Results 161 to 170 of about 100,236 (366)
Journal of Neuroendocrinology, EarlyView.Abstract Recent studies have shown a link between disrupted circadian rhythms and the development of chronic opioid‐induced negative effects. Both animal and human studies show a significant bidirectional relationship between the circadian system and opioid effects.
Nasrin Mehranfard +2 more
wiley +1 more source
BiomedicinesFibromyalgia (FM) is a chronic pain syndrome hypothesized to arise from a state of neurogenic inflammation. Mechanisms responsible for pain, as well as psychological variables, are typically altered in this condition.
Víctor Riquelme-Aguado +5 more
doaj +1 more source
The pharmacotherapeutic potential of neuropeptide Y for chronic pain
Journal of Internal Medicine, EarlyView.Abstract Chronic pain is a major medical problem that requires new therapeutic options. Discovered by Victor Mutt in 1982, neuropeptide Y (NPY) is rapidly emerging as a master regulator of pain relief. Genetic knockdown of NPY or pharmacological inhibition of its receptors demonstrates that NPY signaling tonically inhibits indices of chronic ...
Al A. Nie, Bradley K. Taylor
wiley +1 more source
The effect of environment on post surgical overall well-being and pain sensitivity in an animal model [PDF]
, 2016 With chronic post surgical pain affecting up to one third of patients undergoing surgeries and the price of treatment being astoundingly high there has been a transition in research to investigate and identify risk factors. Through identification of risk
Reddy, Archana
core +1 more source
ToxinsAccidents caused by Bothrops jararaca (Bj) snakes result in several local and systemic manifestations, with pain being a fundamental characteristic. The inflammatory process responsible for hyperalgesia induced by Bj venom (Bjv) has been studied; however,
Ariela de Oliveira Pedro Bom +9 more
doaj +1 more source
An isobolographic analysis of the effects of N‐methyl‐D‐aspartate and NK1 tachykinin receptor antagonists on inflammatory hyperalgesia in the rat [PDF]
, 1996 Ke Ren +2 more
openalex +1 more source
Psychophysical changes after total sleep deprivation and experimental muscle pain
Journal of Sleep Research, Volume 34, Issue 2, April 2025.Summary Sleep disturbances exacerbate chronic pain, increase psychological load, and increase inflammation. Delayed onset muscle soreness (DOMS) mimics aspects of chronic pain, predominantly affecting peripheral pain mechanisms, while experimental sleep provocations have been shown to impact central pain mechanisms.
Emma Hertel +5 more
wiley +1 more source
The Potential Role of Glycogen Synthase Kinase-3β in Neuropathy-Induced Apoptosis in Spinal Cord
Basic and Clinical Neuroscience, 2020 Introduction: Glycogen Synthase Kinase-3β (GSK-3β) participates in several signaling pathways and plays a crucial role in neurodegenerative diseases, inflammation, and neuropathic pain. The ratio of phosphorylated GSK-3β over total GSK-3β (p-GSK-3β/t-GSK-
Mina Rashvand +2 more
doaj
Involvement of interleukin‐1β, nerve growth factor and prostaglandin E2 in endotoxin‐induced localized inflammatory hyperalgesia [PDF]
, 1997 Bared Safieh‐Garabedian +5 more
openalex +1 more source
Opioid-induced hyperalgesia: Cellular and molecular mechanisms
Neuroscience, 2016 Laurie-Anne Roeckel +3 more
semanticscholar +1 more source