Results 21 to 30 of about 85,056 (307)

Contribution of Piezo2 to endothelium-dependent pain. [PDF]

, 2015
BackgroundWe evaluated the role of a mechanically-gated ion channel, Piezo2, in mechanical stimulation-induced enhancement of hyperalgesia produced by the pronociceptive vasoactive mediator endothelin-1, an innocuous mechanical stimulus-induced ...
Bogen, Oliver, Ferrari, Luiz F, Green, Paul, Levine, Jon D   +3 more
core   +2 more sources

Trigeminal-Rostral Ventromedial Medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injury

Molecular Pain, 2012
Background Our previous studies have shown that complete Freund’s adjuvant (CFA)-induced masseter inflammation and microinjection of the pro-inflammatory cytokine interleukin-1β (IL-1β) into the subnucleus interpolaris/subnucleus caudalis transition zone
Chai Bryan, Guo Wei, Wei Feng, Dubner Ronald, Ren Ke   +4 more
doaj   +1 more source

Pain and Cellular Migration Induced by Bothrops jararaca Venom in Mice Selected for an Acute Inflammatory Response: Involvement of Mast Cells

Frontiers in Immunology, 2022
Bothrops jararaca venom (BjV) can induce mast cell degranulation. In order to investigate the role of mast cells and the interference of the host genetic background in the inflammation induced by BjV, we have used mouse strains selected for maximal ...
Fernanda V. Kondo, Wafa H. K. Cabrera, Orlando G. Ribeiro, Marcelo De Franco, José Ricardo Jensen, Gisele Picolo, Morena B. Sant’Anna, Monica Spadafora-Ferreira, Andrea Borrego, Olga M. Ibañez, Nancy Starobinas   +10 more
doaj   +1 more source

Evaluation of Pain in Acute Pulpitis Hyperalgesia Model Rats

Shiyan dongwu yu bijiao yixue, 2022
ObjectiveTo establish a rat hyperalgesia model of acute pulpitis induced by lipopoly-saccharide (LPS) administration to the maxillary molars. In addition, to analyze and evaluate the acute pain and LPS-induced pulpitis, and to investigate the change of ...
ZHAO Sijia, HE Xinyu, JING Quan, MA Lin, GUO Chunlan, WAN Kuo   +5 more
doaj   +1 more source

Transcriptome-wide analysis of trigeminal ganglion and subnucleus caudalis in a mouse model of chronic constriction injury-induced trigeminal neuralgia

Frontiers in Pharmacology, 2023
Trigeminal neuropathic pain (TNP) induces mechanical allodynia and hyperalgesia, which are known to alter gene expression in injured dorsal root ganglia primary sensory neurons. Non-coding RNAs (ncRNAs) have been linked to TNP.
Xiaona Cui, Xiaona Cui, Xiaona Cui, Bo Qin, Chaoyun Xia, Chaoyun Xia, Hong Li, Hong Li, Zhiye Li, Zhisong Li, Abdul Nasir, Abdul Nasir, Qian Bai, Qian Bai   +13 more
doaj   +1 more source

Contribution of TRPV1 Receptor–Expressing Fibers to Spinal Ventral Root After-Discharges and Mechanical Hyperalgesia in a Spared Nerve Injury (SNI) Rat Model

Journal of Pharmacological Sciences, 2013
Neuropathic pain induces allodynia and hyperalgesia. In the spared nerve injury (SNI) model, marked mechanical hyperalgesia is manifested as prolongation of the duration of paw withdrawal after pin stimulation.
Shohei Yamamoto, Masahiro Ohsawa, Hideki Ono   +2 more
doaj   +1 more source

Basil (Ocimum basilicum) Leaves Essential Oil Ameliorates GluR1 Receptor Expression, TNF-α Level, and Pain-like Behaviors in Post-operative Pain Setting

Bali Journal of Anesthesiology, 2022
Background: Unrelieved post-operative pain is an emerging healthcare concern with ever increasing global volume of surgical procedures. GluR1 subunit coupled with tumor necrosis factor (TNF)-α expression plays a major role in the development of post ...
Dewa Ayu Mas Shintya Dewi, Made Jawi, Nyoman Mantik Astawa, Christopher Ryalino   +3 more
doaj   +1 more source

Molecular Sensors and Modulators of Thermoreception [PDF]

, 2015
Peer ...
Zhang, Xuming
core   +1 more source

Dysregulation of Vesicular Glutamate Transporter VGluT2 via BDNF/TrkB Pathway Contributes to Morphine Tolerance in Mice

Frontiers in Pharmacology, 2022
Morphine is widely used in the treatment of moderate to severe pain. Long-term use of morphine leads to various adverse effects, such as tolerance and hyperalgesia.
Liqiong He, Liqiong He, Wei Xu, Chengliang Zhang, Chengliang Zhang, Zhuofeng Ding, Zhuofeng Ding, Qulian Guo, Qulian Guo, Wangyuan Zou, Wangyuan Zou, Jian Wang, Jian Wang   +12 more
doaj   +1 more source

Role of the endocannabinoid system on the antihyperalgesic action of gabapentin in animal model of neuropathic pain induced by partial sciatic nerve ligation [PDF]

Anais da Academia Brasileira de Ciências, 2020
Gabapentin has antihyperalgesic action, decreasing central sensitization in neuropathic pain models; this effect depends on the mobilization of endogenous pain control pathways.
ALEXANDRE C. BUFFON, MARCELO A. JAVORNIK, ANA C. HEYMANNS, DAIANA C. SALM, VERÔNICA V. HOREWICZ, DANIEL F. MARTINS, ANNA P. PIOVEZAN   +6 more
doaj   +1 more source