Results 31 to 40 of about 31,250 (276)

Cystathionine β-synthase and methylenetetrahydrofolate reductase mutations in Mexican individuals with hyperhomocysteinemia

SAGE Open Medicine, 2020
Background: Hyperhomocysteinemia, a thrombotic risk factor, may have several causes. Among the genetic causes of hyperhomocysteinemia, there are polymorphisms in the enzymes methylenetetrahydrofolate reductase (C677T) and cystathionine β-synthase (C699T,
Anahi Guadalupe Figueroa-Torres, Lisneth Osiris Matias-Aguilar, Erika Coria-Ramirez, Edmundo Bonilla-Gonzalez, Humberto Gonzalez-Marquez, Isabel Ibarra-Gonzalez, Jose Rubicel Hernandez-Lopez, Jesus Hernandez-Juarez, Victor Manuel Dominguez-Reyes, Irma Isordia-Salas, Abraham Majluf-Cruz   +10 more
doaj   +1 more source

Hematinic deficiencies, hyperhomocysteinemia, and gastric parietal cell antibody positivity in atrophic glossitis patients with normocytosis

Journal of the Formosan Medical Association, 2020
Background/Purpose: Normocytosis is defined as having the mean corpuscular volume (MCV) between 80 fL and 99.9 fL. This study evaluated whether 944 atrophic glossitis (AG) patients with normocytosis had significantly higher frequencies of anemia ...
Chun-Pin Chiang, Yu-Hsueh Wu, Julia Yu-Fong Chang, Yi-Ping Wang, Yang-Che Wu, Andy Sun   +5 more
doaj   +1 more source

Familial hyperhomocysteinemia, age and peripheral vascular diseases - an Italian study

Veins and Lymphatics, 2013
Hyperhomocysteinemia is a widely recognized, although not yet entirely understood, risk factor for cardiovascular disease. Particularly, the complex relationships between age, hyperhomocysteinemia, predisposing genetic factors and peripheral vascular ...
Sandro Michelini, Marco Cardone, Adriano Micci, Francesco Cappellino, Alessandro Fiorentino, Vincenzo Sainato, Maira Moira, Rachele Todisco, Maddalena Todini, Serena Michelini, Guido Valle   +10 more
doaj   +1 more source

Serum B12, homocysteine levels, and their effect on peripheral neuropathy in Parkinson's disease: Indian cohort

Annals of Indian Academy of Neurology, 2020
Background: Cobalamin deficiency, either due to dietary inadequacy or increased consumption attributable to levodopa-mediated metabolic disturbance, and resultant hyperhomocysteinemia may contribute to peripheral neuropathy (PN) in Parkinson's disease ...
Neeharika L Mathukumalli, Mridula R Kandadai, Jabeen A Shaik, Meena A Kanikannan, Rupam Borgohain   +4 more
doaj   +1 more source

Changes in the physical structure and chain dynamics of elastin network in homocysteine-cultured arteries [PDF]

, 2009
The thermal and dielectric properties of the elastin network were investigated in arteries cultured with physiological and pathological concentrations of homocysteine, an aminoacid responsible of histological impairments in human arteries.
Chareyre, Corinne, Charpiot, Philippe, Dandurand, Jany, Foucault-Bertaud, Alexandrine, Lacabanne, Colette, Lamy, Edouard, Samouillan, Valérie   +6 more
core   +2 more sources

Elevated Levels of Methylmalonate and Homocysteine in Parkinson's Disease, Progressive Supranuclear Palsy and Amyotrophic Lateral Sclerosis [PDF]

, 2010
Background/Aims: Increasing evidence suggests that elevated levels of homocysteine (Hcy) and methylmalonate (MMA) may be involved in the pathogenesis of neurodegenerative diseases. Methods: The urine levels of MMA and serum levels of Hcy as well as folic
Bötzel, Kai, Giese, Armin, Levin, Johannes, Lorenzl, Stefan, Vogeser, Michael   +4 more
core   +1 more source

Hyperhomocysteinemia: Clinical Insights [PDF]

Journal of Central Nervous System Disease, 2020
Homocysteine (Hcy) is a sulfhydryl-containing amino acid, and intermediate metabolite formed in metabolising methionine (Met) to cysteine (Cys); defective Met metabolism can increase Hcy. The effect of hyperhomocysteinemia (HHcy) on human health, is well described and associated with multiple clinical conditions. HHcy is considered to be an independent
openaire   +3 more sources

Hyperhomocysteinemia leads to exacerbation of ischemic brain damage: Role of GluN2A NMDA receptors

Neurobiology of Disease, 2019
Hyperhomocysteinemia has been implicated in several neurodegenerative disorders including ischemic stroke. However, the pathological consequences of ischemic insult in individuals predisposed to hyperhomocysteinemia and the associated etiology are ...
Ankur Jindal, Sathyanarayanan Rajagopal, Lucas Winter, Joshua W. Miller, Donald W. Jacobsen, Jonathan Brigman, Andrea M. Allan, Surojit Paul, Ranjana Poddar   +8 more
doaj   +1 more source

Elevated homocysteine activates unfolded protein responses and causes aberrant trophoblast differentiation and mouse blastocyst development

Physiological Reports, 2022
Hyperhomocysteinemia may arise from folate/vitamin B12 deficiency, genetic polymorphisms, kidney disease, or hypothyroidism. It is associated with an increased risk of early pregnancy loss and placenta‐related complications of pregnancy, including pre ...
Nadejda Capatina, Graham J. Burton, Hong Wa Yung   +2 more
doaj   +1 more source

The Treatment of Hyperhomocysteinemia [PDF]

Annual Review of Medicine, 2009
The unique biochemical profile of homocysteine is characterized by chemical reactivity supporting a wide range of molecular effects and by a tendency to promote oxidant stress–induced cellular toxicity. Numerous epidemiological reports have established hyperhomocysteinemia as an independent risk factor for cardiovascular disease, cerebrovascular ...
Bradley A, Maron, Joseph, Loscalzo
openaire   +2 more sources