Results 11 to 20 of about 98,039 (356)
Opioid Induced Hyperalgesia [PDF]
Pain Medicine, 2015 To discuss the phenomenon of opioid induced hyperalgesia (OIH) and investigate the data and clinical recommendations available on this topic.A literature search on the topic of OIH was performed. Relevant studies pertaining to OIH were included in this review.Existing studies and reviews on the pathophysiology, diagnosis, and clinical management of OIH
Peter Pryzbylkowski, Peter Yi
openaire +4 more sources
Progress in Neurobiology, 2014 The importance of the modulation of pain by emotion is now widely recognised. In particular, stress and anxiety, depending on their nature, duration and intensity, can exert potent, but complex, modulatory influences typified by either a reduction or exacerbation of the pain state. Exposure to either acute or chronic stress can increase pain responding
Jennings, Elaine M. +3 more
openaire +4 more sources
Does naloxone reinstate secondary hyperalgesia in humans after resolution of a burn injury? A placebo-controlled, double-blind, randomized, cross-over study. [PDF]
PLoS ONE, 2013 Development of secondary hyperalgesia following a cutaneous injury is a centrally mediated, robust phenomenon. The pathophysiological role of endogenous opioid signalling to the development of hyperalgesia is unclear.
Manuel P Pereira +5 more
doaj +1 more source
Effect of intraoperative infusion of ketamine on remifentanil-induced hyperalgesia [PDF]
Korean Journal of Anesthesiology, 2015 BackgroundOpioid induced hyperalgesia (OIH) is related with high opioid dosage, a long duration of opioid administration, and abrupt discontinuation of infused opioids in anesthetic settings. Ketamine is known to attenuate OIH efficiently, but methods of
Eunji Choi +5 more
doaj +1 more source
Heat emitting damage in skin: a thermal pathway for mechanical algesia [PDF]
, 2021 Mechanical pain (or mechanical algesia) can both be a vital mechanism warning us for dangers or an undesired medical symptom important to mitigate. Thus, a comprehensive understanding of the different mechanisms of this type of pain is paramount. In this work, we study the tearing of porcine skin in front of an infrared camera, and show that mechanical
arxiv +1 more source
Increased Nociceptive Responses in Streptozotocin-Induced Diabetic Rats and the Related Expression of Spinal NR2B Subunit of -Methyl-D-Aspartate Receptors [PDF]
Diabetes & Metabolism Journal, 2019 BackgroundThis study investigated the role of NR2B in a modulated pain process in the painful diabetic neuropathy (PDN) rat using various pain stimuli.MethodsThirty-two Sprague-Dawley male rats were randomly allocated into four groups (n=8): control ...
Che Aishah Nazariah Ismail +4 more
doaj +1 more source
Frontiers in Neuroscience, 2021 This comprehensive review summarizes and interprets the neurobiological correlates of nocebo hyperalgesia in healthy humans. Nocebo hyperalgesia refers to increased pain sensitivity resulting from negative experiences and is thought to be an important ...
Mia A. Thomaidou +10 more
doaj +1 more source
Enterochromaffin Cells: Sentinels to Gut Microbiota in Hyperalgesia?
Frontiers in Cellular and Infection Microbiology, 2021 In recent years, increasing studies have been conducted on the mechanism of gut microbiota in neuropsychiatric diseases and non-neuropsychiatric diseases. The academic community has also recognized the existence of the microbiota-gut-brain axis.
Xiaolin Xu +5 more
doaj +1 more source
Contemporary management of pain in cirrhosis: Toward precision therapy for pain
Hepatology, EarlyView., 2022 Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor healthârelated quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman +4 more
wiley +1 more source
Contribution of Piezo2 to endothelium-dependent pain. [PDF]
, 2015 BackgroundWe evaluated the role of a mechanically-gated ion channel, Piezo2, in mechanical stimulation-induced enhancement of hyperalgesia produced by the pronociceptive vasoactive mediator endothelin-1, an innocuous mechanical stimulus-induced ...
Bogen, Oliver +3 more
core +2 more sources