Results 21 to 30 of about 100,236 (366)

Evaluation of Pain in Acute Pulpitis Hyperalgesia Model Rats

Shiyan dongwu yu bijiao yixue, 2022
ObjectiveTo establish a rat hyperalgesia model of acute pulpitis induced by lipopoly-saccharide (LPS) administration to the maxillary molars. In addition, to analyze and evaluate the acute pain and LPS-induced pulpitis, and to investigate the change of ...
ZHAO Sijia, HE Xinyu, JING Quan, MA Lin, GUO Chunlan, WAN Kuo   +5 more
doaj   +1 more source

Stress-induced hyperalgesia

Progress in Neurobiology, 2014
The importance of the modulation of pain by emotion is now widely recognised. In particular, stress and anxiety, depending on their nature, duration and intensity, can exert potent, but complex, modulatory influences typified by either a reduction or exacerbation of the pain state. Exposure to either acute or chronic stress can increase pain responding
Jennings, Elaine M., Okine, Bright N., Roche, Michelle, Finn, David P.   +3 more
openaire   +3 more sources

Individual differences in pain sensitivity are associated with cognitive network functional connectivity following one night of experimental sleep disruption. [PDF]

, 2020
Previous work suggests that sleep disruption can contribute to poor pain modulation. Here, we used experimental sleep disruption to examine the relationship between sleep disruption-induced pain sensitivity and functional connectivity (FC) of cognitive ...
Finan, Patrick H, Irwin, Michael R, Letzen, Janelle E, Remeniuk, Bethany, Seminowicz, David A, Smith, Michael T   +5 more
core   +1 more source

Toll-Like Receptor 4 (TLR4)/Opioid Receptor Pathway Crosstalk and Impact on Opioid Analgesia, Immune Function, and Gastrointestinal Motility

Frontiers in Immunology, 2020
Toll-like receptor 4 (TLR4) recognizes exogenous pathogen-associated molecular patterns (PAMPs) and endogenous danger-associated molecular patterns (DAMPs) and initiates the innate immune response.
Peng Zhang, Meirong Yang, Chunhua Chen, Liu Liu, Xinchuan Wei, Si Zeng   +5 more
doaj   +1 more source

Remifentanil-induced postoperative hyperalgesia: current perspectives on mechanisms and therapeutic strategies

Local and Regional Anesthesia, 2018
The use of remifentanil in clinical practice offers several advantages and it is used for a wide range of procedures, ranging from day-surgery anesthesia to more complex procedures.
C. Santonocito, A. Noto, C. Crimi, F. Sanfilippo   +3 more
semanticscholar   +1 more source

Molecular Sensors and Modulators of Thermoreception [PDF]

, 2015
Peer ...
Zhang, Xuming
core   +1 more source

Intrathecal injections of non-peptide oxytocin receptor agonists, WAY 267,464 and TC OT 39, induce significant anti-hyperalgesia in both male and female rats with inflammatory pain [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Hyperalgesia is a clinical condition related to chronic pain in which patients experience increased nociceptive sensitivity. Intrathecal oxytocin has been shown to induce significant anti-hyperalgesia in both rodents and humans. However, in
Lok-Hi Chow, Yuan-Hao Chen, Ying-Jie Chen, Pin-Chen Lin, Eagle Yi-Kung Huang   +4 more
doaj   +1 more source

TNF-Alpha as an Initiator of Allodynia and Anxiety-Like Behaviors in a Preclinical Model of PTSD and Comorbid Pain

Frontiers in Psychiatry, 2021
Post-Traumatic Stress Disorder (PTSD) is a debilitating mental health disorder that occurs after exposure to a traumatic event. Patients with comorbid chronic pain experience affective distress, worse quality of life, and poorer responses to treatments ...
Patrick Dib, Yong Zhang, Michael A. Ihnat, Michael A. Ihnat, Michael A. Ihnat, Randle M. Gallucci, Randle M. Gallucci, Randle M. Gallucci, Kelly M. Standifer, Kelly M. Standifer   +9 more
doaj   +1 more source

Alpha9 nicotinic acetylcholine receptors and the treatment of pain [PDF]

, 2009
Chronic pain is a vexing worldwide problem that causes substantial disability and consumes significant medical resources. Although there are numerous analgesic medications, these work through a small set of molecular mechanisms.
Absalom, Nathan, Chebib, Mary, Elgoyhen, Ana Belen, McIntosh, J. Michael, Vincler, Michelle   +4 more
core   +1 more source

Non-invasive Motor Cortex Neuromodulation Reduces Secondary Hyperalgesia and Enhances Activation of the Descending Pain Modulatory Network

Frontiers in Neuroscience, 2019
Central sensitization is a driving mechanism in many chronic pain patients, and manifests as hyperalgesia and allodynia beyond any apparent injury. Recent studies have demonstrated analgesic effects of motor cortex (M1) stimulation in several chronic ...
T. Meeker, M. Keaser, Shariq A. Khan, R. Gullapalli, D. Seminowicz, J. Greenspan   +5 more
semanticscholar   +1 more source