Results 41 to 50 of about 925 (106)

Free Radicals in Health and Disease

MedComm, Volume 6, Issue 10, October 2025.
Free radicals have dual roles that can either selectively create oxidative damages to transformed cells in treating proliferative diseases such as cancers and some dermatological disorders or boost the antioxidant system in treating degenerative diseases such as neurodegenerative disorder, joint degeneration, and metabolic conditions.
Xiaofeng Dai, Zizheng Huang, Ruohan Lyu
wiley   +1 more source

Signaling pathways involved in HSP32 induction by hyperbaric oxygen in rat spinal neurons

Redox Biology, 2016
Spinal cord injury (SCI) is a debilitating disease, effective prevention measures are in desperate need. Our previous work found that hyperbaric oxygen (HBO) preconditioning significantly protected rats from SCI after stimulated diving, and in vitro ...
Guoyang Huang, Jiale Diao, Hongjie Yi, Li Xu, Jiajun Xu, Weigang Xu   +5 more
doaj   +1 more source

Diabetic Wound Repair: From Mechanism to Therapeutic Opportunities

MedComm, Volume 6, Issue 10, October 2025.
Diabetic wound healing is compromised by chronic metabolic dysfunction that disrupts essential cellular processes. This review examines key predisposing factors, including neuropathy and vascular disease, characterizes dysfunction in critical cell types such as macrophages and fibroblasts, evaluates limitations of current models, compares established ...
Renyuan Wang, Song Gu, Young Hwa Kim, Aejin Lee, Haodong Lin, Dongsheng Jiang   +5 more
wiley   +1 more source

Hyperbaric oxygen therapy aggravates liver reperfusion injury in rats Oxigenoterapia hiperbárica agrava lesão de reperfusão hepática em ratos

Acta Cirúrgica Brasileira, 2008
PURPOSE: To evaluate the effects of hyperbaric oxygen (HO) therapy in the protection against liver ischemia/reperfusion injury. METHODS: Thirty-two male Wistar rats were divided into four groups of eight animals each: group A - laparotomy and liver ...
Cristiano Xavier Lima, Marcelo Dias Sanches, João Baptista de Rezende Neto, Roberto Carlos de Oliveira e Silva, Mauro Martins Teixeira, Danielle da Glória de Souza, Guilherme de Castro Santos, José Renan da Cunha Melo   +7 more
doaj   +1 more source

The effects and mechanisms of stem cells and exosomes on neurological function protection and recovery after ischemic stroke

Neuroprotection, Volume 3, Issue 3, Page 266-279, September 2025.
Effect and mechanism of stem cells and exosomes therapy in ischemic stroke. The effect and mechanism include protection of neuron and glial cells, repairment of nerve vascular unit, reduction of inflammation response, restoration of white matter integrity, reconstruction of neural circuit, replacement of neurons and glial cells, and anti‐ferroptosis ...
Weihong Du, Yuxian He, Liangchen Li, Xinchun Jin, Panpan Geng   +4 more
wiley   +1 more source

Regulatory Dynamics of Nrf2 With Sirtuins in the Brain: Exploring Cellular Metabolism, Synaptic Plasticity, and Defense Mechanisms

Journal of Neurochemistry, Volume 169, Issue 9, September 2025.
Nuclear factor erythroid 2–related factor 2 (Nrf2) plays a pivotal role as a transcription factor at the heart of cellular defense mechanisms against oxidative stress, orchestrating a suite of cytoprotective genes. This review places particular emphasis on the interplay between Nrf2 and Sirtuins—NAD+‐dependent deacetylases integral to redox regulation,
Efrain J. Perez Lao, Eric Fagerli, Fernando Ferrier, Juan I. Young, Miguel A. Perez‐Pinzon   +4 more
wiley   +1 more source

Case report: Is bilateral renal dioctophymosis and severe uremia in a dog synonymous of euthanasia? Not today

Frontiers in Veterinary Science
A dog with bilateral renal dioctophymosis presented with stage 5 acute kidney injury, weight loss, vomiting, apathy, and hematuria. Laboratory tests showed creatinine of 17.2 mg/dL and Dioctophyme renale eggs in the urine.
Pâmela Caye, Jean Carlos Gasparotto, Anna Vitória Hörbe, Letícia Rodrigues Leitao Andrade, Rainer da Silva Reinstein, Luiza Tonietto Mangini, Daniel Curvello de Mendonça Müller, Maurício Veloso Brun, Maurício Veloso Brun   +8 more
doaj   +1 more source

The Role of Astrocytes in Poststroke Rehabilitation

Brain and Behavior, Volume 15, Issue 6, June 2025.
Contributions of astrocytes to neuroprotection in different types of rehabilitation after ischemic stroke. ABSTRACT Introduction Ischemic stroke is a leading cause of death and chronic disability worldwide. Therapeutic options to reduce stroke‐related disability are still limited.
Ying Han, Li Huang, Jiaojiao Wu, Guiling Wan, Linhong Mo, Aixian Liu   +5 more
wiley   +1 more source

Sirtuin1 in Spinal Cord Injury: Regulatory Mechanisms, Microenvironment Remodeling and Therapeutic Potential

CNS Neuroscience &Therapeutics, Volume 31, Issue 2, February 2025.
Sirtuin 1 (Sirt1), a key NAD+‐dependent deacetylase, has become a leading therapeutic target for spinal cord injury (SCI) repair due to its regulation of multiple pathological processes, including inflammation, oxidative stress, and cell death. Sirt1 not only protects and regenerates neurons but also modulates astrocytes, microglia, oligodendrocytes ...
Jinze Li, Shengyu Cui, Yanqiu Li, Can Zhang, Chao Chang, Fengzeng Jian   +5 more
wiley   +1 more source

Hyperbaric oxygen preconditioning rescues prolonged underwater exercise-induced hippocampal dysfunction by regulating microglia activation and polarization

Neuroscience Research
Underwater exercise is becoming increasingly prevalent, during which brain function is necessary but is also at risk. However, no study has explored how prolonged exercise affect the brain in underwater environment.
Houyu Zhao, Kun Liang, Zeyuan Yu, Yukun Wen, Jin Shi, Tingting Zhang, Xuhua Yu, Xianpeng Zu, Yiqun Fang   +8 more
doaj   +1 more source