Results 191 to 200 of about 84,168 (327)

ATP in human skin elicits a dose-related pain response which is potentiated under conditions of hyperalgesia [PDF]

open access: bronze, 2000
Sara G. Hamilton   +4 more
openalex   +1 more source

Consolidation, Systematic Appraisal and Comparison of Guideline Recommendations Regarding Management of Chronic Pain: Protocol for a Digital Chronic Pain Recommendation Map

open access: yesClinical and Public Health Guidelines, Volume 2, Issue 4, October 2025.
ABSTRACT Introduction Chronic pain affects 1 in 5 adults and children globally; however, management remains highly variable and low value care is common. Inconsistent recommendations among clinical practice guidelines for management of chronic pain contribute to suboptimal patient management.
Andrea J. Darzi   +48 more
wiley   +1 more source

Adrenergic Control of P2Y6 Receptor‐Dependent Phagocytosis in Rodent and Human Microglia

open access: yesGlia, Volume 73, Issue 10, Page 2025-2034, October 2025.
Main Points Adrenergic signaling through ADRB2 modulates phagocytosis in microglia Crosstalk between ADRB2 and P2Y6 receptors conserved in rodent and human microglia ADRB2 activation inhibits both P2Y6 function and gene expression ABSTRACT Microglia, the resident immune cells of the central nervous system (CNS), are in constant survey of their ...
Thomas Deluc   +10 more
wiley   +1 more source

cZFP609 Tethering BiP Alleviates Cartilage Degradation in Osteoarthritis via Remedying Aberrant ER‐Mitochondrial Contacts

open access: yesMedComm, Volume 6, Issue 10, October 2025.
cZFP609 mediates the cross‐talk between vasculature and cartilage. VSMC‐derived cZFP609 stabilizes the oligomeric form of BiP in chondrocytes, which suppresses TNFα‐induced ER stress signaling and abolishes aberrant ERMC remodeling, and thereby alleviates ferroptosis of chondrocytes and OA progression. ABSTRACT Vascular dysfunction is implicated in the
Yu Song   +12 more
wiley   +1 more source

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