Results 21 to 30 of about 86,101 (292)

Gabapentin Prevents Oxaliplatin-Induced Mechanical Hyperalgesia in Mice

Journal of Pharmacological Sciences, 2014
.: Oxaliplatin, a platinum-based chemotherapy drug, frequently causes acute and chronic peripheral neuropathies including mechanical hyperalgesia. These adverse effects hinder anticancer therapy with the drug.
Masahiro Ohsawa, Saki Otake, Tomoyasu Murakami, Shohei Yamamoto, Toshiaki Makino, Hideki Ono   +5 more
doaj   +1 more source

Individual differences in pain sensitivity are associated with cognitive network functional connectivity following one night of experimental sleep disruption. [PDF]

, 2020
Previous work suggests that sleep disruption can contribute to poor pain modulation. Here, we used experimental sleep disruption to examine the relationship between sleep disruption-induced pain sensitivity and functional connectivity (FC) of cognitive ...
Finan, Patrick H, Irwin, Michael R, Letzen, Janelle E, Remeniuk, Bethany, Seminowicz, David A, Smith, Michael T   +5 more
core   +1 more source

An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice [PDF]

, 2013
Interleukin (IL)-33, the most recent member of the IL family of cytokines, signals through the ST2 receptor. IL-33/ST2 signaling mediates antigen challenge-induced mechanical hyperalgesia in the joints and cutaneous tissues of immunized mice. The present
Alves-Filho, J.C., Casagrande, R., Cunha, F.Q., Cunha, T.M., Ferreira, S.H., Hohmann, M.S.N., Liew, F.Y., Magro, D.A.C., Mizokami, S.S., Verri Jr, W.A.   +9 more
core   +3 more sources

Molecular Sensors and Modulators of Thermoreception [PDF]

, 2015
Peer ...
Zhang, Xuming
core   +1 more source

Characterization of migraineurs presenting interictal widespread pressure hyperalgesia identified using a tender point count: a cross-sectional study

The Journal of Headache and Pain, 2017
Background Migraineurs exhibit pain hypersensitivity throughout the body during and between migraine headaches. Migraine is classified as a central sensitivity syndrome, typified by fibromyalgia showing widespread pressure hyperalgesia determined by a ...
Toshihide Toriyama, Tetsuyoshi Horiuchi, Kazuhiro Hongo   +2 more
doaj   +1 more source

Alpha9 nicotinic acetylcholine receptors and the treatment of pain [PDF]

, 2009
Chronic pain is a vexing worldwide problem that causes substantial disability and consumes significant medical resources. Although there are numerous analgesic medications, these work through a small set of molecular mechanisms.
Absalom, Nathan, Chebib, Mary, Elgoyhen, Ana Belen, McIntosh, J. Michael, Vincler, Michelle   +4 more
core   +1 more source

Intrathecal injections of non-peptide oxytocin receptor agonists, WAY 267,464 and TC OT 39, induce significant anti-hyperalgesia in both male and female rats with inflammatory pain [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Hyperalgesia is a clinical condition related to chronic pain in which patients experience increased nociceptive sensitivity. Intrathecal oxytocin has been shown to induce significant anti-hyperalgesia in both rodents and humans. However, in
Lok-Hi Chow, Yuan-Hao Chen, Ying-Jie Chen, Pin-Chen Lin, Eagle Yi-Kung Huang   +4 more
doaj   +1 more source

Mas-related G-protein–coupled receptors inhibit pathological pain in mice [PDF]

, 2010
An important objective of pain research is to identify novel drug targets for the treatment of pathological persistent pain states, such as inflammatory and neuropathic pain.
Altier, Baron, Basbaum, Cai, Calignano, Callaghan, Caterina, Chen, Chen, Coderre, Costigan, Costigan, D. J. Anderson, De Felipe, Delmas, Dong, Gerevich, Guan, Guan, Herrero, Honan, Ikeda, Julius, Knabl, Kusudo, Lembo, Li, Li, Liu, Liu, Lu, MacDermott, MacPherson, Malmberg, Melzack, Melzack, Miraucourt, Ndong, Neumann, Q. Liu, Rau, Rodriguez Parkitna, S. N. Raja, Scholz, Seal, Woolf, X. Dong, Y. Guan, Z. Tang, Zeng   +49 more
core   +2 more sources

Advancing the Understanding of Acupoint Sensitization and Plasticity Through Cutaneous C-Nociceptors

Frontiers in Neuroscience, 2022
Acupoint is the key area for needling treatment, but its physiology is not yet understood. Nociceptors, one of the responders in acupoints, are responsible for acupuncture manipulation and delivering acupuncture signals to the spinal or supraspinal level.
Xiang Cui, Kun Liu, Xinyan Gao, Bing Zhu
doaj   +1 more source

Multicenter assessment of quantitative sensory testing (QST) for the detection of neuropathic-like pain responses using the topical capsaicin model [PDF]

, 2018
Background: The use of quantitative sensory testing (QST) in multicenter studies has been quite limited, due in part to lack of standardized procedures among centers. Aim: The aim of this study was to assess the application of the capsaicin pain model
Bushnell, M. Catherine, Chouchou, Florian, Ferland, Catherine E., Gandhi, Wiebke, Jackson, Philip L., Lavigne, Gilles, Ma, My-Linh, Marchand, Serge, Michon, Pierre-Emmanuel, Parent, Alexandre J., Rainville, Pierre, Schweinhardt, Petra, Villemure, Chantal, Ware, Mark A.   +13 more
core   +1 more source