Results 31 to 40 of about 98,039 (356)
The Journal of Headache and Pain, 2017 Background Migraineurs exhibit pain hypersensitivity throughout the body during and between migraine headaches. Migraine is classified as a central sensitivity syndrome, typified by fibromyalgia showing widespread pressure hyperalgesia determined by a ...
Toshihide Toriyama +2 more
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Alpha9 nicotinic acetylcholine receptors and the treatment of pain [PDF]
, 2009 Chronic pain is a vexing worldwide problem that causes substantial disability and consumes significant medical resources. Although there are numerous analgesic medications, these work through a small set of molecular mechanisms.
Absalom, Nathan +4 more
core +1 more source
Supraspinal contributions to hyperalgesia [PDF]
Proceedings of the National Academy of Sciences, 1999 Tissue injury is associated with sensitization of nociceptors and subsequent changes in the excitability of central (spinal) neurons, termed central sensitization. Nociceptor sensitization and central sensitization are considered to underlie, respectively, development of primary hyperalgesia and secondary hyperalgesia. Because central
M. O. Urban, G.F. Gebhart
openaire +3 more sources
Central Amygdala Circuits Mediate Hyperalgesia in Alcohol-Dependent Rats
Journal of Neuroscience, 2018 Alcohol withdrawal symptoms contribute to excessive alcohol drinking and relapse in alcohol-dependent individuals. Among these symptoms, alcohol withdrawal promotes hyperalgesia, but the neurological underpinnings of this phenomenon are not known ...
E. Avegno +8 more
semanticscholar +1 more source
Peripheral nerve repair: a hot spot analysis on treatment methods from 2010 to 2014
Neural Regeneration Research, 2015 Therapeutic strategies for neurological deficits and for promoting nerve regeneration after peripheral nerve injuries have received much focus in clinical research.
Guang-yao Liu +3 more
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Scientific Reports, 2019 Hyperalgesia often occurs in alcoholics, especially during abstinence, yet the underlying mechanisms remain elusive. The lateral habenula (LHb) has been implicated in the pathophysiology of pain and alcohol use disorders.
Seungwoo Kang +8 more
semanticscholar +1 more source
Individual differences in pain sensitivity are associated with cognitive network functional connectivity following one night of experimental sleep disruption. [PDF]
, 2020 Previous work suggests that sleep disruption can contribute to poor pain modulation. Here, we used experimental sleep disruption to examine the relationship between sleep disruption-induced pain sensitivity and functional connectivity (FC) of cognitive ...
Finan, Patrick H +5 more
core +1 more source
Molecular Sensors and Modulators of Thermoreception [PDF]
, 2015 Peer ...
Zhang, Xuming
core +1 more source
Molecular Pain, 2018 Objective Although nociceptive sensitisation is an important pathophysiological process in migraine and migraine chronification, its underlying mechanisms remain unclear. Toll-like receptor 4 (TLR4), a pattern-recognition molecule, has a critical role in
Min Su +7 more
semanticscholar +1 more source
Visualization of trigeminal ganglion sensory neuronal signaling regulated by Cdk5
Cell Reports, 2022 Summary: The mechanisms underlying facial pain are still incompletely understood, posing major therapeutic challenges. Cyclin-dependent kinase 5 (Cdk5) is a key neuronal kinase involved in pain signaling.
Minghan Hu +3 more
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