Results 171 to 180 of about 4,383 (214)

Hyperforin modifies neuronal membrane properties in vivo

Neuroscience Letters, 2004
Hyperforin, the major active constituent of St. John Wort (SJW) extract, affects several neurotransmitter systems in the brain putatively by modulation of the physical state of neuronal membranes. Accordingly, we tested the effects of SJW extract and of hyperforin on the properties of murine brain membrane fluidity.
Dietrich A Volmer
exaly   +4 more sources

Enantioselective Total Synthesis of Hyperforin and Pyrohyperforin

Angewandte Chemie International Edition, 2022
AbstractCapitalizing on the late‐stage diversification of an essential 1,3‐diene intermediate, we describe herein a 9‐step enantioselective total synthesis of (+)‐hyperforin and (+)‐pyrohyperforin, starting from commercially available allylacetone. Our convergent synthesis features a series of critical reactions: 1) an enantioselective deconjugative α ...
Yunpeng Ji, Benke Hong, Ivan Franzoni, Mengyang Wang, Weiqiang Guan, Hongli Jia, Houhua Li   +6 more
openaire   +2 more sources

DNA-protective activities of hyperforin and aristoforin

Toxicology in Vitro, 2015
The aim of this study was to explain the molecular mechanisms of action of hyperforin, a phluoroglucinol derivative found in Hypericum perforatum L. and its more stable derivative aristoforin. DNA-topology assay revealed partial DNA-protective activities of hyperforin and aristoforin against Fe(2+)-induced DNA breaks.
Andrea Sevcovicova, Martina Semelakova, Maria Kozurkova   +2 more
exaly   +3 more sources

Oxidation products of hyperforin from Hypericum perforatum

Phytochemistry, 1998
The isolation of two oxidation products of hyperforin from the aerial parts of Hypericum perforatum and their structure determination by means of 2D NMR methods is reported. The products had the same 1-(2-methyl-1-oxopropyl)-2,12-dioxo-3,10 beta-bis(3-methyl-2-butenyl)-11 beta-methyl-11 alpha-(4-methyl-3-pentenyl)-5-oxatricyclo[6.3.1.0(4,8)]-3-dodec ...
Trifunović, Snežana, Vajs, Vlatka, Macura, Slobodan, Juranić, Nenad, Djarmati, Z, Jankov, Ratko, Milosavljević, Slobodan   +6 more
openaire   +4 more sources

ChemInform Abstract: THE STRUCTURE OF HYPERFORIN

Chemischer Informationsdienst, 1975
AbstractDas antibiotisch gegenüber gram‐positiven Bakterien wirksame Hyperforin besitzt die Struktur (I).
N. S. BYSTROV, B. K. CHERNOV, V. N. DOBRYNIN, M. N. KOLOSOV   +3 more
openaire   +1 more source

Pharmacological activity of hyperforin acetate in rats

Behavioural Pharmacology, 2002
Hyperforin, the main antidepressant component of Hypericum extract, is not stable with regard to heat and light. Therefore, we investigated a newly synthetized derivative, hyperforin acetate. Herein we demonstrate its efficacy in animal models sensitive to antidepressant and anxiolytic drugs.
P, Zanoli, M, Rivasi, C, Baraldi, M, Baraldi   +3 more
openaire   +2 more sources

Biotechnological production of hyperforin for pharmaceutical formulation

European Journal of Pharmaceutics and Biopharmaceutics, 2018
Hyperforin is a major active constituent of Hypericum perforatum (St. John's wort). It has amazing pharmacological activities, such as antidepressant properties, but it is labile and difficult to synthesize. Its sensitivity and lipophilicity are challenges for processing and formulation.
Mariam, Gaid, Eline, Biedermann, Jendrik, Füller, Paul, Haas, Sönke, Behrends, Rainer, Krull, Stephan, Scholl, Ute, Wittstock, Christel, Müller-Goymann, Ludger, Beerhues   +9 more
openaire   +2 more sources

The first prenylation step in hyperforin biosynthesis

Phytochemistry, 2005
Prenylation reactions contribute considerably to the diversity of natural products. Polyprenylated secondary metabolites include hyperforin which is both quantitatively and pharmacologically a major constituent of the medicinal plant Hypericum perforatum (St. John's wort). Cell cultures of the related species Hypericum calycinum were found to contain a
Zakia, Boubakir, Till, Beuerle, Benye, Liu, Ludger, Beerhues   +3 more
openaire   +2 more sources

Hyperforin production in Hypericum perforatum root cultures

Journal of Biotechnology, 2016
Extracts of the medicinal plant Hypericum perforatum are used to treat depression and skin irritation. A major API is hyperforin, characterized by sensitivity to light, oxygen and temperature. Total synthesis of hyperforin is challenging and its content in field-grown plants is variable.
Mariam, Gaid, Paul, Haas, Till, Beuerle, Stephan, Scholl, Ludger, Beerhues   +4 more
openaire   +2 more sources

Hyperforin in St. John’s wort drug interactions

European Journal of Clinical Pharmacology, 2006
Recently, interactions of herbal medicines with synthetic drugs came into focus of particular interest. In the past 3 years, more than 50 papers were published regarding interactions between St. John's wort (Hypericum perforatum L.; SJW) and prescription drugs.
Rajanikanth, Madabushi, Bruno, Frank, Bernd, Drewelow, Hartmut, Derendorf, Veronika, Butterweck   +4 more
openaire   +2 more sources