Ketamine and remote hyperalgesia [PDF]
Minerva Anestesiologica, 2018 Porter, Steven B., Schwenk, Eric S.
openaire +5 more sources
Alterations in prefrontal-limbic functional activation and connectivity in chronic stress-induced visceral hyperalgesia. [PDF]
, 2013 Repeated water avoidance stress (WAS) induces sustained visceral hyperalgesia (VH) in rats measured as enhanced visceromotor response to colorectal distension (CRD).
Bota, Mihail +6 more
core +14 more sources
Does naloxone reinstate secondary hyperalgesia in humans after resolution of a burn injury? A placebo-controlled, double-blind, randomized, cross-over study. [PDF]
PLoS ONE, 2013 Development of secondary hyperalgesia following a cutaneous injury is a centrally mediated, robust phenomenon. The pathophysiological role of endogenous opioid signalling to the development of hyperalgesia is unclear.
Manuel P Pereira +5 more
doaj +1 more source
Inhibition of DAGLβ as a therapeutic target for pain in sickle cell disease
Haematologica, 2022 Sickle cell disease (SCD) is the most common inherited disease. Pain is a key morbidity of SCD and opioids are the main treatment but their side effects emphasize the need for new analgesic approaches.
Iryna A. Khasabova +10 more
doaj +1 more source
Contemporary management of pain in cirrhosis: Toward precision therapy for pain
Hepatology, EarlyView., 2022 Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor healthârelated quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman +4 more
wiley +1 more source
Life, 2021 Musculoskeletal pain is often associated with pain referred to adjacent areas or skin. So far, no study has analyzed the somatosensory changes of the skin after the stimulation of different underlying fasciae.
Walter Magerl +6 more
doaj +1 more source
Sex Difference in Oxytocin-Induced Anti-Hyperalgesia at the Spinal Level in Rats with Intraplantar Carrageenan-Induced Inflammation. [PDF]
PLoS ONE, 2016 Previously, we demonstrated intrathecal administration of oxytocin strongly induced anti-hyperalgesia in male rats. By using an oxytocin-receptor antagonist (atosiban), the descending oxytocinergic pathway was found to regulate inflammatory hyperalgesia ...
Lok-Hi Chow +4 more
doaj +1 more source
Opioid Induced Hyperalgesia [PDF]
Pain Medicine, 2015 To discuss the phenomenon of opioid induced hyperalgesia (OIH) and investigate the data and clinical recommendations available on this topic.A literature search on the topic of OIH was performed. Relevant studies pertaining to OIH were included in this review.Existing studies and reviews on the pathophysiology, diagnosis, and clinical management of OIH
Peter Pryzbylkowski, Peter Yi
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Contribution of Piezo2 to endothelium-dependent pain. [PDF]
, 2015 BackgroundWe evaluated the role of a mechanically-gated ion channel, Piezo2, in mechanical stimulation-induced enhancement of hyperalgesia produced by the pronociceptive vasoactive mediator endothelin-1, an innocuous mechanical stimulus-induced ...
Bogen, Oliver +3 more
core +2 more sources
Individual differences in pain sensitivity are associated with cognitive network functional connectivity following one night of experimental sleep disruption. [PDF]
, 2020 Previous work suggests that sleep disruption can contribute to poor pain modulation. Here, we used experimental sleep disruption to examine the relationship between sleep disruption-induced pain sensitivity and functional connectivity (FC) of cognitive ...
Finan, Patrick H +5 more
core +1 more source