Results 61 to 70 of about 86,101 (292)

Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior [PDF]

, 2006
The S100 family protein p11 (S100A10, annexin 2 light chain) is involved in the trafficking of the voltage-gated sodium channel Na(V)1.8, TWIK-related acid-sensitive K+ channel (TASK-1), the ligand-gated ion channels acid-sensing ion channel 1a (ASIC1a ...
Baker, MD, Dickenson, AH, Foulkes, T, Gerke, V, Lane, T, Matthews, EA, Nassar, MA, Okuse, K, Wood, JN   +8 more
core   +1 more source

Mechanisms of spinal glial activation in chemotherapy‐induced peripheral neuropathy: Focus on microglia and astrocytes

Ibrain, EarlyView.
Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley   +1 more source

Transcriptome-wide analysis of trigeminal ganglion and subnucleus caudalis in a mouse model of chronic constriction injury-induced trigeminal neuralgia

Frontiers in Pharmacology, 2023
Trigeminal neuropathic pain (TNP) induces mechanical allodynia and hyperalgesia, which are known to alter gene expression in injured dorsal root ganglia primary sensory neurons. Non-coding RNAs (ncRNAs) have been linked to TNP.
Xiaona Cui, Xiaona Cui, Xiaona Cui, Bo Qin, Chaoyun Xia, Chaoyun Xia, Hong Li, Hong Li, Zhiye Li, Zhisong Li, Abdul Nasir, Abdul Nasir, Qian Bai, Qian Bai   +13 more
doaj   +1 more source

Hell's Itch: An Acute Reaction to Sunburn Exposure

JEADV Clinical Practice, EarlyView.
ABSTRACT Hell's itch is a neurocutaneous dysesthesia following sunburn that is underreported in scientific literature despite considerable discussion online. ‘Hell's itch’ describes an acute, uncontrollable itch with intense stabbing pain several days post‐sunburn and often follows an inciting event such as water exposure.
Colin Kelly, Connor Stonesifer, Brian W. Morrison   +2 more
wiley   +1 more source

Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development

Molecules, 2020
Pathological pain can be initiated after inflammation and/or peripheral nerve injury. It is a consequence of the pathological functioning of the nervous system rather than only a symptom. In fact, pain is a significant social, health, and economic burden
Camila R. Ferraz, Thacyana T. Carvalho, Marília F. Manchope, Nayara A. Artero, Fernanda S. Rasquel-Oliveira, Victor Fattori, Rubia Casagrande, Waldiceu A. Verri   +7 more
doaj   +1 more source

Effects of 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline on a diabetic neuropathic pain model

Frontiers in Pharmacology, 2023
Background: Neuropathy is a prevalent and debilitating complication of poorly managed diabetes, contributing towards poor quality of life, amputation risk, and increased mortality.
Ahmed Tokhi, Zainab Ahmed, Mehreen Arif, Naeem Ur Rehman, Vahid Sheibani, Robert D. E. Sewell, Khalid Rauf   +6 more
doaj   +1 more source

Endocannabinoid-related compounds in gastrointestinal diseases [PDF]

, 2018
The endocannabinoid system (ECS) is an endogenous signalling pathway involved in the control of several gastrointestinal (GI) functions at both peripheral and central levels.
Alessandra, D'Alessandro, Esposito, Giuseppe, Gigli, Stefano, Giovanni, Sarnelli, Marcella, Pesce, Osvaldo, Borrelli, Rosario, Cuomo, Seguella, Luisa   +7 more
core   +1 more source

Ultrasound‐Guided Liposomal vs. Conventional Bupivacaine Erector Spinae Plane Block Plus Gabapentin for Postherpetic Neuralgia

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to compare efficacy and safety of ultrasound‐guided erector spinae plane block (ESPB) using liposomal (LB) versus conventional bupivacaine (CB), each plus standardized gabapentin, in patients with postherpetic neuralgia (PHN). A total of 116 PHN patients were randomized to ESPB‐LB or ESPB‐CB; both groups received standardized ...
Xia‐Jing Xu, Li‐Juan Liu, Fa‐Ming Xu, Xiang‐Yu Fang   +3 more
wiley   +1 more source

Dejerine-Roussy Syndrome: Understanding Chronic Thalamic Pain [PDF]

Journal of Clinical and Diagnostic Research
A 50-year-old male, known to be hypertensive and non compliant with medications, with a significant past history of stroke three months ago, presented to the hospital with chief complaints of persistent burning sensations in his left arm and leg, as well
Saket S Toshniwal, Jiwan Kinkar, Yatika Chadha, Sourya Acharya, Sunil Kumar   +4 more
doaj   +1 more source

Effects of esketamine on postoperative rebound pain in patients undergoing unilateral total knee arthroplasty: a single-center, randomized, double-blind, placebo-controlled trial protocol

Frontiers in Neurology, 2023
IntroductionRebound pain, transient and acute postoperative pain after the disappearance of regional block anesthesia, has been a concern in recent years.
Youzhuang Zhu, Qun Li, Guilin Liu, Fang Sheng, Xiaotian Zhang, Lili Jiang, Shaona Li, Jianshuai He, Zhijin Zou, Baobo Zhang, Changyao Wang, Xin Jiang, Yang Zhao   +12 more
doaj   +1 more source