Results 161 to 170 of about 4,383 (214)
Discovery of a novel piperazine derivative, cmp2: a selective TRPC6 activator suitable for treatment of synaptic deficiency in Alzheimer's disease hippocampal neurons. [PDF]
Sci RepZernov N +5 more
europepmc +1 more source
Dose-dependent induction of CYP3A activity by St. John's wort alone and in combination with rifampin. [PDF]
Clin Transl SciHohmann N +5 more
europepmc +1 more source
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Phytochemistry, 2006
Hyperforin is a polyprenylated acylphloroglucinol derivative from Hypericum perforatum (St. John's wort). It exhibits antidepressant activity by a novel mechanism of action, antibiotic activity against gram-positive bacteria, and antitumoral activity in vivo. However, it also produces drug-drug interactions by activation of the pregnan X receptor.
Ludger Beerhues
exaly +3 more sources
Hyperforin is a polyprenylated acylphloroglucinol derivative from Hypericum perforatum (St. John's wort). It exhibits antidepressant activity by a novel mechanism of action, antibiotic activity against gram-positive bacteria, and antitumoral activity in vivo. However, it also produces drug-drug interactions by activation of the pregnan X receptor.
Ludger Beerhues
exaly +3 more sources
Photochemical Degradation of Hyperforin
Letters in Organic Chemistry, 2008Irradiation of hyperforin in acetonitrile gave a single degradation product with a first order kinetics (k = 3.23 M h(-1)). The degradation product was a 1:1 tautomeric mixture of 2-methyl-3-hydroxy-4-(1-oxo-2-methyl-1-propyl)-1, 5dioxo-6-(3-methyl-1-but-2-enyl)-2-cyclohexene and 2-methyl-1, 3, 5-trioxo-4-(1-hydroxy-2-methyl-1-propylene)-6-(3-methyl-1 ...
D'AURIA, Maurizio +2 more
openaire +3 more sources
Hyperforin activates nonselective cation channels (NSCCs) [PDF]
British Journal of Pharmacology, 2005 A large body of evidence supports the preclinical antidepressant profile of hyperforin including inhibition of the synaptosomal uptake of several neurotransmitters by hyperforin and studies in behavioural models. In contrast to other antidepressants, hyperforin does not directly inhibit neurotransmitter transporters, but instead uptake inhibition ...
Kristina, Treiber +3 more
exaly +3 more sources
Journal of the American Chemical Society, 2015
A 10-step total synthesis of the polycyclic polyprenylated acylphloroglucinol (PPAP) natural product hyperforin from 2-methylcyclopent-2-en-1-one is reported. This route was enabled by a diketene annulation reaction and an oxidative ring expansion strategy designed to complement the presumed biosynthesis of this complex meroterpene.
Chi P, Ting, Thomas J, Maimone
openaire +2 more sources
A 10-step total synthesis of the polycyclic polyprenylated acylphloroglucinol (PPAP) natural product hyperforin from 2-methylcyclopent-2-en-1-one is reported. This route was enabled by a diketene annulation reaction and an oxidative ring expansion strategy designed to complement the presumed biosynthesis of this complex meroterpene.
Chi P, Ting, Thomas J, Maimone
openaire +2 more sources
European Neuropsychopharmacology, 2005
Hyperforin is one of the possible active principles mediating the antidepressant activity of Hypericum perforatum L. extracts. The ester derivative IDN 5491 (hyperforin-trimethoxybenzoate) showed antidepressant-like properties in the forced swimming test (FST) in rats, with no effect on open-field activity, when given as three intraperitoneal ...
Luigi, Cervo +11 more
openaire +2 more sources
Hyperforin is one of the possible active principles mediating the antidepressant activity of Hypericum perforatum L. extracts. The ester derivative IDN 5491 (hyperforin-trimethoxybenzoate) showed antidepressant-like properties in the forced swimming test (FST) in rats, with no effect on open-field activity, when given as three intraperitoneal ...
Luigi, Cervo +11 more
openaire +2 more sources