Results 131 to 140 of about 2,864 (178)
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Phytochemistry, 2006
Hyperforin is a polyprenylated acylphloroglucinol derivative from Hypericum perforatum (St. John's wort). It exhibits antidepressant activity by a novel mechanism of action, antibiotic activity against gram-positive bacteria, and antitumoral activity in vivo. However, it also produces drug-drug interactions by activation of the pregnan X receptor.
Ludger Beerhues
exaly +3 more sources
Hyperforin is a polyprenylated acylphloroglucinol derivative from Hypericum perforatum (St. John's wort). It exhibits antidepressant activity by a novel mechanism of action, antibiotic activity against gram-positive bacteria, and antitumoral activity in vivo. However, it also produces drug-drug interactions by activation of the pregnan X receptor.
Ludger Beerhues
exaly +3 more sources
European Neuropsychopharmacology, 2005
Hyperforin is one of the possible active principles mediating the antidepressant activity of Hypericum perforatum L. extracts. The ester derivative IDN 5491 (hyperforin-trimethoxybenzoate) showed antidepressant-like properties in the forced swimming test (FST) in rats, with no effect on open-field activity, when given as three intraperitoneal ...
Marco Gobbi +2 more
exaly +3 more sources
Hyperforin is one of the possible active principles mediating the antidepressant activity of Hypericum perforatum L. extracts. The ester derivative IDN 5491 (hyperforin-trimethoxybenzoate) showed antidepressant-like properties in the forced swimming test (FST) in rats, with no effect on open-field activity, when given as three intraperitoneal ...
Marco Gobbi +2 more
exaly +3 more sources
DNA-protective activities of hyperforin and aristoforin
Toxicology in Vitro, 2015The aim of this study was to explain the molecular mechanisms of action of hyperforin, a phluoroglucinol derivative found in Hypericum perforatum L. and its more stable derivative aristoforin. DNA-topology assay revealed partial DNA-protective activities of hyperforin and aristoforin against Fe(2+)-induced DNA breaks.
Martina Šemeláková +2 more
exaly +7 more sources
Hyperforin as a possible antidepressant component of hypericum extracts
Life Sciences, 1998We demonstrate that the phloroglucinol derivative hyperforin is not only the major lipophilic chemical constituent of the medicinal plant Hypericum perforatum (St. John's wort) but also a potent uptake inhibitor of serotonin (5-HT), dopamine (DA), noradrenaline (NA), GABA and L-Glutamate with IC50 values of about 0.05-0.10 microg/ml (5-HT, NA, DA, GABA)
S K Bhattacharya
exaly +3 more sources
Oxidation products of hyperforin from Hypericum perforatum
Phytochemistry, 1998 The isolation of two oxidation products of hyperforin from the aerial parts of Hypericum perforatum and their structure determination by means of 2D NMR methods is reported. The products had the same 1-(2-methyl-1-oxopropyl)-2,12-dioxo-3,10 beta-bis(3-methyl-2-butenyl)-11 beta-methyl-11 alpha-(4-methyl-3-pentenyl)-5-oxatricyclo[6.3.1.0(4,8)]-3-dodec ...
Trifunović, Snežana +6 more
openaire +5 more sources
Hyperforin modifies neuronal membrane properties in vivo
Neuroscience Letters, 2004 Hyperforin, the major active constituent of St. John Wort (SJW) extract, affects several neurotransmitter systems in the brain putatively by modulation of the physical state of neuronal membranes.
Michael Karas +2 more
exaly +2 more sources
Photochemical Degradation of Hyperforin
Letters in Organic Chemistry, 2008Irradiation of hyperforin in acetonitrile gave a single degradation product with a first order kinetics (k = 3.23 M h(-1)). The degradation product was a 1:1 tautomeric mixture of 2-methyl-3-hydroxy-4-(1-oxo-2-methyl-1-propyl)-1, 5dioxo-6-(3-methyl-1-but-2-enyl)-2-cyclohexene and 2-methyl-1, 3, 5-trioxo-4-(1-hydroxy-2-methyl-1-propylene)-6-(3-methyl-1 ...
D'AURIA, Maurizio +2 more
openaire +3 more sources
Journal of the American Chemical Society, 2015
A 10-step total synthesis of the polycyclic polyprenylated acylphloroglucinol (PPAP) natural product hyperforin from 2-methylcyclopent-2-en-1-one is reported. This route was enabled by a diketene annulation reaction and an oxidative ring expansion strategy designed to complement the presumed biosynthesis of this complex meroterpene.
Chi P, Ting, Thomas J, Maimone
openaire +2 more sources
A 10-step total synthesis of the polycyclic polyprenylated acylphloroglucinol (PPAP) natural product hyperforin from 2-methylcyclopent-2-en-1-one is reported. This route was enabled by a diketene annulation reaction and an oxidative ring expansion strategy designed to complement the presumed biosynthesis of this complex meroterpene.
Chi P, Ting, Thomas J, Maimone
openaire +2 more sources
Enantioselective Total Synthesis of Hyperforin and Pyrohyperforin
Angewandte Chemie International Edition, 2022AbstractCapitalizing on the late‐stage diversification of an essential 1,3‐diene intermediate, we describe herein a 9‐step enantioselective total synthesis of (+)‐hyperforin and (+)‐pyrohyperforin, starting from commercially available allylacetone. Our convergent synthesis features a series of critical reactions: 1) an enantioselective deconjugative α ...
Yunpeng Ji +6 more
openaire +2 more sources
Hyperforin: To Be or Not to Be an Activator of TRPC(6)
2015Meantime, it is well accepted that hyperforin, the chemical instable phloroglucinol derivative of Hypericum perforatum, St. John's wort, is the pharmacophore of St. John's wort extracts. With the decline of this scientific discussion, another controversial aspect has been arisen, the question regarding the underlying mechanism leading to the ...
Kristina, Friedland +1 more
openaire +2 more sources