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Hyperforin - Antidepressant Activity by a Novel Mechanism of Action
Pharmacopsychiatry, 2001Hyperforin represents a major antidepressive constituent of St. John's wort (SJW) extract. It not only inhibits the neuronal uptake of serotonin, norepinephrine and dopamine like many other antidepressants, but also inhibits GABA and L-glutamate uptake.
W E, Müller, A, Singer, M, Wonnemann
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Hyperforin acts as an angiogenesis inhibitor.
Planta medica, 2006Hyperforin is a plant compound from Hypericum perforatum that inhibits tumor cell proliferation in vitro by induction of apoptosis. Here, we report that hyperforin also acts as an angiogenesis inhibitor in vitro and in vivo. In vitro, hyperforin blocked microvessel formation of human dermal microvascular endothelial cells (HDMEC) on a complex ...
Christoph M, Schempp +8 more
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Proceedings of the Symposium on Progress in Organic Reactions and Syntheses, 2009
Shimizu, Yohei +4 more
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Shimizu, Yohei +4 more
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Determination of hypericin and hyperforin content in selected Jordanian Hypericum species
Industrial Crops and Products, 2010Feras Alali +2 more
exaly