Results 41 to 50 of about 100,236 (366)

Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. [PDF]

, 2016
Tissue injury, whether by trauma, surgical intervention, metabolic dysfunction, ischemia, or infection, evokes a complex cellular response (inflammation) that is associated with painful hyperalgesic states.
Guan, Zhonghui, Hellman, Judith, Schumacher, Mark   +2 more
core   +2 more sources

Downregulation of M-channels in lateral habenula mediates hyperalgesia during alcohol withdrawal in rats

Scientific Reports, 2019
Hyperalgesia often occurs in alcoholics, especially during abstinence, yet the underlying mechanisms remain elusive. The lateral habenula (LHb) has been implicated in the pathophysiology of pain and alcohol use disorders.
Seungwoo Kang, Jing Li, Wanhong Zuo, Pei Chen, Danielle M. Gregor, Rao Fu, Xiao Han, A. Bekker, J. Ye   +8 more
semanticscholar   +1 more source

Mas-related G-protein–coupled receptors inhibit pathological pain in mice [PDF]

, 2010
An important objective of pain research is to identify novel drug targets for the treatment of pathological persistent pain states, such as inflammatory and neuropathic pain.
Altier, Baron, Basbaum, Cai, Calignano, Callaghan, Caterina, Chen, Chen, Coderre, Costigan, Costigan, D. J. Anderson, De Felipe, Delmas, Dong, Gerevich, Guan, Guan, Herrero, Honan, Ikeda, Julius, Knabl, Kusudo, Lembo, Li, Li, Liu, Liu, Lu, MacDermott, MacPherson, Malmberg, Melzack, Melzack, Miraucourt, Ndong, Neumann, Q. Liu, Rau, Rodriguez Parkitna, S. N. Raja, Scholz, Seal, Woolf, X. Dong, Y. Guan, Z. Tang, Zeng   +49 more
core   +2 more sources

Hyperalgesic effect induced by barbiturates, midazolam and ethanol: pharmacological evidence for GABA-A receptor involvement

Brazilian Journal of Medical and Biological Research, 1997
The involvement of GABA-A receptors in the control of nociception was studied using the tail-flick test in rats. Non-hypnotic doses of the barbiturates phenobarbital (5-50 mg/kg), pentobarbital (17-33 mg/kg), and thiopental (7.5-30 mg/kg), of the ...
M.A.K.F. Tatsuo, C.M. Yokoro, J.V. Salgado, S.M.S. Pesquero, M.A.P. Santana, J.N. Francischi   +5 more
doaj   +1 more source

Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. [PDF]

, 2020
Approximately 25% of patients who are prescribed opioids for chronic pain misuse them, and 5 to 10% develop an opioid use disorder. Although the neurobiological target of opioids is well known, the molecular mechanisms that are responsible for the ...
Carrette, Lieselot LG, de Guglielmo, Giordano, George, Olivier, Kallupi, Marsida, Kononoff, Jenni, Palmer, Abraham A, Schweitzer, Paul, Solberg Woods, Leah C   +7 more
core  

An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice [PDF]

, 2013
Interleukin (IL)-33, the most recent member of the IL family of cytokines, signals through the ST2 receptor. IL-33/ST2 signaling mediates antigen challenge-induced mechanical hyperalgesia in the joints and cutaneous tissues of immunized mice. The present
Alves-Filho, J.C., Casagrande, R., Cunha, F.Q., Cunha, T.M., Ferreira, S.H., Hohmann, M.S.N., Liew, F.Y., Magro, D.A.C., Mizokami, S.S., Verri Jr, W.A.   +9 more
core   +3 more sources

Inhibition of toll-like receptor 4 alleviates hyperalgesia induced by acute dural inflammation in experimental migraine

Molecular Pain, 2018
Objective Although nociceptive sensitisation is an important pathophysiological process in migraine and migraine chronification, its underlying mechanisms remain unclear. Toll-like receptor 4 (TLR4), a pattern-recognition molecule, has a critical role in
Min Su, Y. Ran, Zizi He, Mingjie Zhang, Guanqun Hu, Wenjing Tang, Dengfa Zhao, Shengyuan Yu   +7 more
semanticscholar   +1 more source

Expression profiles of TRPV1, TRPV4, TLR4 and ERK1/2 in the dorsal root ganglionic neurons of a cancer-induced neuropathy rat model

, 2018
Background: The spread of tumors through neural routes is common in several types of cancer in which patients suffer from a moderate-to-severe neuropathy, neural damage and a distorted quality of life.
Elsadek, Bakheet, Maqboul, Ahmad
core   +2 more sources

Multicenter assessment of quantitative sensory testing (QST) for the detection of neuropathic-like pain responses using the topical capsaicin model [PDF]

, 2018
Background: The use of quantitative sensory testing (QST) in multicenter studies has been quite limited, due in part to lack of standardized procedures among centers. Aim: The aim of this study was to assess the application of the capsaicin pain model
Bushnell, M. Catherine, Chouchou, Florian, Ferland, Catherine E., Gandhi, Wiebke, Jackson, Philip L., Lavigne, Gilles, Ma, My-Linh, Marchand, Serge, Michon, Pierre-Emmanuel, Parent, Alexandre J., Rainville, Pierre, Schweinhardt, Petra, Villemure, Chantal, Ware, Mark A.   +13 more
core   +1 more source

Sensitization of neonatal rat lumbar motoneuron by the inflammatory pain mediator bradykinin

eLife, 2015
Bradykinin (Bk) is a potent inflammatory mediator that causes hyperalgesia. The action of Bk on the sensory system is well documented but its effects on motoneurons, the final pathway of the motor system, are unknown.
Mouloud Bouhadfane, Attila Kaszás, Balázs Rózsa, Ronald M Harris-Warrick, Laurent Vinay, Frédéric Brocard   +5 more
doaj   +1 more source