Homocysteine treatment alters redox capacity of both endothelial and tumor cells [PDF]
Homocysteine is a non-proteinogenic amino acid playing key roles in two interconnected metabolic pathways, namely, the activated methyl cycle and the linear trans-sulfuration pathway that allows the conversion of methionine to cysteine.
Cárdenas, Casimiro+5 more
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On the Origin of Western Diet Pathologies [PDF]
The ratio of the two sulfur-containing amino acids, methionine (Met) and cysteine (Cys), may be a determining factor for which foods contribute to longevity and health. It is shown here that substantially more Met than Cys is consistently found in foods,
John Schloss
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Association of increased levels of homocysteine and peripheral arterial disease in a Japanese-Brazilian population [PDF]
Objectives. Our aim was to evaluate the possible association between homocysteine levels and peripheral arterial disease (PAD) in a population-based study of Japanese-Brazilians.Materials and methods.
Barros, Newton+5 more
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Cystathionine beta synthase deficiency induces catalase-mediated hydrogen peroxide detoxification in mice liver [PDF]
International ...
Andreau, Karine+6 more
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Elevated Levels of Methylmalonate and Homocysteine in Parkinson's Disease, Progressive Supranuclear Palsy and Amyotrophic Lateral Sclerosis [PDF]
Background/Aims: Increasing evidence suggests that elevated levels of homocysteine (Hcy) and methylmalonate (MMA) may be involved in the pathogenesis of neurodegenerative diseases. Methods: The urine levels of MMA and serum levels of Hcy as well as folic
Bötzel, Kai+4 more
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Homocysteine, vitamin B12 and folate levels in premature coronary artery disease [PDF]
BACKGROUND: Hyperhomocysteinemia is known as an independent risk factor of atherosclerosis, but the probable role of hyperhomocysteinemia in premature Coronary Artery Disease (CAD) is not well studied.
A de Bree+43 more
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Homocysteine and nitric oxide in patients undergoing diagnostic coronary angiography. [PDF]
We evaluated the plasma homocysteine (tHcy) and nitric oxide metabolites (nitrite plus nitrate; NOx) data of consecutive patients undergoing diagnostic coronary angiography (n=79) with respect to the presence and severity of coronary artery disease (CAD),
Andican, Gulnur+7 more
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Increased telomere attrition following renal transplantation: impact of anti-metabolite therapy [PDF]
Background: The uremic milieu exposes chronic kidney disease (CKD) patients to premature ageing processes. The impact of renal replacement therapy (dialysis and renal transplantation [RTx]) or immunosuppressive treatment regimens on ageing biomarkers has
Bárány, Peter+13 more
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Hyperhomocysteinemia in Renal Transplantation: Preliminary Results [PDF]
Cardiovascular disease (CVD) is a major cause of morbidity and mortality after renal transplantation (RT).[1] and [2] The excess risk of CVD in RT is due in part to a higher prevalence of established atherosclerotic risk factors, including hypertension ...
Fonseca, Isabel+8 more
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Mutation (677C to T) in the methylenetetrahydrofolate reductase gene aggravates hyperhomocysteinemia in hemodialysis patients [PDF]
Mutation 677C to T in the methylenetetrahydrofolate reductase gene aggravates hyperhomocysteinemia in hemodialysis patients. Hyperhomocysteinemia is frequent in hemodialysis patients and represents an independent risk factor for vascular disease in these
Födinger, Manuela+7 more
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