in GVHD‐affected mice.
Bárbara Betônico Berg, Zara Desiree Tonidandel Campos, Gioconda Muniz Fiorenza Ruggio, Ana Flávia Santos Linhares, Bárbara Maximino Rezende, Stêfany Bruno de Assis Cau, Thiago Roberto Lima Romero, Mauro Martins Teixeira, Vanessa Pinho, Marina Gomes Miranda Castor   +9 more
wiley   +1 more source

Dopamine D3 Receptor Antagonism Reverses the Escalation of Oxycodone Self-administration and Decreases Withdrawal-Induced Hyperalgesia and Irritability-Like Behavior in Oxycodone-Dependent Heterogeneous Stock Rats. [PDF]

, 2019
Prescription opioids, such as oxycodone, are highly effective analgesics for clinical pain management, but approximately 25% of patients who are prescribed opioids misuse them, and 5%-10% develop an opioid use disorder (OUD).
de Guglielmo, Giordano, George, Olivier, Kallupi, Marsida, Newman, Amy H, Sedighim, Sharona   +4 more
core  

Urogynecologic Symptoms Are Not Specific to Anatomic Region of Digestive Symptoms

Neurogastroenterology &Motility, Volume 37, Issue 11, November 2025.
Urogynecologic symptoms are common in patients with DGBIs, regardless of the affected area of the GI tract. We recommend screening for these symptoms in all patients with chronic GI symptoms. ABSTRACT Background/Aims Many patients with digestive symptoms describe underlying urinary or gynecologic symptoms, which may increase visceral sensitivity in the
Madison Simons, Tatini Sal‐Markar, Debolina Ghosh, Suruchi Ramanujan, Xiao Jing Wang, Yuying Luo   +5 more
wiley   +1 more source

Neonatal capsaicin treatment attenuates spinal Fos activation and dynorphin gene expression following peripheral tissue inflammation and hyperalgesia

, 1992
JL Hylden, Koichi Noguchi, MA Ruda
openalex   +1 more source